These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_030359.1 RefSeqGene
- Range
- 5001..97960
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001248002.1 → NP_001234931.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
- Source sequence(s)
-
AC068794, AC092829, AF246961, AF256215, BQ774827, CV388040
- UniProtKB/Swiss-Prot
-
Q8WYA1
- Conserved Domains (4) summary
-
- cd00083
Location:95 – 147
Blast Score: 150
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:356 – 454
Blast Score: 174
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam00989
Location:167 – 273
Blast Score: 115
- PAS; PAS fold
- pfam08447
Location:367 – 451
Blast Score: 129
- PAS_3; PAS fold
-
NM_001248003.1 → NP_001234932.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate in-frame donor splice site, and lacks two consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (3) compared to isoform 1.
- Source sequence(s)
-
AC068794, AC092829, AF246962, AF256215, BQ774827, CV388040
- UniProtKB/Swiss-Prot
-
Q8WYA1
- Conserved Domains (4) summary
-
- cd00083
Location:72 – 124
Blast Score: 146
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:333 – 431
Blast Score: 174
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam00989
Location:144 – 250
Blast Score: 115
- PAS; PAS fold
- pfam08447
Location:344 – 428
Blast Score: 128
- PAS_3; PAS fold
-
NM_001248004.1 → NP_001234933.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 4
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks two consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (4) missing an internal protein segment compared to isoform 1.
- Source sequence(s)
-
AC068794, AC092829, AF246963, AF256215, BQ774827, CV388040
- UniProtKB/Swiss-Prot
-
Q8WYA1
- Conserved Domains (4) summary
-
- cd00083
Location:61 – 113
Blast Score: 147
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:322 – 420
Blast Score: 174
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam00989
Location:133 – 239
Blast Score: 115
- PAS; PAS fold
- pfam08447
Location:333 – 417
Blast Score: 128
- PAS_3; PAS fold
-
NM_001248005.1 → NP_001234934.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 5
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) uses an alternate in-frame donor splice site, lacks two consecutive in-frame coding exons, and another exon in the 3' region that causes a frame-shift, compared to variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
- Source sequence(s)
-
AC068794, AC092829, AF246960, AF256215, AK296706, BQ774827, CV388040
- UniProtKB/TrEMBL
-
B7Z429
- UniProtKB/TrEMBL
-
F5H402
- UniProtKB/Swiss-Prot
-
Q8WYA1
- Conserved Domains (4) summary
-
- cd00083
Location:72 – 124
Blast Score: 144
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:333 – 431
Blast Score: 173
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam00989
Location:144 – 250
Blast Score: 115
- PAS; PAS fold
- pfam08447
Location:344 – 428
Blast Score: 127
- PAS_3; PAS fold
-
NM_020183.4 → NP_064568.3 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AC068794, AC092829, AF246960, AF256215, BQ774827, CV388040
- Consensus CDS
-
CCDS8712.1
- UniProtKB/Swiss-Prot
-
Q8WYA1
- Related
- ENSP00000266503, OTTHUMP00000240589, ENST00000266503, OTTHUMT00000403162
- Conserved Domains (4) summary
-
- cd00083
Location:109 – 161
Blast Score: 150
- HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
- cd00130
Location:370 – 468
Blast Score: 174
- PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
- pfam00989
Location:181 – 287
Blast Score: 115
- PAS; PAS fold
- pfam08447
Location:381 – 465
Blast Score: 128
- PAS_3; PAS fold
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000012.11 Reference GRCh37.p5 Primary Assembly
- Range
- 27485988..27573466
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000144.1 Alternate HuRef
- Range
- 27255121..27342576
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)