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LYRM4 LYR motif containing 4 [ Homo sapiens (human) ]

Gene ID: 57128, updated on 11-Sep-2014
Official Symbol
LYRM4provided by HGNC
Official Full Name
LYR motif containing 4provided by HGNC
Primary source
HGNC:HGNC:21365
Locus tag
RP11-428J1.4
See related
Ensembl:ENSG00000214113; HPRD:12855; MIM:613311; Vega:OTTHUMG00000014173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ISD11; CGI-203; COXPD19; C6orf149
See LYRM4 in Epigenomics, MapViewer
Location:
6p25.1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (5031753..5260950, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (5047395..5261172, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100129461 Neighboring gene ribosomal protein S18 pseudogene 8 Neighboring gene ribonuclease P/MRP 40kDa subunit Neighboring gene transcription factor B2, mitochondrial pseudogene Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene microRNA 3691 Neighboring gene putative uncharacterized protein C3orf66-like Neighboring gene phenylalanyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC101927972 Neighboring gene uncharacterized LOC102724161 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 37

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19
MedGen: CN183092 OMIM: 615595 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
NHGRI GWA Catalog
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Mitochondrial iron-sulfur cluster biogenesis, organism-specific biosystem (from REACTOME)
    Mitochondrial iron-sulfur cluster biogenesis, organism-specific biosystemIron-sulfur (Fe-S) proteins are localized in the cytosol, nucleus, and mitochondria of mammalian cells (reviewed in Stemmler et al. 2010, Rouault 2012, Bandyopadhyay et al. 2008, Lill 2009, Lill et a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
LYR motif-containing protein 4
Names
LYR motif-containing protein 4
homolog of yeast Isd11
mitochondrial matrix Nfs1 interacting protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164840.2NP_001158312.1  LYR motif-containing protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    CK819966, HY168919
    UniProtKB/TrEMBL
    F5H189
    Related
    ENSP00000443900, ENST00000500576
    Conserved Domains (2) summary
    pfam13232
    Location:767
    Blast Score: 210
    Complex1_LYR_1; Complex1_LYR-like
    pfam13900
    Location:75122
    Blast Score: 262
    GVQW; Putative binding domain
  2. NM_001164841.2NP_001158313.1  LYR motif-containing protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AF170070, AL035653, BC067762, BX353584, CA310019, HY168919
    Consensus CDS
    CCDS54961.1
    UniProtKB/TrEMBL
    C9JRX8
    UniProtKB/Swiss-Prot
    Q9HD34
    Related
    ENSP00000420026, OTTHUMP00000214159, ENST00000464010, OTTHUMT00000353484
    Conserved Domains (1) summary
    pfam13232
    Location:767
    Blast Score: 195
    Complex1_LYR_1; Complex1_LYR-like
  3. NM_020408.5NP_065141.3  LYR motif-containing protein 4 isoform 1

    See proteins identical to NP_065141.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF170070, AL035653, BC067762, CA310019, HY168919
    Consensus CDS
    CCDS4493.1
    UniProtKB/Swiss-Prot
    Q9HD34
    Conserved Domains (1) summary
    pfam13232
    Location:767
    Blast Score: 188
    Complex1_LYR_1; Complex1_LYR-like

RNA

  1. NR_104417.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF170070, AK309458, AL035653, BC067762, CA310019, HY168919
  2. NR_104418.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria
    Source sequence(s)
    AF170070, AL035653, BC067762, CA310019, HY168919

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    5031753..5260950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715151.1XP_006715214.1  

    Conserved Domains (1) summary
    pfam13232
    Location:767
    Blast Score: 205
    Complex1_LYR_1; Complex1_LYR-like
  2. XM_005249237.2XP_005249294.1  

    Conserved Domains (1) summary
    pfam13232
    Location:767
    Blast Score: 199
    Complex1_LYR_1; Complex1_LYR-like
  3. XM_005249239.1XP_005249296.1  

    UniProtKB/TrEMBL
    C9JY28
    Related
    ENSP00000419928, OTTHUMP00000214158, ENST00000480566, OTTHUMT00000353483
    Conserved Domains (1) summary
    pfam13232
    Location:767
    Blast Score: 178
    Complex1_LYR_1; Complex1_LYR-like

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    4983042..5135598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    5110792..5263825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)