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    EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Homo sapiens ]

    Gene ID: 56478, updated on 11-May-2012
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    Summary

    Official Symbol
    EIF4ENIF1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E nuclear import factor 1provided by HGNC
    Primary source
    HGNC:16687
    Locus tag
    RP11-247I13.2
    See related
    Ensembl:ENSG00000184708; HPRD:10456; MIM:607445; Vega:OTTHUMG00000030793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    4E-T; Clast4; FLJ21601; FLJ26551
    Summary
    The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
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    Genomic context

    Location :
    22q11.2
    Sequence :
    Chromosome: 22; NC_000022.10 (31835345..31885874, complement)
    See EIF4ENIF1 in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein FLJ20464 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene H2A histone family, member Z pseudogene 6 Neighboring gene ribosomal protein S18 pseudogene 14

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. Suzuki Y, et al. J Biol Chem, 2009 Dec 18. PMID 19850929.
    2. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.
    3. Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation. Lee HC, et al. Biochem Biophys Res Commun, 2008 May 16. PMID 18343217.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Hsp90 probably contributes to the correct localization of eIF4E and 4E-T to stress granules and also to the interaction between eIF4E and eIF4G, both of which may be needed for eIF4E to acquire the physiological functionality
      Title: The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.
    2. Overexpression of eIF4E-T triggers the movement of eIF4E into the processing bodies.
      Title: Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation.
    3. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay is described.
      Title: A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay.
    4. human P bodies contain the cap-binding protein eIF4E and the related factor eIF4E-transporter (eIF4E-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation
      Title: A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_062817.1 NP_005893.1 SMAD3    BIND  PubMed Smad3 interacts with 4-ET. This interaction was modeled on a demonstrated interaction between human Smad3 and mouse 4-ET. 
    Q9NRA8 P54253 ATXN1    HPRD  PubMed  
    Q9NRA8 P60228 EIF3E    HPRD  PubMed  
    Q9NRA8 P06730 EIF4E    HPRD  PubMed  
    Q9NRA8 O60573 EIF4E2    HPRD  PubMed  
    Q9NRA8 P84022 SMAD3    HPRD  PubMed  
    Q9NRA8 Q96R06 SPAG5    HPRD  PubMed  
    BioGRID:121148 BioGRID:107076 BCL6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121148 BioGRID:108292 EIF4E    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:121148 BioGRID:114856 EIF4E2    BioGRID  PubMed Two-hybrid 
    BioGRID:121148 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E transporter
    Names
    eukaryotic translation initiation factor 4E transporter
    2610509L04Rik
    eIF4E transporter
    eIF4E-transporter
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164501.1 → NP_001157973.1  eukaryotic translation initiation factor 4E transporter isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AA609351, AK314636, BC032941, BC033028, DA336484
      Consensus CDS
      CCDS13898.1
      UniProtKB/Swiss-Prot
      Q9NRA8
      Related
      ENSP00000380659, OTTHUMP00000063276, ENST00000397525, OTTHUMT00000127926
      Conserved Domains (1) summary
      pfam10477
      Location:30 – 333
      Blast Score: 698
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    2. NM_001164502.1 → NP_001157974.1  eukaryotic translation initiation factor 4E transporter isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame segment in the coding region compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA609351, AK314636, BC032941
      Consensus CDS
      CCDS54520.1
      UniProtKB/TrEMBL
      B1AKL3
      UniProtKB/Swiss-Prot
      Q9NRA8
      Related
      ENSP00000342927, OTTHUMP00000063275, ENST00000344710, OTTHUMT00000127925
      Conserved Domains (1) summary
      pfam10477
      Location:30 – 99
      Blast Score: 239
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    3. NM_019843.3 → NP_062817.2  eukaryotic translation initiation factor 4E transporter isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AA609351, AK314636, BC032941
      Consensus CDS
      CCDS13898.1
      UniProtKB/Swiss-Prot
      Q9NRA8
      Related
      ENSP00000328103, OTTHUMP00000028884, ENST00000330125, OTTHUMT00000075681
      Conserved Domains (1) summary
      pfam10477
      Location:30 – 333
      Blast Score: 698
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      31835345..31885874, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      14796261..14846685, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL096701.14 CAI12877.1
      CAI12878.1
      CAI12879.1
      CAI12880.1
      CAM14699.1
      CAQ08084.1
    genomic CH471095.1 EAW59977.1
      EAW59978.1
      EAW59979.1
    mRNA AA609351.1 None
    mRNA AF240775.1 AAF81693.1
    mRNA AK025254.1 BAB15092.1
    mRNA AK074768.1 BAC11194.1
    mRNA AK130061.1 None
    mRNA AK299136.1 BAG61188.1
    mRNA AK314636.1 BAG37198.1
    mRNA BC012734.2 AAH12734.1
    mRNA BC032941.1 AAH32941.1
    mRNA BC033028.1 AAH33028.1
    mRNA CR456386.1 CAG30272.1
    mRNA DA336484.1 None
    mRNA DQ655937.2 None
    mRNA DQ656044.2 None
    other-genetic CU012945.1 CAK54376.1
    other-genetic CU013233.1 CAK54675.1
    other-genetic DQ892481.2 ABM83407.1
    other-genetic DQ895692.2 ABM86618.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PJR2 GenPept UniProtKB/TrEMBL:Q6PJR2
    Q9NRA8.2 GenPept UniProtKB/Swiss-Prot:Q9NRA8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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