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    NCLN nicalin [ Homo sapiens ]

    Gene ID: 56926, updated on 11-May-2012
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    Summary

    Official Symbol
    NCLNprovided by HGNC
    Official Full Name
    nicalinprovided by HGNC
    Primary source
    HGNC:26923
    See related
    Ensembl:ENSG00000125912; HPRD:07126; MIM:609156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET59
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    Genomic context

    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (3185875..3209573)
    See NCLN in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha 15 (Gq class) Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene nuclear factor I/C (CCAAT-binding transcription factor)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q969V3 NODAL modulator 3 NOMO3    HPRD  PubMed  
    Q969V3 P69849 NOMO3    HPRD  PubMed  
    BioGRID:121253 BioGRID:116991 NOMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121253 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    nicalin
    Names
    nicalin
    nicastrin-like protein
    nicalin homolog (zebrefish)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020170.3 → NP_064555.2  nicalin precursor

      Status: VALIDATED

      Source sequence(s)
      AL136567, AL365369, BC003076, BC007275, BC008920, BC010064, BC013283, BC025926
      Consensus CDS
      CCDS32869.1
      UniProtKB/Swiss-Prot
      Q969V3
      Related
      ENSP00000246117, ENST00000246117
      Conserved Domains (1) summary
      cd03882
      Location:130 – 429
      Blast Score: 1137
      M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      3185875..3209573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      2952961..2976782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005331.2 AAC27667.1
    genomic AC011547.4 (17007..40705) None
    genomic CH471139.2 EAW69330.1
      EAW69331.1
      EAW69332.1
      EAW69333.1
      EAW69334.1
      EAW69335.1
    genomic FB794076.1 CAW38766.1
    genomic FB826795.1 CAW54087.1
    genomic HB664135.1 CBC04638.1
    genomic HB696854.1 CBC26779.1
    mRNA AK022309.1 None
    mRNA AK125002.1 None
    mRNA AK172848.1 BAD18812.1
    mRNA AK314044.1 BAG36753.1
    mRNA AL136567.1 CAB66502.1
    mRNA AL365369.1 CAB96945.1
    mRNA BC003076.2 AAH03076.2
    mRNA BC007275.1 AAH07275.1
    mRNA BC008920.2 AAH08920.2
    mRNA BC010064.2 AAH10064.2
    mRNA BC013283.2 AAH13283.2
    mRNA BC019091.2 AAH19091.2
    mRNA BC025926.1 AAH25926.1
    mRNA CR533566.1 CAG38597.1
    other-genetic AM393010.1 CAL37888.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969V3.2 GenPept UniProtKB/Swiss-Prot:Q969V3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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