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DUSP22 dual specificity phosphatase 22 [ Homo sapiens (human) ]

Gene ID: 56940, updated on 8-May-2016
Official Symbol
DUSP22provided by HGNC
Official Full Name
dual specificity phosphatase 22provided by HGNC
Primary source
HGNC:HGNC:16077
See related
Ensembl:ENSG00000112679 HPRD:13255; MIM:616778; Vega:OTTHUMG00000014113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
Orthologs
Location:
6p25.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (292057..351355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (292101..351355)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374869 Neighboring gene uncharacterized LOC285766 Neighboring gene uncharacterized LOC105374870 Neighboring gene uncharacterized LOC102723922 Neighboring gene uncharacterized LOC105374871 Neighboring gene uncharacterized LOC105374872 Neighboring gene uncharacterized LOC105375104

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ35864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
inactivation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dual specificity protein phosphatase 22
Names
JNK-stimulating phosphatase 1
JNK-stimulatory phosphatase-1
MAP kinase phosphatase x
homolog of mouse dual specificity phosphatase LMW-DSP2
low molecular weight dual specificity phosphatase 2
mitogen-activated protein kinase phosphatase x
NP_001273484.1
NP_064570.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286555.1NP_001273484.1  dual specificity protein phosphatase 22 isoform a

    See identical proteins and their annotated locations for NP_001273484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK296402, AL365272, AY249859, BX107497
    Consensus CDS
    CCDS69035.1
    UniProtKB/Swiss-Prot
    Q9NRW4
    Related
    ENSP00000397459, OTTHUMP00000015939, ENST00000419235, OTTHUMT00000039622
    Conserved Domains (1) summary
    cd00127
    Location:4139
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_020185.4NP_064570.1  dual specificity protein phosphatase 22 isoform b

    See identical proteins and their annotated locations for NP_064570.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the 3' coding region and 3' UTR and includes an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AF424702, AY249859, BX107497
    Consensus CDS
    CCDS4468.1
    UniProtKB/Swiss-Prot
    Q9NRW4
    Related
    ENSP00000345281, OTTHUMP00000015938, ENST00000344450, OTTHUMT00000039621
    Conserved Domains (1) summary
    cd00127
    Location:4139
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RNA

  1. NR_104473.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272, AY249859, BX107497, DA950312
  2. NR_104474.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272, AY249859, BX107497, DB177174
  3. NR_104475.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272, AY249859, BX107497, BX362191

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    292057..351355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514757.1XP_011513059.1  

    Conserved Domains (1) summary
    cd00127
    Location:579
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    290469..349836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)