U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

usp11 ubiquitin specific peptidase 11 [ Danio rerio (zebrafish) ]

Gene ID: 568334, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
usp11provided by ZNC
Official Full Name
ubiquitin specific peptidase 11provided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-421
See related
Ensembl:ENSDARG00000076303 AllianceGenome:ZFIN:ZDB-GENE-081104-421
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-52h10.4
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 8
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (8643783..8683548)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (8605196..8644963)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene activator of basal transcription 1 Neighboring gene glutamate receptor, metabotropic 6a Neighboring gene zgc:86609 Neighboring gene ubiquitously-expressed, prefoldin-like chaperone

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11. Vlasschaert C, et al. BMC Evol Biol, 2015 Oct 26. PMID 26503449, Free PMC Article
  2. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase 11
XP_002663119.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    8643783..8683548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002663073.6 → XP_002663119.3  ubiquitin carboxyl-terminal hydrolase 11

    UniProtKB/TrEMBL
    A0A8M1RR50, F1QPF4
    Related
    ENSDARP00000070106.4, ENSDART00000075624.7
    Conserved Domains (6) summary
    COG5560
    Location:15 → 947
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:793 → 946
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:242 → 419
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:34 → 119
    DUSP; DUSP domain
    pfam14533
    Location:413 → 504
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:133 → 219
    Ubiquitin_3; Ubiquitin-like domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous