C8orf4 chromosome 8 open reading frame 4 [Homo sapiens] - Gene

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Summary

Official Symbol: C8orf4provided by HGNC
Official Full Name: chromosome 8 open reading frame 4provided by HGNC
Primary source: HGNC:1357
See related: Ensembl:ENSG00000176907; HPRD:09650; MIM:607702; Vega:OTTHUMG00000164045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TC1; TC-1
Summary: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

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Genomic context

Location :: 8p11.2

Sequence :: Chromosome: 8; NC_000008.10 (40010989..40012821)

See C8orf4 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated G(1)- to S-phase transition of the cell cycle.
Title: TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition.
intrinsically disordered TC-1 interacts with Cby via its transient helical structure
Title: The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity.
TC-1 over expression is transforming and may link with the FGFR pathway in a subset of breast cancer.
Title: Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.
The TC1 coordinates the up-regulation of Wnt/beta-catenin target genes that are implicated in the aggressive biological behavior of cancers.
Title: TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.
Our data suggest that TC1 is a novel heat shock response regulator.
Title: TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response.
Gene induces transformed phenotype when overexpressed in a cancer breast cell line.
Title: Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.
Overexpression of TC-1 may be important in thyroid carcinogenesis.
Title: TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.
data indicate that TC1 is a novel upstream regulator of the Wnt/beta-catenin pathway that enhances aggressive behavior of cancers
Title: TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: uncharacterized protein C8orf4

Names: uncharacterized protein C8orf4; human thyroid cancer 1; thyroid cancer protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020130.4 → NP_064515.1 uncharacterized protein C8orf4

Status: REVIEWED

Source sequence(s)

AI861861, AI935347, BC021672, BX434108

Consensus CDS

CCDS6115.1

UniProtKB/Swiss-Prot

Q9NR00

Related

ENSP00000319914, OTTHUMP00000225689, ENST00000315792, OTTHUMT00000376943

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

40010989..40012821

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

38544324..38546155

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC022733.8 (54199..55653)	None
genomic	AF268038.1	None
genomic	CH471080.2	EAW63268.1
mRNA	AF268037.1	AAF78961.1
mRNA	AI861861.1	None
mRNA	AI935347.1	None
mRNA	AK026240.1	None
mRNA	BC020623.1	AAH20623.1
mRNA	BC021672.1	AAH21672.1
mRNA	BM976768.1	None
mRNA	BX434108.2	None
other-genetic	EU832636.1	ACE87727.1
other-genetic	EU832712.1	ACE87044.1
other-genetic	HQ448735.1	ADQ33213.1