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    PSKH1 protein serine kinase H1 [ Homo sapiens ]

    Gene ID: 5681, updated on 11-May-2012
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    Summary

    Official Symbol
    PSKH1provided by HGNC
    Official Full Name
    protein serine kinase H1provided by HGNC
    Primary source
    HGNC:9529
    See related
    Ensembl:ENSG00000159792; HPRD:01511; MIM:177015; Vega:OTTHUMG00000137548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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    Genomic context

    Location :
    16q22.1
    Sequence :
    Chromosome: 16; NC_000016.9 (67927175..67963581)
    See PSKH1 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like Neighboring gene chymotrypsin-like Neighboring gene proteasome (prosome, macropain) subunit, beta type, 10 Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 4 Neighboring gene lecithin-cholesterol acyltransferase

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus. Brede G, et al. Exp Cell Res, 2003 Dec 10. PMID 14644153.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. PSKH1, a novel splice factor compartment-associated serine kinase. Brede G, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466556.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A minimal region required for proper Golgi targeting of PSKH1 was identified within the first 29 amino acids; and structural and regulatory role of PSKH1 in maintenance of the Golgi apparatus is determined
      Title: Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P11801 Q99741 CDC6    HPRD  PubMed  
    BioGRID:111654 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular_component ND
    No biological Data available
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase H1
    Names
    serine/threonine-protein kinase H1
    PSK-H1
    NP_006733.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006742.2 → NP_006733.1  serine/threonine-protein kinase H1

      Status: VALIDATED

      Source sequence(s)
      AJ272212, BC062616, DA429976
      Consensus CDS
      CCDS10851.1
      UniProtKB/Swiss-Prot
      P11801
      Related
      ENSP00000291041, OTTHUMP00000174853, ENST00000291041, OTTHUMT00000268882
      Conserved Domains (2) summary
      cd05123
      Location:104 – 354
      Blast Score: 629
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:98 – 355
      Blast Score: 801
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      67927175..67963581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      53800311..53837151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC040162.5 (86199..122565) None
    genomic CH471092.1 EAW83185.1
    mRNA AJ272212.1 CAB91984.1
    mRNA AK309272.1 None
    mRNA BC021584.1 None
    mRNA BC037560.1 None
    mRNA BC062616.1 AAH62616.1
    mRNA DA429976.1 None
    mRNA M14504.1 AAA36519.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11801.4 GenPept UniProtKB/Swiss-Prot:P11801
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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