Txnip thioredoxin interacting protein [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Txnipprovided by MGI
Official Full Name: thioredoxin interacting proteinprovided by MGI
Primary source: MGI:1889549
See related: Ensembl:ENSMUSG00000038393; Vega:OTTMUSG00000021271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik

Genomic context

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Location :: 3 F2.2; 3 41.93 cM

Sequence :: Chromosome: 3; NC_000069.6 (96557957..96561857)

See Txnip in Epigenomics, MapViewer

Chromosome 3 - NC_000069.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that thioredoxin-interacting protein (TxNIP) is a critical component of the high glucos-reactive oxygen species signaling pathway, required for the induction of mitochondrial and total cell ROS and the NADPH oxidase isoform, Nox4.
Title: Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells.
Upregulation of Trx1 by Na2S therapy in the setting of heart failure sets into motion events which ultimately leads to the attenuationof left-ventricular remodeling.
Title: Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.
VDUP1-deficient mice wereresistant to P. aeruginosa-induced bacteremic shock. It promoted neutrophil recruitment into the peritoneal cavity & impeded the phagocytosis of non-opsonized P. aeruginosa by the PI 3-kinase pathway in macrophages.
Title: VDUP1 exacerbates bacteremic shock in mice infected with Pseudomonas aeruginosa.
Nrf2 is a key gatekeeper of Txnip transcription, suppressing both its basal expression and MondoA-driven induction to control the thioredoxin redox signaling in diabetes.
Title: Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein.
Txnip expression is induced in neurons after oxidative or glucose stress under either ischemia or ischemic reperfusion; Txnip is proapoptotic under these conditions.
Title: Induction of thioredoxin-interacting protein is mediated by oxidative stress, calcium, and glucose after brain injury in mice.
TXNIP is a critical signaling node that links endoplasmic reticulum stress and inflammation.
Title: Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
TXNIP is a critical node in the unfolded protein response; elevated levels activate the NLRP3 inflammasome causing procaspase-1 cleavage and interleukin 1beta secretion.
Title: IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
TBP-2 deficiency enhances TGF-beta signaling and promotes TGF-beta-induced epithelial-mesenchymal transition.
Title: Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition.
these results identify a critical role for TXNIP in Agrp neurons in mediating diet-induced obesity through the regulation of energy expenditure and adipose tissue metabolism, independently of food intake.
Title: TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity.
Chronic intermittent hypoxia induces a thioredoxin mechanism change in a gender-specific fashion in mice.
Title: Chronic intermittent hypoxia induces thioredoxin system changes in a gender-specific fashion in mice.

Submit: New GeneRIF Correction See all (54)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (4) 1 citation
Spontaneous (1) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:207912	BioGRID:113146	TXN		BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inflammasomes, organism-specific biosystem (from REACTOME)
Inflammasomes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
The NLRP3 inflammasome, organism-specific biosystem (from REACTOME)
The NLRP3 inflammasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH98174 (e-PCR)
- UniSTS:85284

AA682105 (e-PCR)
- UniSTS:159156

Homology

Homologs of the Txnip gene: The Txnip gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cellular response to tumor cell	ISO Inferred from Sequence Orthology more info
keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell division	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin-interacting protein

Names: thioredoxin-interacting protein; hyperlipidemia 1; thioredoxin binding protein-2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009935.2 → NP_001009935.1 thioredoxin-interacting protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC122037

Consensus CDS

CCDS38555.1

UniProtKB/Swiss-Prot

Q8BG60

Related

ENSMUSP00000102710, OTTMUSP00000023522, ENSMUST00000074519, OTTMUST00000050413

Conserved Domains (2) summary

smart01017
Location:176 – 297
Blast Score: 197

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:10 – 153
Blast Score: 232

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
NM_023719.2 → NP_076208.2 thioredoxin-interacting protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AK089403, AK171456

Consensus CDS

CCDS17640.1

UniProtKB/Swiss-Prot

Q8BG60

Related

ENSMUSP00000041467, OTTMUSP00000023523, ENSMUST00000049093, OTTMUST00000050414

Conserved Domains (2) summary

smart01017
Location:175 – 296
Blast Score: 196

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:10 – 152
Blast Score: 238

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000069.6 Reference GRCm38.p1 C57BL/6J

Range

96557957..96561857

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000025.1 Alternate Mm_Celera

Range

97964967..97968875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01029317.1 (3197..7105)	None
genomic	AC122037.2 (88237..92147)	None
genomic	AF282825.1	AAG32665.1	C57BL/6
genomic	AF449447.1 (32189..36109)	None	C3H
genomic	CH466620.1	EDL38892.1	mixed
		EDL38893.1	mixed
mRNA	AF173681.1	AAD48499.1
mRNA	AF282826.1	AAG32666.1	C57BL/6
mRNA	AK004653.2	BAB23444.1	C57BL/6J
mRNA	AK082476.1	BAC38504.1	C57BL/6J
mRNA	AK088870.1	BAC40625.1	NOD
mRNA	AK089304.1	BAC40834.1	C57BL/6J
mRNA	AK089351.1	BAC40850.1	C57BL/6J
mRNA	AK089403.1	BAC40868.1	C57BL/6J
mRNA	AK155517.1	BAE33304.1	NOD
mRNA	AK155649.1	None	C57BL/6J
mRNA	AK171205.1	BAE42311.1	NOD
mRNA	AK171312.1	BAE42386.1	NOD
mRNA	AK171425.1	BAE42444.1	C57BL/6J
mRNA	AK171456.1	BAE42465.1	C57BL/6J
mRNA	AK171464.1	BAE42470.1	C57BL/6J
mRNA	AK171527.1	BAE42508.1	C57BL/6J
mRNA	AK181626.1	None
mRNA	AK187108.1	None
mRNA	AK192038.1	None
mRNA	AK200630.1	None
mRNA	AK208315.1	None
mRNA	AK214578.1	None
mRNA	AK217452.1	None
mRNA	AK219290.1	None
mRNA	BC011212.1	AAH11212.1	FVB/N
mRNA	BC031850.1	AAH31850.1	CZECHII