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    SLC17A6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 [ Homo sapiens ]

    Gene ID: 57084, updated on 19-May-2012
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    Summary

    Official Symbol
    SLC17A6provided by HGNC
    Official Full Name
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6provided by HGNC
    Primary source
    HGNC:16703
    See related
    Ensembl:ENSG00000091664; HPRD:10459; MIM:607563; Vega:OTTHUMG00000166063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNPI; VGLUT2
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    Genomic context

    Location :
    11p14.3
    Sequence :
    Chromosome: 11; NC_000011.9 (22359667..22401049)
    See SLC17A6 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene NEL-like 1 (chicken) Neighboring gene isocitrate dehydrogenase 3 (NAD+) gamma pseudogene Neighboring gene anoctamin 5 Neighboring gene Fanconi anemia, complementation group F Neighboring gene growth arrest-specific 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia. Shen YC, et al. Schizophr Res, 2010 Aug. PMID 20541370.
    2. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. Lisitskaia KV, et al. Mol Gen Mikrobiol Virusol, 2010. PMID 20540360.
    3. Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia. Uezato A, et al. Bipolar Disord, 2009 Nov. PMID 19839996.
    4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Need AC, et al. Eur J Hum Genet, 2009 Jul. PMID 19156168.
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Gratacòs M, et al. Am J Med Genet B Neuropsychiatr Genet, 2009 Sep 5. PMID 19086053.

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study may lend support to the multiple rare mutations hypothesis of schizophrenia, and may provide genetic clues to indicate the involvement of the glutamate transmission pathway in the pathogenesis of schizophrenia.
      Title: Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia.
    2. This study decreased VGLUT2 mRNA expression in major depressive disorder in the middle temporal gyrus, and increased VGLUT2 mRNA expression in schizophrenia in the inferior temporal gyrus.
      Title: Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia.
    3. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
    4. Our results suggest that VGLUT1 expression in the prefrontal cortex could be used as a valuable neurochemical marker of dementia in AD.
      Title: Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia.
    6. VGluT2 is the only vesicular glutamate transporter expressed in transgenic ventral tegmental area/substantia nigra dopamine neurons in vivo.
      Title: Developmental and target-dependent regulation of vesicular glutamate transporter expression by dopamine neurons.
    7. higher in tendinosis tendons compared to normal tendons
      Title: VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes.
    8. Vesicular glutamate transporter 2 was unchanged at both levels of gene expression.
      Title: Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia.
    9. Docking and homology modeling explain the inhibition of VGLUT2.
      Title: Docking and homology modeling explain inhibition of the human vesicular glutamate transporters.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Nicotine addiction, organism-specific biosystem (from KEGG)
      Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Nicotine addiction, conserved biosystem (from KEGG)
      Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Organic anion transporters, organism-specific biosystem (from REACTOME)
      Organic anion transporters, organism-specific biosystemThe SLC17 gene family encode proteins which are organic anion transporters. There are three distinct subfamilies within SLC17; vesicular glutamate transporters (VGLUT1-3 encoded by SLC17A7,6 and 8), ...
    • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
      Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
      Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
      Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-glutamate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ion transport TAS
    Traceable Author Statement
    more info
    		  
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    synaptosome IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    vesicular glutamate transporter 2
    Names
    vesicular glutamate transporter 2
    differentiation-associated BNPI
    solute carrier family 17 member 6
    differentiation-associated Na-dependent inorganic phosphate cotransporter
    differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020346.2 → NP_065079.1  vesicular glutamate transporter 2

      Status: VALIDATED

      Source sequence(s)
      AB032435, BQ185289, BQ188116, CK823303, DA392769
      Consensus CDS
      CCDS7856.1
      UniProtKB/Swiss-Prot
      Q9P2U8
      Related
      ENSP00000263160, OTTHUMP00000231813, ENST00000263160, OTTHUMT00000387671
      Conserved Domains (2) summary
      cd06174
      Location:75 – 498
      Blast Score: 396
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:70 – 511
      Blast Score: 771
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      22359667..22401049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      22042899..22084263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC040936.9 (26301..67677) None
    genomic CH471064.2 EAW68324.1
    mRNA AB032435.1 BAA92874.1
    mRNA AK294502.1 BAG57719.1
    mRNA AK309131.1 None
    mRNA BC069629.1 AAH69629.1
    mRNA BC069640.1 AAH69640.1
    mRNA BC069646.1 AAH69646.1
    mRNA BQ185289.1 None
    mRNA BQ188116.1 None
    mRNA CK823303.1 None
    mRNA DA392769.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P2U8.1 GenPept UniProtKB/Swiss-Prot:Q9P2U8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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