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eif4g3a eukaryotic translation initiation factor 4 gamma, 3a [ Danio rerio (zebrafish) ]

Gene ID: 566131, updated on 27-Mar-2024

Summary

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Official Symbol
eif4g3aprovided by ZNC
Official Full Name
eukaryotic translation initiation factor 4 gamma, 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120810-2
See related
Ensembl:ENSDARG00000077215 AllianceGenome:ZFIN:ZDB-GENE-120810-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
eif4g3
Summary
Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be part of eukaryotic translation initiation factor 4F complex. Orthologous to human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (27828830..27917661, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (27581656..27670520, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene Cas scaffold protein family member 4 Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene endothelin converting enzyme 1 Neighboring gene alkaline phosphatase, biomineralization associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development. Ohlebusch B, et al. Sci Rep, 2020 Aug 7. PMID 32770041, Free PMC Article
  2. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4 gamma 3
Names
eukaryotic translation initiation factor 4 gamma, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    27828830..27917661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306089.3 → XP_009304364.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3BDQ6
    Conserved Domains (4) summary
    cd11559
    Location:1550 → 1685
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1351 → 1462
    MA3; MA3 domain
    pfam02854
    Location:879 → 1107
    MIF4G; MIF4G domain
    pfam11235
    Location:18 → 172
    Med25_SD1; Mediator complex subunit 25 synapsin 1

  2. XM_689398.8 → XP_694490.5  eukaryotic translation initiation factor 4 gamma 3 isoform X3

    UniProtKB/TrEMBL
    A0A140LGN9, A0A8N7UV45
    Related
    ENSDARP00000142418.1, ENSDART00000173219.2
    Conserved Domains (4) summary
    cd11559
    Location:1547 → 1682
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1348 → 1459
    MA3; MA3 domain
    pfam02854
    Location:876 → 1104
    MIF4G; MIF4G domain
    pfam11235
    Location:18 → 172
    Med25_SD1; Mediator complex subunit 25 synapsin 1

  3. XM_009306090.3 → XP_009304365.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AXN1
    Conserved Domains (4) summary
    cd11559
    Location:1548 → 1683
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:1349 → 1460
    MA3; MA3 domain
    pfam02854
    Location:877 → 1105
    MIF4G; MIF4G domain
    pfam11235
    Location:18 → 172
    Med25_SD1; Mediator complex subunit 25 synapsin 1
Nucleotide Protein Strain
Heading Accession and Version

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