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ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 [ Homo sapiens (human) ]

Gene ID: 56829, updated on 26-May-2016
Official Symbol
ZC3HAV1provided by HGNC
Official Full Name
zinc finger CCCH-type containing, antiviral 1provided by HGNC
Primary source
HGNC:HGNC:23721
See related
Ensembl:ENSG00000105939 HPRD:09534; MIM:607312; Vega:OTTHUMG00000157471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2
Summary
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (139043520..139109720, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138728266..138794466, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene KIAA1549 Neighboring gene zinc finger CCCH-type containing, antiviral 1 like Neighboring gene ribosomal protein L17 pseudogene 28 Neighboring gene tetratricopeptide repeat domain 26 Neighboring gene male-specific lethal 3 homolog (Drosophila) pseudogene Neighboring gene FCF1 pseudogene 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated zinc finger CCCH-type, antiviral 1 (ZC3HAV1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with zinc finger CCCH-type, antiviral 1 (ZC3HAV1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger CCCH-type, antiviral 1 (ZC3HAV1) at amino acid residues 260-261 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13288, MGC48898, DKFZp686F2052, DKFZp686H1869, DKFZp686O19171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger CCCH-type antiviral protein 1
Names
ADP-ribosyltransferase diphtheria toxin-like 13
zinc finger CCCH domain-containing protein 2
zinc finger CCCH-type, antiviral 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029457.1 RefSeqGene

    Range
    5001..71200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020119.3NP_064504.2  zinc finger CCCH-type antiviral protein 1 isoform 1

    See identical proteins and their annotated locations for NP_064504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018644, AC083868, BC040956, BX571742, BX647974
    Consensus CDS
    CCDS5851.1
    UniProtKB/Swiss-Prot
    Q7Z2W4
    Related
    ENSP00000242351, OTTHUMP00000212199, ENST00000242351, OTTHUMT00000348915
    Conserved Domains (3) summary
    smart00678
    Location:607689
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:784893
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:727893
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  2. NM_024625.3NP_078901.3  zinc finger CCCH-type antiviral protein 1 isoform 2

    See identical proteins and their annotated locations for NP_078901.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several downstream exons, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC040956
    Consensus CDS
    CCDS55171.1
    UniProtKB/Swiss-Prot
    Q7Z2W4
    Related
    ENSP00000419855, OTTHUMP00000212201, ENST00000471652, OTTHUMT00000348917
    Conserved Domains (1) summary
    smart00678
    Location:607689
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    139043520..139109720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250501.1XP_005250558.1  

    UniProtKB/TrEMBL
    C9J6P4
    Related
    ENSP00000418385, OTTHUMP00000212200, ENST00000464606, OTTHUMT00000348916
    Conserved Domains (3) summary
    smart00678
    Location:729811
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:9061015
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:8491015
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  2. XM_011516412.1XP_011514714.1  

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    138662006..138728215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)