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Trip4 thyroid hormone receptor interactor 4 [ Mus musculus (house mouse) ]

Gene ID: 56404, updated on 7-Feb-2016
Official Symbol
Trip4provided by MGI
Official Full Name
thyroid hormone receptor interactor 4provided by MGI
Primary source
MGI:MGI:1928469
See related
Ensembl:ENSMUSG00000032386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asc1; ASC-1; BB191711; 4930558E03Rik
Orthologs
See Trip4 in Epigenomics, MapViewer
Location:
9; 9 D
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (65828926..65908809, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (65676733..65756601, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene zinc finger protein 609 Neighboring gene predicted gene, 30089 Neighboring gene predicted gene, 30314 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 2810417H13 gene Neighboring gene casein kinase 1, gamma 1 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
ligand-dependent nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
activating signal cointegrator 1
Names
TR-interacting protein 4
TRIP-4
thyroid receptor-interacting protein 4
transcription coactivator Asc1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170907.1NP_001164378.1  activating signal cointegrator 1 isoform 2

    See identical proteins and their annotated locations for NP_001164378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC151906, AK039024, AW121332, BB617447
    Consensus CDS
    CCDS52838.1
    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434525
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  2. NM_019797.4NP_062771.2  activating signal cointegrator 1 isoform 1

    See identical proteins and their annotated locations for NP_062771.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also referred to as the testis specific form) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC151906, AW121332
    Consensus CDS
    CCDS23298.1
    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    65828926..65908809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511299.2XP_006511362.1  

    See identical proteins and their annotated locations for XP_006511362.1

    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  2. XM_006511298.2XP_006511361.1  

    See identical proteins and their annotated locations for XP_006511361.1

    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  3. XM_006511296.2XP_006511359.1  

    See identical proteins and their annotated locations for XP_006511359.1

    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  4. XM_011242778.1XP_011241080.1  

    See identical proteins and their annotated locations for XP_011241080.1

    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  5. XM_011242779.1XP_011241081.1  

    See identical proteins and their annotated locations for XP_011241081.1

    UniProtKB/Swiss-Prot
    Q9QXN3
    Related
    ENSMUSP00000137304, ENSMUST00000179395
    Conserved Domains (3) summary
    cd06554
    Location:434525
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  6. XM_011242777.1XP_011241079.1  

    See identical proteins and their annotated locations for XP_011241079.1

    UniProtKB/Swiss-Prot
    Q9QXN3
    Conserved Domains (3) summary
    cd06554
    Location:434547
    ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
  7. XM_011242780.1XP_011241082.1  

    Conserved Domains (3) summary
    pfam06221
    Location:167218
    zf-C2HC5; Putative zinc finger motif, C2HC5-type
    cl00829
    Location:766
    UxaC; Glucuronate isomerase
    cl01020
    Location:434452
    ASCH; ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, ...

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    63066228..63147772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)