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C8orf4 chromosome 8 open reading frame 4 [ Homo sapiens (human) ]

Gene ID: 56892, updated on 26-May-2016
Official Symbol
C8orf4provided by HGNC
Official Full Name
chromosome 8 open reading frame 4provided by HGNC
Primary source
HGNC:HGNC:1357
See related
Ensembl:ENSG00000176907 HPRD:09650; MIM:607702; Vega:OTTHUMG00000164045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TC1; TC-1
Summary
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]
Orthologs
Location:
8p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (40153468..40155308)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (40010987..40012827)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene uncharacterized LOC105379385 Neighboring gene uncharacterized LOC105379386 Neighboring gene uncharacterized LOC105379387 Neighboring gene uncharacterized LOC105379388

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genomic determinants of motor and cognitive outcomes in Parkinson's disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC22806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein C8orf4
Names
human thyroid cancer 1
thyroid cancer protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020130.4NP_064515.1  protein C8orf4

    See identical proteins and their annotated locations for NP_064515.1

    Status: REVIEWED

    Source sequence(s)
    AI861861, AI935347, BC021672, BX434108
    Consensus CDS
    CCDS6115.1
    UniProtKB/Swiss-Prot
    Q9NR00
    Related
    ENSP00000319914, OTTHUMP00000225689, ENST00000315792, OTTHUMT00000376943
    Conserved Domains (1) summary
    pfam15063
    Location:785
    TC1; Thyroid cancer protein 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    40153468..40155308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    40057852..40059691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)