Pth1r parathyroid hormone 1 receptor [Rattus norvegicus] - Gene

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Summary

Official Symbol: Pth1rprovided by RGD
Official Full Name: parathyroid hormone 1 receptorprovided by RGD
Primary source: RGD:3442
See related: Ensembl:ENSRNOG00000020948
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Pthr; Pthr1; PTHrel

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Genomic context

Location :: 8q32

Sequence :: Chromosome: 8; NC_005107.2 (115099763..115119362, complement)

See Pth1r in MapViewer

Chromosome 8 - NC_005107.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains
Title: Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains.
This study demonstrates the dynamic expression of EBP50 in vessels following injury and the effects of EBP50 on PTH1R function in vascular smooth muscle cells.
Title: EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells.
These findings suggest that FGFR3 down-regulates PTH/PTHrP receptor gene expression via the JAK/STAT signaling in chondrocytic cells.
Title: FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line.
Downregulation of PTHrP and PTHrP-R gene expression during late lung morphogenesis may cause pulmonary hypoplasia in the nitrofen CDH model, disrupting alveolar maturation and surfactant production by interfering with mesenchymal-epithelial interactions.
Title: Disturbance of parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung.
The regulation of PTH1R expression by endogenous PTHrP and the associated effects on vascular smooth muscle cell proliferation, was investigated.
Title: Endogenous parathyroid hormone-related protein regulates the expression of PTH type 1 receptor and proliferation of vascular smooth muscle cells.
NHERF1 inhibited beta-arrestin2 binding to wtPTH1R but had no effect on beta-arrestin2 association with pdPTH1R. Such an effect may protect against PTH resistance or PTH1R down-regulation in cells harboring NHERF1.
Title: NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.
PTH signaling to PLC is negatively regulated by PTH/PTHrP receptor phosphorylation and PKA.
Title: Negative regulation of parathyroid hormone (PTH)-activated phospholipase C by PTH/PTH-related peptide receptor phosphorylation and protein kinase A.
Studies proposed that, in ROS cells, the presence of NHERF1 induces PTH-dependent calcium signaling by a cAMP-mediated mechanism that involves local protein kinase A-dependent activation of calcium channels.
Title: Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells.
Defective transport of mutant PTH receptor(Pro132Leu) to the experimental cell surface indicate a molecular basis for Blomstrand's chondrodysplasia.
Title: Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R(P132L) show the different intracellular localization in vitro.
Results conclude that PTH and PTHrP bind similarly to the G protein-coupled PTHR conformation, PTH has a greater capacity to bind to the G protein-uncoupled conformation.
Title: Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.

Submit: New GeneRIF Correction See all (19)

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:248587	BioGRID:246428	Calm1		BioGRID	PubMed	Reconstituted Complex
BioGRID:248587	BioGRID:113164	UBC		BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
parathyroid hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
parathyroid hormone receptor activity	ISO Inferred from Sequence Orthology more info
peptide hormone binding	ISO Inferred from Sequence Orthology more info
peptide hormone binding	ISS Inferred from Sequence or Structural Similarity more info
protein self-association	IEA Inferred from Electronic Annotation more info
protein self-association	ISO Inferred from Sequence Orthology more info
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein signaling, coupled to cAMP nucleotide second messenger	ISO Inferred from Sequence Orthology more info
activation of adenylate cyclase activity by G-protein signaling pathway	IEA Inferred from Electronic Annotation more info
activation of adenylate cyclase activity by G-protein signaling pathway	ISO Inferred from Sequence Orthology more info
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	IEA Inferred from Electronic Annotation more info
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	ISO Inferred from Sequence Orthology more info
aging	IEP Inferred from Expression Pattern more info	PubMed
bone mineralization	IEA Inferred from Electronic Annotation more info
bone mineralization	ISO Inferred from Sequence Orthology more info
bone resorption	IEA Inferred from Electronic Annotation more info
bone resorption	ISO Inferred from Sequence Orthology more info
cell maturation	IEA Inferred from Electronic Annotation more info
cell maturation	ISO Inferred from Sequence Orthology more info
cellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
cellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
elevation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
ossification	ISO Inferred from Sequence Orthology more info
osteoblast development	IEA Inferred from Electronic Annotation more info
osteoblast development	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
skeletal system development	IEA Inferred from Electronic Annotation more info
skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
brush border membrane	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral to plasma membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	ISO Inferred from Sequence Orthology more info
intracellular	IEA Inferred from Electronic Annotation more info
intracellular	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: parathyroid hormone/parathyroid hormone-related peptide receptor

Names: parathyroid hormone/parathyroid hormone-related peptide receptor; PTH1 receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; parathyroid hormone receptor 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020073.2 → NP_064458.1 parathyroid hormone/parathyroid hormone-related peptide receptor precursor

Status: PROVISIONAL

Source sequence(s)

L19475

UniProtKB/Swiss-Prot

P25961

Related

ENSRNOP00000028435, ENSRNOT00000028435

Conserved Domains (2) summary

cl02422
Location:105 – 170
Blast Score: 233

HRM; Hormone receptor domain

cl12142
Location:184 – 455
Blast Score: 801

7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005107.2 Reference assembly (based on RGSC_v3.4)

Range

115099763..115119362, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000076.1 Alternate assembly (Rn_Celera)

Range

109981641..110001215, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AB012944.1	BAA36563.1	Sprague-Dawley
genomic	CH473954.2	EDL77061.1
		EDL77062.1
		EDL77063.1
genomic	L31381.1	None
genomic	L31385.1	None
mRNA	L19475.1	AAA68098.1
mRNA	M77184.1	AAA41811.1