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pias2 protein inhibitor of activated STAT, 2 [ Danio rerio (zebrafish) ]

Gene ID: 564149, updated on 11-Apr-2024

Summary

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Official Symbol
pias2provided by ZNC
Official Full Name
protein inhibitor of activated STAT, 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060424-1
See related
Ensembl:ENSDARG00000092979 AllianceGenome:ZFIN:ZDB-GENE-060424-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
piasx; wu:fi05f09
Summary
Predicted to enable SUMO ligase activity and transcription coregulator activity. Predicted to be involved in protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41476446..41485229)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (40876293..40885076)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene AT rich interactive domain 3C (BRIGHT-like) Neighboring gene uncharacterized LOC103911098 Neighboring gene uncharacterized LOC101882386 Neighboring gene eukaryotic translation elongation factor 2, like 2 Neighboring gene FA complementation group G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. Xiong R, et al. J Immunol, 2012 Mar 15. PMID 22345667
  2. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Meng ZZ, et al. Nat Commun, 2017 Mar 3. PMID 28256502, Free PMC Article
  3. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
  4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS2
NP_001313410.1
XP_005165453.1
XP_005165456.1
XP_005165457.1
XP_005165458.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326481.1 → NP_001313410.1  E3 SUMO-protein ligase PIAS2

    Status: VALIDATED

    Source sequence(s)
    CR318632
    UniProtKB/TrEMBL
    A0A8M1P805, A2CE48
    Related
    ENSDARP00000122573.1, ENSDART00000142538.3
    Conserved Domains (3) summary
    smart00513
    Location:11 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:341 → 389
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:143 → 281
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    41476446..41485229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165400.4 → XP_005165457.1  E3 SUMO-protein ligase PIAS2 isoform X2

    See identical proteins and their annotated locations for XP_005165457.1

    UniProtKB/TrEMBL
    A0A8M2BCQ4, X1WFJ1
    Related
    ENSDARP00000128995.2, ENSDART00000153567.3
    Conserved Domains (3) summary
    smart00513
    Location:2 → 27
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 380
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:134 → 272
    PINIT; PINIT domain

  2. XM_005165396.3 → XP_005165453.1  E3 SUMO-protein ligase PIAS2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCP8
    Conserved Domains (3) summary
    smart00513
    Location:11 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:341 → 389
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:143 → 281
    PINIT; PINIT domain

  3. XM_005165399.4 → XP_005165456.1  E3 SUMO-protein ligase PIAS2 isoform X2

    See identical proteins and their annotated locations for XP_005165456.1

    UniProtKB/TrEMBL
    A0A8M2BCQ4, X1WFJ1
    Conserved Domains (3) summary
    smart00513
    Location:2 → 27
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 380
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:134 → 272
    PINIT; PINIT domain

  4. XM_005165401.4 → XP_005165458.1  E3 SUMO-protein ligase PIAS2 isoform X2

    See identical proteins and their annotated locations for XP_005165458.1

    UniProtKB/TrEMBL
    A0A8M2BCQ4, X1WFJ1
    Conserved Domains (3) summary
    smart00513
    Location:2 → 27
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 380
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:134 → 272
    PINIT; PINIT domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395242.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    244668..253464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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