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RAD18 RAD18 E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 56852, updated on 5-Jul-2015
Official Symbol
RAD18provided by HGNC
Official Full Name
RAD18 E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:18278
See related
Ensembl:ENSG00000070950; HPRD:09242; MIM:605256; Vega:OTTHUMG00000090545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF73
Summary
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Orthologs
See RAD18 in Epigenomics, MapViewer
Location:
3p25.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (8877196..8963475, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (8918880..9005159, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ssu-2 homolog (C. elegans) Neighboring gene caveolin 3 Neighboring gene oxytocin receptor Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene uncharacterized LOC101927416 Neighboring gene SRGAP3 antisense RNA 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 Integrase interacts with (co-immunoprecipitates) and co-localizes with hRad18 suggesting a role for hRad18 in the DNA repair events associated with the HIV-1 integration process PubMed

Go to the HIV-1, Human Interaction Database

  • DNA Damage Bypass, organism-specific biosystem (from REACTOME)
    DNA Damage Bypass, organism-specific biosystemIn addition to various processes for removing lesions from the DNA, cells have developed specific mechanisms for tolerating unrepaired damage during the replication of the genome. These mechanisms ar...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
  • Recognition of DNA damage by PCNA-containing replication complex, organism-specific biosystem (from REACTOME)
    Recognition of DNA damage by PCNA-containing replication complex, organism-specific biosystemDamaged double strand DNA (dsDNA) cannot be successfully used as a template by replicative DNA polymerase delta (POLD) and epsilon (POLE) complexes (Hoege et al. 2002). When the replication complex c...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Y-form DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA-dependent ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
 
negative regulation of DNA recombination IEA
Inferred from Electronic Annotation
more info
 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
 
protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
response to UV IBA
Inferred from Biological aspect of Ancestor
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Rad6-Rad18 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
XY body IEA
Inferred from Electronic Annotation
more info
 
chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase RAD18
Names
RAD18 homolog
RAD18, S. cerevisiae, homolog
RING finger protein 73
hHR18
hRAD18
postreplication repair protein RAD18
postreplication repair protein hRAD18p

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020165.3NP_064550.3  E3 ubiquitin-protein ligase RAD18

    See identical proteins and their annotated locations for NP_064550.3

    Status: REVIEWED

    Source sequence(s)
    AC008151, AC034186, AK023075, DW433240
    Consensus CDS
    CCDS2571.1
    UniProtKB/Swiss-Prot
    Q9NS91
    Related
    ENSP00000264926, OTTHUMP00000115649, ENST00000264926, OTTHUMT00000207071
    Conserved Domains (4) summary
    smart00734
    Location:201224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd00162
    Location:2563
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02037
    Location:248282
    SAP; SAP domain
    TIGR00599
    Location:13363
    rad18; DNA repair protein rad18

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    8877196..8963475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    8869168..8955418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)