My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    PCNP PEST proteolytic signal containing nuclear protein [ Homo sapiens ]

    Gene ID: 57092, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    PCNPprovided by HGNC
    Official Full Name
    PEST proteolytic signal containing nuclear proteinprovided by HGNC
    Primary source
    HGNC:30023
    See related
    Ensembl:ENSG00000081154; HPRD:17826; Vega:OTTHUMG00000159108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKFZp781I24156
    Help top of page

    Genomic context

    Location :
    3q12.3
    Sequence :
    Chromosome: 3; NC_000003.11 (101293042..101313281)
    See PCNP in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 172, member B pseudogene Neighboring gene RNA (guanine-9-) methyltransferase domain containing 1 Neighboring gene ribosomal protein S18 pseudogene 5 Neighboring gene ribosomal protein L32 pseudogene 7 Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene uncharacterized LOC100009676

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. Mori T, et al. FEBS Lett, 2004 Jan 16. PMID 14741369.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Mori T, et al. Biochem Biophys Res Commun, 2002 Aug 23. PMID 12176013.

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NIRF has ubiquitination activity, the hallmark of a ubiquitin ligase. PCNP was readily ubiquitinated in 293 and COS-7 cells, and NIRF ubiquitinated PCNP in vitro as well as in vivo.
      Title: NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8WW12 Q96PU4 UHRF2    HPRD  PubMed  
    BioGRID:121360 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121360 BioGRID:125434 UHRF2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    PEST proteolytic signal-containing nuclear protein
    Names
    PEST proteolytic signal-containing nuclear protein
    PEST-containing nuclear protein
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020357.1 → NP_065090.1  PEST proteolytic signal-containing nuclear protein

      Status: PROVISIONAL

      Source sequence(s)
      AB037675
      Consensus CDS
      CCDS2942.1
      UniProtKB/Swiss-Prot
      Q8WW12
      Related
      ENSP00000265260, OTTHUMP00000214092, ENST00000265260, OTTHUMT00000353338

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      101293042..101313281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      98661973..98682208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073861.29 (115362..135601) None
    genomic CH471052.2 EAW79790.1
      EAW79791.1
      EAW79792.1
      EAW79793.1
      EAW79794.1
    mRNA AB037675.1 BAB03501.1
    mRNA AK025551.1 None
    mRNA AK098760.1 None
    mRNA AK222978.1 BAD96698.1
    mRNA AK314629.1 BAG37194.1
    mRNA AL110143.1 None
    mRNA BC013916.1 AAH13916.1
    mRNA BC022001.2 AAH22001.1
    mRNA BC107796.1 None
    mRNA BX647886.1 None
    mRNA CR627371.1 CAH10470.1
    other-genetic DQ890799.2 ABM81725.1
    other-genetic DQ893953.2 ABM84879.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53GF3 GenPept UniProtKB/TrEMBL:Q53GF3
    Q8WW12.2 GenPept UniProtKB/Swiss-Prot:Q8WW12
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...