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RAD18 RAD18 E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 56852, updated on 7-Dec-2014
Official Symbol
RAD18provided by HGNC
Official Full Name
RAD18 E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:18278
See related
Ensembl:ENSG00000070950; HPRD:09242; MIM:605256; Vega:OTTHUMG00000090545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF73
Summary
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
See RAD18 in Epigenomics, MapViewer
Location:
3p25-p24
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (8877196..8963475, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (8918880..9005159, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ssu-2 homolog (C. elegans) Neighboring gene caveolin 3 Neighboring gene oxytocin receptor Neighboring gene SLIT-ROBO Rho GTPase activating protein 3 Neighboring gene uncharacterized LOC101927416 Neighboring gene SRGAP3 antisense RNA 3

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 Integrase interacts with (co-immunoprecipitates) and co-localizes with hRad18 suggesting a role for hRad18 in the DNA repair events associated with the HIV-1 integration process PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Y-form DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
damaged DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of DNA recombination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
response to UV IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
XY body IEA
Inferred from Electronic Annotation
more info
 
chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase RAD18
Names
E3 ubiquitin-protein ligase RAD18
hHR18
hRAD18
RAD18 homolog
RING finger protein 73
RAD18, S. cerevisiae, homolog
postreplication repair protein RAD18
postreplication repair protein hRAD18p

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020165.3NP_064550.3  E3 ubiquitin-protein ligase RAD18

    See proteins identical to NP_064550.3

    Status: REVIEWED

    Source sequence(s)
    AC008151, AC034186, AK023075, DW433240
    Consensus CDS
    CCDS2571.1
    UniProtKB/Swiss-Prot
    Q9NS91
    Related
    ENSP00000264926, OTTHUMP00000115649, ENST00000264926, OTTHUMT00000207071
    Conserved Domains (4) summary
    smart00734
    Location:201224
    ZnF_Rad18; Rad18-like CCHC zinc finger
    TIGR00599
    Location:13363
    rad18; DNA repair protein rad18
    cd00162
    Location:2563
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
    pfam02037
    Location:248282
    SAP; SAP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    8877196..8963475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    8869168..8955418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    8853076..8939344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)