Foxo1 forkhead box O1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Foxo1provided by MGI
Official Full Name: forkhead box O1provided by MGI
Primary source: MGI:1890077
See related: Ensembl:ENSMUSG00000044167; Vega:OTTMUSG00000021250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Afxh; FKHR; Fkhr1; Foxo1a; AI876417

Genomic context

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Location :: 3 C; 3 23.19 cM

Sequence :: Chromosome: 3; NC_000069.6 (52268337..52350109)

See Foxo1 in Epigenomics, MapViewer

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

FoxO1 is required specifically in endothelial cells to regulate formation of the heart and vasculature during development
Title: FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development.
Constitutively active FOXO1 can rescue the hypoglycemic effect caused by reduced hepatic MKP-3 expression in vivo.
Title: Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis.
PTEN-mediated Akt/beta-catenin/Foxo1 axis a key regulator of innate inflammatory response in the mouse liver
Title: PTEN-mediated Akt/β-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury.
EBF1 and FOXO1 act in a positive feedback circuitry to promote and stabilize specification to the B-cell lineage
Title: Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.
Results show that FoxO1 directly binds to the genomic sites for the genes in retinoid metabolism.
Title: Genome-wide analysis of FoxO1 binding in hepatic chromatin: potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis.
Atg14 is a new target gene of FoxOs and the core clock machinery, and this gene plays an important role in hepatic lipid metabolism
Title: The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism.
FOXO1 is the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation.
Title: FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.
findings show that the evolutionarily ancient Akt-Foxo1 signalling module controls a novel genetic program indispensable for T(reg) cell function
Title: Novel Foxo1-dependent transcriptional programs control T(reg) cell function.
It was shown that expressed Foxo3A-green fluorescent protein shuttles ~20-fold more slowly than Foxo1-green fluorescent protein.
Title: Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers.
Foxo1 ablation enhanced the glucose-stimulated insulin secretion at high glucose concentrations and enhanced beta-cell proliferation.
Title: Analysis of Foxo1-regulated genes using Foxo1-deficient pancreatic β cells.

Submit: New GeneRIF Correction See all (208)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (5) 1 citation
Targeted (knock-out) (3) 1 citation
Targeted (Reporter) (2) 1 citation
Gene trapped (1)
Targeted (knock-in) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_062713.2	NP_033782.1	Akt1	BIND	PubMed	Akt1 phosphorylates FKHR1.
NP_062713.2	NP_062713.2	Foxo1	BIND	PubMed	Foxo1 interacts with another copy of itself. This interaction was modeled on a demonstrated interaction between human Foxo1 molecules.
NP_062713.2	NC_000077.1	G6pc	BIND	PubMed	Foxo1 interacts with chromatin of the G6pc locus, via G6pc's IRU (Insulin Response Unit) within the promoter region.
NP_062713.2	NP_032287.2	Hnf4a	BIND	PubMed	Foxo1 interacts with Hnf4a. This interaction was modeled on a demonstrated interaction between human Foxo1 and Hnf4a from an unspecified species.
NP_062713.2	NC_000068.1	Pck1	BIND	PubMed	Foxo1 interacts with the Pck1 (PEPCK) promoter.
NP_062713.2	NP_032930.1	Ppargc1a	BIND	PubMed	Foxo1 interacts with Ppargc1a. This interaction was modeled on a demonstrated interaction between human Foxo1 and mouse Ppargc1a.
BioGRID:207997	BioGRID:232691	Bsx	BioGRID	PubMed	Affinity Capture-Western
BioGRID:207997	BioGRID:215365	Lrpprc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:207997	BioGRID:204818	Nr0b2	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:207997	BioGRID:204340	Tsc2	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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AKT phosphorylates targets in the nucleus, organism-specific biosystem (from REACTOME)
AKT phosphorylates targets in the nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
AKT-mediated inactivation of FOXO1A, organism-specific biosystem (from REACTOME)
AKT-mediated inactivation of FOXO1A, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-7 Signaling Pathway, organism-specific biosystem
IL-7 Signaling Pathway
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Insulin signaling pathway, organism-specific biosystem (from KEGG)
Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Insulin signaling pathway, conserved biosystem (from KEGG)
Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI-3K cascade, organism-specific biosystem (from REACTOME)
PI-3K cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
PI3K/Akt/mTOR signaling pathway
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Regulation of beta-cell development, organism-specific biosystem (from REACTOME)
Regulation of beta-cell development, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of gene expression in beta cells, organism-specific biosystem (from REACTOME)
Regulation of gene expression in beta cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer

General gene information

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Markers

Foxo1 (e-PCR), detects polymorphism
- UniSTS:530689

Foxo1 (e-PCR), detects polymorphism
- UniSTS:480325

D3Mit207 (e-PCR), detects polymorphism
- UniSTS:129628

Foxo1 (e-PCR), detects polymorphism
- UniSTS:515966

RH74854 (e-PCR)
- UniSTS:92039

AI876417 (e-PCR)
- UniSTS:178832

NoName (e-PCR)
- UniSTS:234675

Homology

Homologs of the Foxo1 gene: The Foxo1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding, bending	IBA Inferred from Biological aspect of Ancestor more info
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
protein phosphatase 2A binding	IDA Inferred from Direct Assay more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to nitric oxide	IDA Inferred from Direct Assay more info
cellular response to oxidative stress	IDA Inferred from Direct Assay more info
embryo development	IBA Inferred from Biological aspect of Ancestor more info
insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
organ development	IBA Inferred from Biological aspect of Ancestor more info
pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
response to DNA damage stimulus	IBA Inferred from Biological aspect of Ancestor more info
response to DNA damage stimulus	IDA Inferred from Direct Assay more info
tissue development	IBA Inferred from Biological aspect of Ancestor more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	IBA Inferred from Biological aspect of Ancestor more info
cytosol	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: forkhead box protein O1

Names: forkhead box protein O1; forkhead box O1a; forkhead protein 1; forkhead box protein O1A; forkhead in rhabdomyosarcoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019739.3 → NP_062713.2 forkhead box protein O1

Status: VALIDATED

Source sequence(s)

AC104932, AC163092

Consensus CDS

CCDS17343.1

UniProtKB/Swiss-Prot

Q9R1E0

Related

ENSMUSP00000055308, OTTMUSP00000023486, ENSMUST00000053764, OTTMUST00000050335

Conserved Domains (1) summary

cd00059
Location:157 – 237
Blast Score: 279

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000069.6 Reference GRCm38.p1 C57BL/6J

Range

52268337..52350109

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000025.1 Alternate Mm_Celera

Range

52001471..52082927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01026719.1	None
genomic	AAHY01026720.1	None
genomic	AAHY01026721.1	None
genomic	AAHY01026722.1	None
genomic	AAHY01026723.1	None
genomic	AAHY01026724.1	None
genomic	AC104932.22 (116091..184718)	None
genomic	AC163092.4 (77310..90454)	None
genomic	CH466530.1	EDL35224.1	mixed
mRNA	AF114258.1	AAD42106.1
mRNA	AF126056.1	AAD40636.1
mRNA	AJ252157.1	CAB86873.1
mRNA	AK029013.1	None	C57BL/6J
mRNA	AK030304.1	None	C57BL/6J
mRNA	AK039265.1	BAC30298.1	C57BL/6J
mRNA	AK043583.1	BAC31588.1	C57BL/6J
mRNA	AK053633.1	BAC35455.1	C57BL/6J
mRNA	AK054289.1	None	C57BL/6J
mRNA	AK137629.1	BAE23437.1	C57BL/6J
mRNA	AK154041.1	BAE32333.1	NOD
mRNA	AK185432.1	None
mRNA	AK192846.1	None
mRNA	AK211466.1	None
mRNA	AK211487.1	None
mRNA	AK212278.1	None
mRNA	AK212379.1	None
other-genetic	BC152908.1	AAI52909.1