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Dbn1 drebrin 1 [ Mus musculus (house mouse) ]

Gene ID: 56320, updated on 10-May-2016
Official Symbol
Dbn1provided by MGI
Official Full Name
drebrin 1provided by MGI
Primary source
MGI:MGI:1931838
See related
Ensembl:ENSMUSG00000034675 Vega:OTTMUSG00000017050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
13 B1; 13 30.06 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (55473428..55488163, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55574789..55589437, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic) Neighboring gene microRNA 6944 Neighboring gene PDZ and LIM domain 7 Neighboring gene microRNA 6945 Neighboring gene docking protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
profilin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
cell communication by chemical coupling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell communication by electrical coupling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of actin-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic density protein 95 clustering ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
axonal spine ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendritic filopodium ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
filopodium ISO
Inferred from Sequence Orthology
more info
 
gap junction IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron spine ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
drebrin
Names
developmentally-regulated brain protein
drebrin A
drebrin E2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177371.1NP_001170842.1  drebrin isoform 1

    See identical proteins and their annotated locations for NP_001170842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS49274.1
    UniProtKB/Swiss-Prot
    Q9QXS6
    Related
    ENSMUSP00000021950, OTTMUSP00000018533, ENSMUST00000021950, OTTMUST00000041296
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  2. NM_001177372.1NP_001170843.1  drebrin isoform 2

    See identical proteins and their annotated locations for NP_001170843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) differs in two regions, compared to isoform 1.
    Source sequence(s)
    AK132060, BY255065, CT009762
    Consensus CDS
    CCDS49273.1
    UniProtKB/Swiss-Prot
    Q9QXS6
    UniProtKB/TrEMBL
    A0A0R4J1E3
    Related
    ENSMUSP00000105547, OTTMUSP00000062076, ENSMUST00000109921, OTTMUST00000111071
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  3. NM_019813.4NP_062787.2  drebrin isoform 3

    See identical proteins and their annotated locations for NP_062787.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) lacks an alternate segment, compared to isoform 1.
    Source sequence(s)
    AK162697, BY255065, CT009762
    Consensus CDS
    CCDS36677.1
    UniProtKB/Swiss-Prot
    Q9QXS6
    UniProtKB/TrEMBL
    Q3TRK3
    Related
    ENSMUSP00000105549, OTTMUSP00000018532, ENSMUST00000109923, OTTMUST00000041295
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    55473428..55488163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517305.2XP_006517368.1  

    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    56527471..56542117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)