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PRSS3 protease, serine 3 [ Homo sapiens (human) ]

Gene ID: 5646, updated on 26-May-2016
Official Symbol
PRSS3provided by HGNC
Official Full Name
protease, serine 3provided by HGNC
Primary source
HGNC:HGNC:9486
See related
Ensembl:ENSG00000010438 HPRD:06685; MIM:613578; Vega:OTTHUMG00000019798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T9; MTG; TRY3; TRY4; PRSS4
Summary
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Orthologs
Location:
9p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (33750466..33799231)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33750464..33799229)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene T cell receptor beta variable 26/OR9-2 (pseudogene) Neighboring gene uncharacterized LOC102724216 Neighboring gene long intergenic non-protein coding RNA 1251 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene ubiquitin conjugating enzyme E2 R2 Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene ubiquitin associated protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
NHGRI GWA Catalog
  • Alpha-defensins, organism-specific biosystem (from REACTOME)
    Alpha-defensins, organism-specific biosystemHumans have 7 alpha defensin genes plus 5 pseudogenes (see HGNC at http://www.genenames.org/genefamilies/DEFA). Alpha-defensins have six cysteines linked 1-6, 2-4, 3-5. The canonical sequence of alph...
  • Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystem (from REACTOME)
    Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystemVitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating wi...
  • Defensins, organism-specific biosystem (from REACTOME)
    Defensins, organism-specific biosystemThe defensins are a family of antimicrobial cationic peptide molecules which in mammals have a characteristic beta-sheet-rich fold and framework of six disulphide-linked cysteines (Selsted & Ouellet...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type peptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cobalamin metabolic process TAS
Traceable Author Statement
more info
 
digestion TAS
Traceable Author Statement
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
zymogen activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
trypsin-3
Names
brain trypsinogen
mesotrypsin
mesotrypsinogen
pancreatic trypsinogen III
protease, serine, 4 (trypsin 4, brain)
trypsin III
trypsin IV
trypsinogen 4
trypsinogen 5
trypsinogen IV
NP_001184026.2
NP_001184027.1
NP_002762.2
NP_031369.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001337.2 

    Range
    144006..192771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_029635.1 RefSeqGene

    Range
    5001..53766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197097.2NP_001184026.2  trypsin-3 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001184026.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB298285, AB298286, AY052783
    Consensus CDS
    CCDS56571.1
    UniProtKB/Swiss-Prot
    P35030
    UniProtKB/TrEMBL
    Q7Z5F4
    Related
    ENSP00000340889, ENST00000342836
    Conserved Domains (2) summary
    smart00020
    Location:37253
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:38256
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001197098.1NP_001184027.1  trypsin-3 isoform 4 preproprotein

    See identical proteins and their annotated locations for NP_001184027.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different in-frame first exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB298286
    Consensus CDS
    CCDS56570.1
    UniProtKB/Swiss-Prot
    P35030
    Related
    ENSP00000401828, ENST00000429677
    Conserved Domains (2) summary
    smart00020
    Location:16232
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:17235
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_002771.3NP_002762.2  trypsin-3 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_002762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB298285, BC069494
    Consensus CDS
    CCDS6545.1
    UniProtKB/Swiss-Prot
    P35030
    Related
    ENSP00000368715, OTTHUMP00000021239, ENST00000379405, OTTHUMT00000052122
    Conserved Domains (2) summary
    smart00020
    Location:23239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:24242
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_007343.3NP_031369.2  trypsin-3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_031369.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB298285
    Consensus CDS
    CCDS47958.1
    UniProtKB/Swiss-Prot
    P35030
    Related
    ENSP00000354280, OTTHUMP00000021238, ENST00000361005, OTTHUMT00000052121
    Conserved Domains (2) summary
    smart00020
    Location:80296
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:81299
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    33750466..33799231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517965.1XP_011516267.1  

    Conserved Domains (2) summary
    smart00020
    Location:109325
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:110328
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    33750270..33799034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)