Sec11a SEC11 homolog A (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Sec11aprovided by MGI
Official Full Name: SEC11 homolog A (S. cerevisiae)provided by MGI
Primary source: MGI:1929464
See related: Ensembl:ENSMUSG00000025724; Vega:OTTMUSG00000031331
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 18kDa; Spc18; Sec11l1; sid2895; Sid2895p; 1810012E07Rik

Genomic context

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Location :: 7 D3; 7

Sequence :: Chromosome: 7; NC_000073.6 (80915379..80947550, complement)

See Sec11a in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Pathways from BioSystems

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Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem (from REACTOME)
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein export, organism-specific biosystem (from KEGG)
Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
Protein export, conserved biosystem (from KEGG)
Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH129975 (e-PCR)
- UniSTS:213263

38.MMHAP97FRE11.seq (e-PCR)
- UniSTS:124305

Homology

Homologs of the Sec11a gene: The Sec11a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
hydrolase activity	IEA Inferred from Electronic Annotation more info
peptidase activity	IEA Inferred from Electronic Annotation more info
serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info
proteolysis	IEA Inferred from Electronic Annotation more info
signal peptide processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal peptidase complex catalytic subunit SEC11A

Names: signal peptidase complex catalytic subunit SEC11A; sid 2895; Sec11-like 1; endopeptidase SP18; SEC11-like protein 1; SPase 18 kDa subunit; signal peptidase complex (18kD); microsomal signal peptidase 18 kDa subunit

NP_064335.1

EC 3.4.21.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019951.1 → NP_064335.1 signal peptidase complex catalytic subunit SEC11A

Status: PROVISIONAL

Source sequence(s)

AB025405

Consensus CDS

CCDS21401.1

UniProtKB/Swiss-Prot

Q9R0P6

Related

ENSMUSP00000026818, OTTMUSP00000041093, ENSMUST00000026818, OTTMUST00000077614

Conserved Domains (1) summary

cd06530
Location:48 – 142
Blast Score: 180

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

80915379..80947550, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

78323962..78356116, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01063557.1 (38549..70703)	None
genomic	AC123744.8 (55806..87977)	None
genomic	CH466543.2	EDL06962.1	mixed
		EDL06963.1	mixed
		EDL06964.1	mixed
		EDL06965.1	mixed
		EDL06966.1	mixed
mRNA	AB025405.1	BAA84690.1
mRNA	AK007449.1	BAB25044.1	C57BL/6J
mRNA	AK169560.1	None	C57BL/6J
mRNA	AK184425.1	None
mRNA	BC010484.1	AAH10484.1
mRNA	BC057885.1	AAH57885.1	FVB/N