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    DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 [ Homo sapiens ]

    Gene ID: 57062, updated on 11-May-2012

    Summary

    Official Symbol
    DDX24provided by HGNC
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24provided by HGNC
    Primary source
    HGNC:13266
    See related
    Ensembl:ENSG00000089737; HPRD:05860; MIM:606181; Vega:OTTHUMG00000171301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    14q32
    Sequence :
    Chromosome: 14; NC_000014.8 (94517268..94547558, complement)
    See DDX24 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 521 Neighboring gene OTU domain, ubiquitin aldehyde binding 2 Neighboring gene interferon, alpha-inducible protein 27-like 1 Neighboring gene interferon, alpha-inducible protein 27

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9GZR7 Q9Y276 BCS1L    HPRD  PubMed  
    Q9GZR7 Q96E40 C9orf9    HPRD  PubMed  
    Q9GZR7 Q9GZR7 DDX24    HPRD  PubMed  
    Q9GZR7 P60228 EIF3E    HPRD  PubMed  
    Q9GZR7 Q09472 EP300    HPRD  PubMed  
    Q9GZR7 Q13158 FADD    HPRD  PubMed  
    Q9GZR7 Q9Y2X7 GIT1    HPRD  PubMed  
    Q9GZR7 P08238 HSP90AB1    HPRD  PubMed  
    Q9GZR7 P11021 HSPA5    HPRD  PubMed  
    Q9GZR7 P14902 IDO1    HPRD  PubMed  
    Q9GZR7 Q13352 ITGB3BP    HPRD  PubMed  
    Q9GZR7 Q9NXB0 MKS1    HPRD  PubMed  
    Q9GZR7 Q9BYD3 MRPL4    HPRD  PubMed  
    Q9GZR7 Q9P2S2 NRXN2    HPRD  PubMed  
    Q9GZR7 Q15102 PAFAH1B3    HPRD  PubMed  
    Q9GZR7 Q13526 PIN1    HPRD  PubMed  
    Q9GZR7 Q14181 POLA2    HPRD  PubMed  
    Q9GZR7 P14222 PRF1    HPRD  PubMed  
    Q9GZR7 Q9H3S7 PTPN23    HPRD  PubMed  
    Q9GZR7 P78406 RAE1    HPRD  PubMed  
    Q9GZR7 Q13813 SPTAN1    HPRD  PubMed  
    Q9GZR7 Q9NQ34 TMEM9B    HPRD  PubMed  
    Q9GZR7 P60174 TPI1    HPRD  PubMed  
    Q9GZR7 O14717 TRDMT1    HPRD  PubMed  
    Q9GZR7 Q9Y277 VDAC3    HPRD  PubMed  
    BioGRID:121353 BioGRID:107087 BCS1L    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:109857 EIF3E    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:199419 Eif4a2    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:115237 G3BP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:118789 GIT1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:109558 HSP90AB1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:109541 HSPA5    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:116992 ITGB3BP    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:120249 MKS1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:111317 PIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:117176 POLA2    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:112587 SPTAN1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:121353 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:113020 TPI1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:108124 TRDMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:115939 USP39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121353 BioGRID:113262 VDAC3    BioGRID  PubMed Two-hybrid 
    BioGRID:121353 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    • Homologs of the DDX24 gene: The DDX24 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent RNA helicase activity NAS
    Non-traceable Author Statement
    more info
     
    ATP-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA helicase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    ATP-dependent RNA helicase DDX24
    DEAD box protein 24
    S. cerevisiae CHL1-like helicase
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24
    NP_065147.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020414.3NP_065147.1  ATP-dependent RNA helicase DDX24

      Status: REVIEWED

      Source sequence(s)
      AF214731
      Consensus CDS
      CCDS9918.1
      UniProtKB/Swiss-Prot
      Q9GZR7
      Related
      ENSP00000328690, OTTHUMP00000245764, ENST00000330836, OTTHUMT00000412861
      Conserved Domains (2) summary
      cd00079
      Location:572690
      Blast Score: 255
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl09099
      Location:384511
      Blast Score: 327
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      94517268..94547558, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      74697258..74727325, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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