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Pdlim5 PDZ and LIM domain 5 [ Mus musculus (house mouse) ]

Gene ID: 56376, updated on 8-May-2016
Official Symbol
Pdlim5provided by MGI
Official Full Name
PDZ and LIM domain 5provided by MGI
Primary source
MGI:MGI:1927489
See related
Ensembl:ENSMUSG00000028273 Vega:OTTMUSG00000053833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Enh; LIM; Enh1; Enh2; Enh3; C87059; AI987914; 1110001A05Rik
Orthologs
Location:
3; 3 H3
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (142239585..142395696, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (141903568..142058630, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein receptor, type 1B Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 3 Neighboring gene predicted gene, 33189 Neighboring gene guanylate binding protein 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding ISO
Inferred from Sequence Orthology
more info
 
actinin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
PDZ and LIM domain protein 5
Names
enigma homolog
enigma-like PDZ and LIM domains protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190852.1NP_001177781.1  PDZ and LIM domain protein 5 isoform ENH1e

    See identical proteins and their annotated locations for NP_001177781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and it encodes the longest protein (isoform ENH1e).
    Source sequence(s)
    AC139128, AC158581, AK147999, BY227455, DV551664
    Consensus CDS
    CCDS80038.1
    UniProtKB/Swiss-Prot
    Q8CI51
    UniProtKB/TrEMBL
    D9J302
    Related
    ENSMUSP00000142737, OTTMUSP00000071125, ENSMUST00000195975, OTTMUST00000133974
    Conserved Domains (3) summary
    cd09453
    Location:438489
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:556610
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001190853.1NP_001177782.1  PDZ and LIM domain protein 5 isoform ENH4

    See identical proteins and their annotated locations for NP_001177782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 4. The resulting protein (isoform ENH4) has a shorter and distinct C-terminus when compared to isoform ENH1e.
    Source sequence(s)
    AC139128, AC158581, AK009464
    Consensus CDS
    CCDS57258.1
    UniProtKB/TrEMBL
    Q9CRA2
    Related
    ENSMUSP00000087595, OTTMUSP00000071144, ENSMUST00000090134, OTTMUST00000134007
    Conserved Domains (1) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001190854.1NP_001177783.1  PDZ and LIM domain protein 5 isoform ENH1b

    See identical proteins and their annotated locations for NP_001177783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons, compared to variant 4. The resulting protein (isoform ENH1b) is shorter, compared to isoform ENH1e.
    Source sequence(s)
    AC139128, AC158581, AK147999, BY227455, DV551664
    Consensus CDS
    CCDS80035.1
    UniProtKB/Swiss-Prot
    Q8CI51
    UniProtKB/TrEMBL
    D9J2Z9
    Related
    ENSMUSP00000142899, OTTMUSP00000071128, ENSMUST00000198381, OTTMUST00000133977
    Conserved Domains (4) summary
    PHA03381
    Location:136323
    PHA03381; tegument protein VP22; Provisional
    cd09453
    Location:306357
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:424478
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. NM_001190855.1NP_001177784.1  PDZ and LIM domain protein 5 isoform ENH1c

    See identical proteins and their annotated locations for NP_001177784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate exons, compared to variant 4. The resulting protein (isoform ENH1c) is shorter when it is compared to isoform ENH1e.
    Source sequence(s)
    AC139128, AC158581, AK147999, BY227455, DV551664
    Consensus CDS
    CCDS80036.1
    UniProtKB/Swiss-Prot
    Q8CI51
    UniProtKB/TrEMBL
    D9J300
    Related
    ENSMUSP00000143343, OTTMUSP00000071126, ENSMUST00000200043, OTTMUST00000133975
    Conserved Domains (3) summary
    cd09453
    Location:350401
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:468522
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. NM_001190856.1NP_001177785.1  PDZ and LIM domain protein 5 isoform ENH1d

    See identical proteins and their annotated locations for NP_001177785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon, compared to variant 4. The resulting protein (isoform ENH1d) is shorter when it is compared to isoform ENH1e.
    Source sequence(s)
    AC139128, AC158581, AK147999, BY227455, DV551664
    Consensus CDS
    CCDS80037.1
    UniProtKB/Swiss-Prot
    Q8CI51
    UniProtKB/TrEMBL
    D9J301
    Related
    ENSMUSP00000142460, OTTMUSP00000071127, ENSMUST00000196220, OTTMUST00000133976
    Conserved Domains (3) summary
    cd09453
    Location:398449
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:516570
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  6. NM_001190857.1NP_001177786.1  PDZ and LIM domain protein 5 isoform ENH3a

    See identical proteins and their annotated locations for NP_001177786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple differences in the 3' end, compared to variant 4. The resulting protein (isoform ENH3a) has a shorter and distinct C-terminus when compared to isoform ENH1e.
    Source sequence(s)
    AA061806, AC139128, BY227455, CA534475, CB597177
    Consensus CDS
    CCDS80039.1
    UniProtKB/TrEMBL
    D9J303
    Related
    ENSMUSP00000132647, OTTMUSP00000071131, ENSMUST00000168967, OTTMUST00000133980
    Conserved Domains (1) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. NM_019808.3NP_062782.2  PDZ and LIM domain protein 5 isoform ENH1

    See identical proteins and their annotated locations for NP_062782.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses a different splice site and lacks alternate segments, compared to variant 4. The resulting protein (isoform ENH1) is shorter when it is compared to isoform ENH1e. This isoform has also been called ENH1/1a.
    Source sequence(s)
    AC139128, AC158581, AK147999, BY227455, DV551664
    Consensus CDS
    CCDS17875.1
    UniProtKB/Swiss-Prot
    Q8CI51
    Related
    ENSMUSP00000029941, OTTMUSP00000071124, ENSMUST00000029941, OTTMUST00000133973
    Conserved Domains (3) summary
    cd09453
    Location:415466
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:533587
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  8. NM_019809.3NP_062783.2  PDZ and LIM domain protein 5 isoform ENH2

    See identical proteins and their annotated locations for NP_062783.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site and has multiple differences in the 3' end, compared to variant 4. The resulting protein (isoform ENH2) is shorter and has a distinct C-terminus when it is compared to isoform ENH1e.
    Source sequence(s)
    AC139128, AC158581, AI391027, AK009464, BY227455, BY741234
    Consensus CDS
    CCDS17876.1
    UniProtKB/TrEMBL
    Q9CRA2
    Related
    ENSMUSP00000143098, OTTMUSP00000071132, ENSMUST00000196908, OTTMUST00000133981
    Conserved Domains (1) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. NM_022554.3NP_072048.2  PDZ and LIM domain protein 5 isoform ENH3b

    See identical proteins and their annotated locations for NP_072048.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 4. The resulting protein (isoform ENH3b) has a shorter and distinct C-terminus when it is compared to isoform ENH1e. The encoded isoform was previously known as ENH3b.
    Source sequence(s)
    AA512794, AC139128, BY227455, CA534475
    Consensus CDS
    CCDS38656.1
    UniProtKB/TrEMBL
    E9Q8P5
    Related
    ENSMUSP00000128752, OTTMUSP00000071143, ENSMUST00000170361, OTTMUST00000134006
    Conserved Domains (1) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    142239585..142395696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240170.1XP_011238472.1  

    Conserved Domains (2) summary
    cd09453
    Location:436487
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cl02475
    Location:554608
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_006501748.1XP_006501811.1  

    Conserved Domains (4) summary
    PHA03381
    Location:132329
    PHA03381; tegument protein VP22; Provisional
    cd09453
    Location:312363
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:430484
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_006501745.1XP_006501808.1  

    Conserved Domains (3) summary
    cd09453
    Location:444495
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:562616
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. XM_006501744.1XP_006501807.1  

    Conserved Domains (4) summary
    cd09453
    Location:449500
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:508559
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:567621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. XM_006501740.1XP_006501803.1  

    Conserved Domains (4) summary
    cd09453
    Location:547598
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:606657
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:665719
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_006501739.1XP_006501802.1  

    Conserved Domains (4) summary
    cd09453
    Location:553604
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:612663
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:671725
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_006501746.1XP_006501809.1  

    Conserved Domains (4) summary
    cd09453
    Location:426477
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:544598
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl02475
    Location:485536
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  8. XM_006501743.1XP_006501806.1  

    Conserved Domains (4) summary
    cd09453
    Location:474525
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:533584
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:592646
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_006501741.1XP_006501804.1  

    Conserved Domains (5) summary
    cd09453
    Location:518569
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:577628
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:636690
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    PRK00708
    Location:65171
    PRK00708; sec-independent translocase; Provisional
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. XM_006501742.1XP_006501805.1  

    Conserved Domains (4) summary
    cd09453
    Location:514565
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:573624
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:632686
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_006501738.1XP_006501801.1  

    Conserved Domains (4) summary
    cd09453
    Location:558609
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09457
    Location:617668
    LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:676730
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_006501751.1XP_006501814.1  

    See identical proteins and their annotated locations for XP_006501814.1

    UniProtKB/TrEMBL
    D9J303
    Related
    ENSMUSP00000059267, ENSMUST00000058626
    Conserved Domains (1) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. XM_006501750.1XP_006501813.1  

    See identical proteins and their annotated locations for XP_006501813.1

    UniProtKB/TrEMBL
    E9Q8P5
    Conserved Domains (1) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    148659382..148819783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)