Rybp RING1 and YY1 binding protein [Mus musculus] - Gene

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Summary

Official Symbol: Rybpprovided by MGI
Official Full Name: RING1 and YY1 binding proteinprovided by MGI
Primary source: MGI:1929059
See related: Ensembl:ENSMUSG00000072872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DEDAF; YEAF1; 2410018J24Rik; MGC62213

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Genomic context

Location :: 6 E1; 6

Sequence :: Chromosome: 6; NC_000072.6 (100228565..100287358, complement)

See Rybp in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rybp efficiently represses endogenous retroviruses (murine endogenous retrovirus [MuERV] class) and preimplantation (including zygotic genome activation stage)- and germ line-specific genes.
Title: RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.
RYBP-PRC1 is recruited to target loci in mESCs and is also involved in Xist RNA-mediated silencing, the latter suggesting a wider role in Polycomb silencing.
Title: RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.
These findings suggest that Rybp and Hippi may functionally interact in the apoptotic processes that accompany normal murine neural development.
Title: Rybp interacts with Hippi and enhances Hippi-mediated apoptosis.
Rybp/DEDAF is required for early postimplantation and for central nervous system development
Title: Rybp/DEDAF is required for early postimplantation and for central nervous system development.
multiple functions for Rybp in regulating mouse retinal and lens development are mediated by genetic, epigenetic and physical interactions between these genes and proteins
Title: Rybp, a polycomb complex-associated protein, is required for mouse eye development.
The Rybp interacting PcG protein Ring1B, a known ubiquitin E3 ligase, promotes Rybp ubiquitination; one target of Rybp's ubiquitin binding domain appears to be ubiquitinated histone H2A
Title: The Polycomb-associated protein Rybp is a ubiquitin binding protein.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Reporter) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:207918	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:207918	BioGRID:202894	Ring1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:207918	BioGRID:202919	Rnf2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:207918	BioGRID:219895	Tfcp2l1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:207918	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
histone H2A monoubiquitination	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: RING1 and YY1-binding protein

Names: RING1 and YY1-binding protein; DED-associated factor; Ring1 interactor Rybp; death effector domain-associated factor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019743.3 → NP_062717.2 RING1 and YY1-binding protein

Status: PROVISIONAL

Source sequence(s)

AC158655

Consensus CDS

CCDS39579.1

UniProtKB/Swiss-Prot

Q8CCI5

Related

ENSMUSP00000098677, ENSMUST00000101118

Conserved Domains (1) summary

cl02656
Location:23 – 45
Blast Score: 97

zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38 C57BL/6J

Range

100228565..100287358, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

102093266..102151363, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC158655.4 (7439..66233)	None
genomic	CH466523.1	EDK99370.1	mixed
mRNA	AF101779.1	AAD42945.1	C57BL/10
mRNA	AK010548.1	None	C57BL/6J
mRNA	AK033024.1	BAC28131.1	C57BL/6J
mRNA	BC053016.1	AAH53016.1	C57BL/6
mRNA	BC080287.1	AAH80287.1	C57BL/6
mRNA	BC138324.1	AAI38325.1
mRNA	BC138325.1	AAI38326.1