MAN1C1 mannosidase, alpha, class 1C, member 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: MAN1C1provided by HGNC
Official Full Name: mannosidase, alpha, class 1C, member 1provided by HGNC
Primary source: HGNC:19080
See related: HPRD:14354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HMIC; MAN1C; MAN1A3; pp6318

Genomic context

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Location :: 1p35

Sequence :: Chromosome: 1; NC_000001.10 (25943959..26111258)

See MAN1C1 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
overexpression of Golgi alpha1,2-mannosidase IA, IB, and IC also accelerates ERAD of terminally misfolded human alpha1-antitrypsin variant null (Hong Kong) (NHK), and mannose trimming from the N-glycans on NHK in 293 cells
Title: Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Env, gp160, envelope glycoprotein	env	Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus	PubMed
Envelope surface glycoprotein gp120	env	Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL	PubMed
	env	HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex	PubMed
Envelope transmembrane glycoprotein gp41	env	Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q9NR34	O15198	SMAD9		HPRD	PubMed
BioGRID:121395	BioGRID:110268	SMAD9		BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley P et al, 2009). An early study in 1999 r...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
N-Glycan biosynthesis, organism-specific biosystem (from KEGG)
N-Glycan biosynthesis, organism-specific biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
N-Glycan biosynthesis, conserved biosystem (from KEGG)
N-Glycan biosynthesis, conserved biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
N-glycan precursor trimming, organism-specific biosystem (from KEGG)
N-glycan precursor trimming, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
N-glycan precursor trimming, conserved biosystem (from KEGG)
N-glycan precursor trimming, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
N-glycan trimming and elongation in the cis-Golgi, organism-specific biosystem (from REACTOME)
N-glycan trimming and elongation in the cis-Golgi, organism-specific biosystemAfter the transport of the glycoprotein to the cis-Golgi, the pathway of N-glycosylation bifurcates. Some N-glycans can be moved to subsequent steps of the secretory pathway without further modificat...
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, organism-specific biosystem (from REACTOME)
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, organism-specific biosystemIn the cis-Golgi, Man7, Man8 or Man9 N-glycans are progressively trimmed to Man5 N-glycans. The reaction can be catalyzed by one of three known mannosidases, expressed in different tissues and with s...
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; MartÃnez-MenÃ¡rguez et al, 1999...

General gene information

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Markers

SHGC-74415 (e-PCR)
- UniSTS:37125

WI-14148 (e-PCR)
- UniSTS:44295

MAN1C1 (e-PCR)
- UniSTS:503305

D8S2279 (e-PCR)
- UniSTS:473907

RH36069 (e-PCR)
- UniSTS:11072

A005U19 (e-PCR)
- UniSTS:13901

SHGC-105318 (e-PCR)
- UniSTS:169297

D15S1477 (e-PCR)
- UniSTS:474482

G35510 (e-PCR)
- UniSTS:44150

D1S1427 (e-PCR)
- UniSTS:149623

D1S1468 (e-PCR)
- UniSTS:149664

SHGC-37693 (e-PCR)
- UniSTS:60330

RH36124 (e-PCR)
- UniSTS:45292

Homology

Homologs of the MAN1C1 gene: The MAN1C1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium ion binding	TAS Traceable Author Statement more info	PubMed
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cellular protein metabolic process	TAS Traceable Author Statement more info
post-translational protein modification	TAS Traceable Author Statement more info
protein N-linked glycosylation	TAS Traceable Author Statement more info	PubMed
protein N-linked glycosylation via asparagine	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi membrane	TAS Traceable Author Statement more info
integral to Golgi membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Names: mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; 1,2-alpha-mannosidase IC; processing alpha-1,2-mannosidase IC

NP_065112.1

EC 3.2.1.113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020379.2 → NP_065112.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Status: VALIDATED

Source sequence(s)

AF261655, AL031280, DA068812

Consensus CDS

CCDS265.1

UniProtKB/Swiss-Prot

Q9NR34

Conserved Domains (1) summary

pfam01532
Location:181 – 617
Blast Score: 1414

Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p10 Primary Assembly

Range

25943959..26111258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

24197844..24350677

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018912.1 Alternate CHM1_1.0

Range

26158322..26325608

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01017762.1	None
genomic	ABBA01017763.1	None
genomic	ABBA01017764.1	None
genomic	ABBA01017765.1	None
genomic	ABBA01017766.1 (4402..9980)	None
genomic	ABBA01034885.1 (5586..12250)	None
genomic	AL020996.6 (55043..100200)	None
genomic	AL031280.7	None
genomic	AMYH01000393.1	None
genomic	AMYH01000394.1	None
genomic	CH471059.2	EAX07870.1
		EAX07871.1
mRNA	AB209275.1	BAD92512.1
mRNA	AF261655.1	AAF97058.1
mRNA	AK128560.1	None
mRNA	BC038959.1	None
mRNA	BC137017.1	AAI37018.1
mRNA	DA068812.1	None