REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) [Homo sapiens] - Gene

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Summary

Official Symbol: REXO4provided by HGNC
Official Full Name: REX4, RNA exonuclease 4 homolog (S. cerevisiae)provided by HGNC
Primary source: HGNC:12820
Locus tag: RP11-244N20.5
See related: Ensembl:ENSG00000148300; HPRD:04239; MIM:602930; Vega:OTTHUMG00000020870
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: REX4; XPMC2; XPMC2H

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Genomic context

Location :: 9q34.2

Sequence :: Chromosome: 9; NC_000009.11 (136271186..136283164, complement)

See REXO4 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

determined that the catalytic activity of hPMC2 is required for repair of abasic sites that result from estrogen-induced DNA damage
Title: The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.
Observational study of gene-disease association. (HuGE Navigator)
Title: Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9GZR2	P03372	ESR1	HPRD	PubMed
Q9GZR2	Q92731	ESR2	HPRD	PubMed
BioGRID:121375	BioGRID:108403	ESR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:121375	BioGRID:108404	ESR2	BioGRID	PubMed	Reconstituted Complex
BioGRID:121375	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
exonuclease activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: RNA exonuclease 4

Names: RNA exonuclease 4; hPMC2; exonuclease XPMC2; XPMC2 prevents mitotic catastrophe 2 homolog; Xenopus prevents mitotic catatrophe 2 homolog; Xenopus prevents mitotic catastrophe 2 homolog; prevents mitotic catastrophe 2 protein homolog

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020385.2 → NP_065118.2 RNA exonuclease 4

Status: VALIDATED

Source sequence(s)

AF273304, AL136894

Consensus CDS

CCDS6969.1

UniProtKB/Swiss-Prot

Q9GZR2

Related

ENSP00000361010, OTTHUMP00000022484, ENST00000371942, OTTHUMT00000054899

Conserved Domains (1) summary

cd06144
Location:244 – 394
Blast Score: 742

REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

136271186..136283164, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 PATCHES

Genomic

NW_003315925.1 Reference GRCh37.p5 PATCHES

Range

232156..244138, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

105773013..105784995, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL158826.23	CAI12845.1
		CAI12847.1
		CAI12848.1
		CAI12849.1
genomic	AL593848.15 (57576..69558)	None
genomic	CH471090.1	EAW88082.1
mRNA	AF273304.1	AAF98162.1
mRNA	AF295774.1	AAG02123.1
mRNA	AK000247.1	None
mRNA	AK025493.1	BAB15152.1
mRNA	AK295982.1	BAG58757.1
mRNA	AK304547.1	BAG65343.1
mRNA	AK310164.1	None
mRNA	AK314333.1	BAG36979.1
mRNA	AK315904.1	BAH14275.1
mRNA	AL136894.1	CAB66828.1
mRNA	BC009274.2	AAH09274.1
mRNA	BC071691.1	None
other-genetic	AM392617.1	CAL37495.1
other-genetic	DQ891911.2	ABM82837.1
other-genetic	DQ895096.2	ABM86022.1