trmt12 tRNA methyltransferase 12 homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: trmt12provided by ZNC
Official Full Name: tRNA methyltransferase 12 homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060825-182
See related: Ensembl:ENSDARG00000060338 AllianceGenome:ZFIN:ZDB-GENE-060825-182
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153361; CH73-188I6.1
Summary: Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within exocytosis and tRNA processing. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (35414632..35422774)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (35074318..35082460)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in wybutosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA wybutosine-synthesizing protein 2 homolog

Names: alpha-amino-alpha-carboxypropyl transferase TYW2; homolog of yeast tRNA methyltransferase 12; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2

NP_001070632.1

EC 2.5.1.114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077164.1 → NP_001070632.1 tRNA wybutosine-synthesizing protein 2 homolog

See identical proteins and their annotated locations for NP_001070632.1

Status: PROVISIONAL

Source sequence(s)

BC122254

UniProtKB/Swiss-Prot

Q0P466

Related

ENSDARP00000079349.5, ENSDART00000084914.6

Conserved Domains (2) summary

COG2520
Location:2 → 407

Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

cl17173
Location:220 → 268

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...