Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Aldh1a3provided by MGI
Official Full Name: aldehyde dehydrogenase family 1, subfamily A3provided by MGI
Primary source: MGI:1861722
See related: Ensembl:ENSMUSG00000015134; Vega:OTTMUSG00000036917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: V1; ALDH6; RALDH3

Genomic context

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Location :: 7 C; 7

Sequence :: Chromosome: 7; NC_000073.6 (66390892..66427477, complement)

See Aldh1a3 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

regulation of fat depots through the concerted action of Aldh1 enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 and PPARgamma in a depot-specific manner
Title: Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.
Kinetic characterization of RALDH3 and 4, providing their specificities for retinal isomer substrates.
Title: Kinetic characterization of recombinant mouse retinal dehydrogenase types 3 and 4 for retinal substrates.
Raldh2 and Raldh3 are selectively expressed in cortical stroma and in the ureteric bud during kidney development.
Title: Non-cell-autonomous retinoid signaling is crucial for renal development.
Three retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3), show differential expression patterns throughout later mouse organogenesis
Title: Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse.
RALDH3 (retinal dehydrogenase 3) was characterized by kinetic and binding studies, protein engineering, homology modelling, ligand docking and electrostatic-potential calculations.
Title: Characterization of retinaldehyde dehydrogenase 3.
The expression patterns of aldh1a2 and aldh1a3 retinoic acid synthesizing enzymes at specific follicular sites suggest that they mediate and are regulated by different epithelial proliferation and differentiation signaling pathways.
Title: Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation.
Raldh3 knockout suppresses retinoic acid synthesis and causes malformations restricted to ocular and nasal regions
Title: A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment.
the role of retinoic acid during forebrain development begins late when Raldh3 expression initiates in the ventral subventricular zone
Title: Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone.
RALDH3 is transiently expressed during early postnatal cortical development, suggesting an important role in cortical neuronal development.
Title: Retinoic acid synthesis in the postnatal mouse brain marks distinct developmental stages and functional systems.
During the first postnatal week, the RALDH3-expressing territory translocates in the caudal cortex from the medial limbic lobe to the adjacent neocortex and requires the neurotrophin NT-3.
Title: Retinoic acid delineates the topography of neuronal plasticity in postnatal cerebral cortex.

Submit: New GeneRIF Correction See all (11)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:208193	BioGRID:200780	Invs		BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Chemical carcinogenesis, organism-specific biosystem (from KEGG)
Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Chemical carcinogenesis, conserved biosystem (from KEGG)
Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Drug metabolism - cytochrome P450, organism-specific biosystem (from KEGG)
Drug metabolism - cytochrome P450, organism-specific biosystem
Drug metabolism - cytochrome P450
Drug metabolism - cytochrome P450, conserved biosystem (from KEGG)
Drug metabolism - cytochrome P450, conserved biosystem
Drug metabolism - cytochrome P450
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Histidine metabolism, organism-specific biosystem (from KEGG)
Histidine metabolism, organism-specific biosystem
Histidine metabolism
Histidine metabolism, conserved biosystem (from KEGG)
Histidine metabolism, conserved biosystem
Histidine metabolism
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
Metabolism of xenobiotics by cytochrome P450
Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, conserved biosystem
Metabolism of xenobiotics by cytochrome P450
Phenylalanine metabolism, organism-specific biosystem (from KEGG)
Phenylalanine metabolism, organism-specific biosystem
Phenylalanine metabolism
Phenylalanine metabolism, conserved biosystem (from KEGG)
Phenylalanine metabolism, conserved biosystem
Phenylalanine metabolism
Retinol metabolism, organism-specific biosystem (from WikiPathways)
Retinol metabolism, organism-specific biosystemThis pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities
Tyrosine metabolism, organism-specific biosystem (from KEGG)
Tyrosine metabolism, organism-specific biosystem
Tyrosine metabolism
Tyrosine metabolism, conserved biosystem (from KEGG)
Tyrosine metabolism, conserved biosystem
Tyrosine metabolism
beta-Alanine metabolism, organism-specific biosystem (from KEGG)
beta-Alanine metabolism, organism-specific biosystem
beta-Alanine metabolism
beta-Alanine metabolism, conserved biosystem (from KEGG)
beta-Alanine metabolism, conserved biosystem
beta-Alanine metabolism

General gene information

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Markers

PMC283541P1 (e-PCR)
- UniSTS:272407

20.MMHAP47FLG2.seq (e-PCR)
- UniSTS:123475

Aldh1a3 (e-PCR), detects polymorphism
- UniSTS:506722

Aldh1a3 (e-PCR), detects polymorphism
- UniSTS:525744

Aldh1a3 (e-PCR), detects polymorphism
- UniSTS:547811

Homology

Homologs of the Aldh1a3 gene: The Aldh1a3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
3-chloroallyl aldehyde dehydrogenase activity	TAS Traceable Author Statement more info	PubMed
NAD+ binding	IDA Inferred from Direct Assay more info	PubMed
aldehyde dehydrogenase (NAD) activity	IDA Inferred from Direct Assay more info	PubMed
aldehyde dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
aldehyde dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
thyroid hormone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
embryonic camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
embryonic eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
embryonic eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
face development	IGI Inferred from Genetic Interaction more info	PubMed
metabolic process	IEA Inferred from Electronic Annotation more info
nucleus accumbens development	IMP Inferred from Mutant Phenotype more info	PubMed
olfactory pit development	IMP Inferred from Mutant Phenotype more info	PubMed
optic cup morphogenesis involved in camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
oxidation-reduction process	IDA Inferred from Direct Assay more info	PubMed
oxidation-reduction process	ISO Inferred from Sequence Orthology more info
oxidation-reduction process	TAS Traceable Author Statement more info	PubMed
positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of retinoic acid receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
retinal metabolic process	ISO Inferred from Sequence Orthology more info
retinoic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
retinoic acid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
retinoic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldehyde dehydrogenase family 1 member A3

Names: aldehyde dehydrogenase family 1 member A3; RALDH-3; aldehyde dehydrogenase 6; aldehyde dehydrogenase-6; retinaldehyde dehydrogenase 3

NP_444310.3

EC 1.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053080.3 → NP_444310.3 aldehyde dehydrogenase family 1 member A3

Status: VALIDATED

Source sequence(s)

AK147006, BC038646

Consensus CDS

CCDS21345.1

UniProtKB/TrEMBL

Q3UIA4

UniProtKB/Swiss-Prot

Q9JHW9

Related

ENSMUSP00000015278, OTTMUSP00000052868, ENSMUST00000015278, OTTMUST00000094854

Conserved Domains (2) summary

cd07141
Location:26 – 506
Blast Score: 2366

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

pfam00171
Location:40 – 503
Blast Score: 1739

Aldedh; Aldehyde dehydrogenase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

66390892..66427477, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

63845586..63882073, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01062598.1 (4069..40556)	None
genomic	AC091324.10 (73490..117026)	None
genomic	CH466543.2	EDL07216.1	mixed
		EDL07217.1	mixed
		EDL07218.1	mixed
		EDL07219.1	mixed
mRNA	AF152359.1	AAG33935.1
mRNA	AF246711.1	AAG38488.1	C57BL/6J
mRNA	AF253409.1	AAF67736.1	B6.D2
mRNA	AF280404.1	AAF86980.1	129SvJ/C57Bl6
mRNA	AK043530.1	None	C57BL/6J
mRNA	AK086764.1	None	C57BL/6J
mRNA	AK147006.1	BAE27602.1	C57BL/6J
mRNA	BC026667.1	AAH26667.1	FVB/N-3
mRNA	BC038646.1	None	C57BL/6J
mRNA	BC048941.1	AAH48941.1	FVB/N-3
mRNA	BC058277.1	AAH58277.1	FVB/N-3