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slc8a2a solute carrier family 8 member 2a [ Danio rerio (zebrafish) ]

Gene ID: 569480, updated on 27-Mar-2024

Summary

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Official Symbol
slc8a2aprovided by ZNC
Official Full Name
solute carrier family 8 member 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-155
See related
Ensembl:ENSDARG00000008912 AllianceGenome:ZFIN:ZDB-GENE-060531-155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-85k8.4
Summary
Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to act upstream of or within cell communication; metal ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in axon; postsynapse; and sarcolemma. Predicted to be integral component of plasma membrane. Is expressed in ovary. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (36854756..36893355)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (36254582..36293202)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438658 Neighboring gene P1, F-box associated domain containing Neighboring gene serine and arginine rich splicing factor 7a Neighboring gene heterogeneous nuclear ribonucleoprotein L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. Liao BK, et al. BMC Genomics, 2007 Oct 4. PMID 17915033, Free PMC Article
  2. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540
  3. On the tubulin polymerization promoting proteins of zebrafish. Orosz F. Biochem Biophys Res Commun, 2015 Feb 13. PMID 25576359
  4. Effects of dietary methylmercury on the zebrafish brain: histological, mitochondrial, and gene transcription analyses. Cambier S, et al. Biometals, 2012 Feb. PMID 21947502
  5. Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Shih YH, et al. Circ Cardiovasc Genet, 2015 Apr. PMID 25583992, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium:sodium antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium/calcium exchanger 2; sodium/calcium exchanger 2a
Names
ncx2a
solute carrier family 8 (sodium/calcium exchanger), member 2
solute carrier family 8 (sodium/calcium exchanger), member 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123296.1 → NP_001116768.1  sodium/calcium exchanger 2a precursor

    See identical proteins and their annotated locations for NP_001116768.1

    Status: PROVISIONAL

    Source sequence(s)
    EU559287
    UniProtKB/TrEMBL
    B2CZC3
    Related
    ENSDARP00000117843.2, ENSDART00000145182.3
    Conserved Domains (5) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:30 → 891
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:718 → 882
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    36854756..36893355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301672.3 → XP_009299947.1  sodium/calcium exchanger 2 isoform X1

    See identical proteins and their annotated locations for XP_009299947.1

    UniProtKB/TrEMBL
    A0A8M3ASJ4
    Conserved Domains (5) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:30 → 919
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:746 → 910
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  2. XM_009301675.3 → XP_009299950.1  sodium/calcium exchanger 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASN9
    Conserved Domains (5) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:30 → 897
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:724 → 888
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  3. XM_009301674.3 → XP_009299949.1  sodium/calcium exchanger 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B9T8
    Conserved Domains (5) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:30 → 913
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:740 → 904
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  4. XM_009301676.3 → XP_009299951.1  sodium/calcium exchanger 2 isoform X4

    UniProtKB/TrEMBL
    A0A286Y8H6, A0A8M3B2Q3
    Conserved Domains (5) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:30 → 891
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:718 → 882
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  5. XM_009301679.3 → XP_009299954.1  sodium/calcium exchanger 2 isoform X7

    UniProtKB/TrEMBL
    A0A8M3B9U2
    Conserved Domains (4) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    pfam01699
    Location:70 → 241
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  6. XM_009301678.3 → XP_009299953.1  sodium/calcium exchanger 2 isoform X6

    UniProtKB/TrEMBL
    A0A8M3ASJ9
    Conserved Domains (4) summary
    smart00237
    Location:506 → 595
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    pfam01699
    Location:70 → 241
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:385 → 474
    Calx-beta; Calx-beta domain
    pfam16494
    Location:244 → 365
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

  7. XM_009301677.2 → XP_009299952.1  sodium/calcium exchanger 2 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AZU6
    Conserved Domains (5) summary
    smart00237
    Location:444 → 533
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:2 → 857
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:684 → 848
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:323 → 412
    Calx-beta; Calx-beta domain
    pfam16494
    Location:182 → 303
    Na_Ca_ex_C; C-terminal extension of sodium/calcium exchanger domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394595.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    111752..134367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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