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Pard6a par-6 family cell polarity regulator alpha [ Mus musculus (house mouse) ]

Gene ID: 56513, updated on 8-May-2016
Official Symbol
Pard6aprovided by MGI
Official Full Name
par-6 family cell polarity regulator alphaprovided by MGI
Primary source
MGI:MGI:1927223
See related
Ensembl:ENSMUSG00000005699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Par6; Par-6; Par6c; TAX40; PAR-6A; Tip-40; PAR6alpha; 0710008C04Rik; 2610010A15Rik
Orthologs
Location:
8; 8 D2
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (105701148..105703494)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108225054..108227394)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene CCCTC-binding factor Neighboring gene predicted gene, 33578 Neighboring gene RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing Neighboring gene adrenocortical dysplasia Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene enkurin domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Rho GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction maintenance IDA
Inferred from Direct Assay
more info
PubMed 
establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
partitioning defective 6 homolog alpha
Names
PAR-6 alpha
Tax interaction protein 40
par-6 (partitioning defective 6,) homolog alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047435.2NP_001040900.1  partitioning defective 6 homolog alpha isoform 2

    See identical proteins and their annotated locations for NP_001040900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC152826, AK158848, BF466814
    UniProtKB/Swiss-Prot
    Q9Z101
    UniProtKB/TrEMBL
    Q3TY70
    Conserved Domains (2) summary
    cd06403
    Location:1695
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:155246
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001047436.2NP_001040901.1  partitioning defective 6 homolog alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon. This encodes a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC152826, AK158848, BF466814, CX220562
    Consensus CDS
    CCDS40462.1
    UniProtKB/TrEMBL
    D3Z2R1, Q3TY70
    Related
    ENSMUSP00000096043, ENSMUST00000098444
    Conserved Domains (2) summary
    cd00992
    Location:140231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02720
    Location:579
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
  3. NM_001286344.1NP_001273273.1  partitioning defective 6 homolog alpha isoform 4

    See identical proteins and their annotated locations for NP_001273273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon. This encodes a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AK158848, BF466814, BY099545, CK618363
    UniProtKB/TrEMBL
    Q3TY70
    Conserved Domains (1) summary
    cd00992
    Location:971
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001286345.1NP_001273274.1  partitioning defective 6 homolog alpha isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region, compared to variant 1. This encodes a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC152826, AK158848, BF466814, CX206739
    UniProtKB/TrEMBL
    Q3TY70
    Conserved Domains (2) summary
    cd00992
    Location:126217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02720
    Location:1669
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
  5. NM_019695.3NP_062669.2  partitioning defective 6 homolog alpha isoform 1

    See identical proteins and their annotated locations for NP_062669.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC152826, AK158848, BF466814, CX206739
    Consensus CDS
    CCDS22609.1
    UniProtKB/Swiss-Prot
    Q9Z101
    UniProtKB/TrEMBL
    Q3TY70
    Related
    ENSMUSP00000090886, ENSMUST00000093195
    Conserved Domains (2) summary
    cd06403
    Location:1695
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:156247
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    105701148..105703494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531211.1XP_006531274.1  

    Conserved Domains (2) summary
    cd00992
    Location:139230
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02720
    Location:579
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
  2. XM_006531212.2XP_006531275.1  

    See identical proteins and their annotated locations for XP_006531275.1

    Conserved Domains (1) summary
    cd00992
    Location:971
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    109926066..109928412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)