Format

Send to:

Choose Destination

Socs5 suppressor of cytokine signaling 5 [ Mus musculus (house mouse) ]

Gene ID: 56468, updated on 28-May-2016
Official Symbol
Socs5provided by MGI
Official Full Name
suppressor of cytokine signaling 5provided by MGI
Primary source
MGI:MGI:2385459
See related
Ensembl:ENSMUSG00000037104
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cish5; mKIAA0671; 1810018L08Rik
Orthologs
Location:
17; 17 E4
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (87107407..87137647)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (87507019..87536925)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 14 pseudogene Neighboring gene predicted gene, 30510 Neighboring gene RIKEN cDNA C330024C12 gene Neighboring gene predicted gene, 41647

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ECS complex, organism-specific biosystem (from KEGG)
    ECS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
  • ECS complex, conserved biosystem (from KEGG)
    ECS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
  • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 signaling Pathway, organism-specific biosystem
    IL-4 signaling Pathway
  • JAK-STAT signaling, organism-specific biosystem (from KEGG)
    JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • JAK-STAT signaling, conserved biosystem (from KEGG)
    JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0671

Gene Ontology Provided by MGI

Function Evidence Code Pubs
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
cell growth NAS
Non-traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of T-helper 1 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
suppressor of cytokine signaling 5
Names
SOCS-5
cytokine inducible SH2-containing protein 5
cytokine-inducible SH2-containing protein 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019654.2NP_062628.2  suppressor of cytokine signaling 5

    See identical proteins and their annotated locations for NP_062628.2

    Status: PROVISIONAL

    Source sequence(s)
    BC053015
    Consensus CDS
    CCDS29014.1
    UniProtKB/Swiss-Prot
    O54928
    Related
    ENSMUSP00000038591, ENSMUST00000041369
    Conserved Domains (3) summary
    cd03739
    Location:479534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:144198
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370470
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    87107407..87137647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524674.2XP_006524737.1  

    See identical proteins and their annotated locations for XP_006524737.1

    UniProtKB/Swiss-Prot
    O54928
    Conserved Domains (3) summary
    cd03739
    Location:479534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:144198
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370470
    SH2; Src homology 2 (SH2) domain
  2. XM_006524672.2XP_006524735.1  

    See identical proteins and their annotated locations for XP_006524735.1

    UniProtKB/Swiss-Prot
    O54928
    Conserved Domains (3) summary
    cd03739
    Location:479534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:144198
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370470
    SH2; Src homology 2 (SH2) domain
  3. XM_006524671.2XP_006524734.1  

    See identical proteins and their annotated locations for XP_006524734.1

    UniProtKB/Swiss-Prot
    O54928
    Conserved Domains (3) summary
    cd03739
    Location:479534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:144198
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370470
    SH2; Src homology 2 (SH2) domain
  4. XM_006524675.2XP_006524738.1  

    See identical proteins and their annotated locations for XP_006524738.1

    UniProtKB/Swiss-Prot
    O54928
    Conserved Domains (3) summary
    cd03739
    Location:479534
    SOCS_SOCS5; SOCS (suppressors of cytokine signaling) box of SOCS5-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS5 inhibits Th2 differentiation by inhibiting ...
    pfam12610
    Location:144198
    SOCS; Suppressor of cytokine signalling
    cl15255
    Location:370470
    SH2; Src homology 2 (SH2) domain

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    91484878..91514794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)