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PARD3 par-3 family cell polarity regulator [ Homo sapiens (human) ]

Gene ID: 56288, updated on 5-Jul-2015
Official Symbol
PARD3provided by HGNC
Official Full Name
par-3 family cell polarity regulatorprovided by HGNC
Primary source
HGNC:HGNC:16051
See related
Ensembl:ENSG00000148498; HPRD:05994; MIM:606745; Vega:OTTHUMG00000017948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Baz; ASIP; PAR3; PARD-3; PARD3A; SE2-5T2; PPP1R118; SE2-5L16; SE2-5LT1; PAR3alpha
Summary
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Orthologs
See PARD3 in Epigenomics, MapViewer
Location:
10p11.21
Exon count:
30
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (34109560..34815325, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (34398488..35104253, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 838 Neighboring gene ribosomal protein L23 pseudogene 11 Neighboring gene transfer RNA-Leu (CAA) 7-1 Neighboring gene transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) pseudogene 4 Neighboring gene ribosomal protein L37 pseudogene 18 Neighboring gene ribosomal protein S12 pseudogene 16 Neighboring gene PARD3 antisense RNA 1 Neighboring gene synovial sarcoma translocation gene on chromosome 18-like 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
NHGRI GWA Catalog
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
NHGRI GWA Catalog
Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.
NHGRI GWA Catalog
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
    Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemIn normal cells and in the early stages of cancer development, signaling by TGF-beta plays a tumor suppressive role, as SMAD2/3:SMAD4-mediated transcription inhibits cell division by downregulating M...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction interactions, organism-specific biosystem (from REACTOME)
    Tight junction interactions, organism-specific biosystemTight junctions (TJs) are the most apical component of the epithelial junctional complex forming a belt-like structure at the cellular junction. When visualized by freeze-fracture electron microscopy...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ21015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apical constriction IEA
Inferred from Electronic Annotation
more info
 
asymmetric cell division TAS
Traceable Author Statement
more info
PubMed 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
bicellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
bicellular tight junction assembly TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell junction assembly TAS
Traceable Author Statement
more info
 
cell-cell junction organization TAS
Traceable Author Statement
more info
 
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
establishment of epithelial cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex assembly TAS
Traceable Author Statement
more info
PubMed 
protein kinase C-activating G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin filament-based process IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular localization IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
wound healing, spreading of cells IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cell junction TAS
Traceable Author Statement
more info
 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
internode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein complex IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
partitioning defective 3 homolog
Names
CTCL tumor antigen se2-5
PAR3-alpha
atypical PKC isotype-specific interacting protein
atypical PKC isotype-specific-interacting protein
bazooka
par-3 family cell polarity regulator alpha
par-3 partitioning defective 3 homolog
protein phosphatase 1, regulatory subunit 118

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184785.1NP_001171714.1  partitioning defective 3 homolog isoform 2

    See identical proteins and their annotated locations for NP_001171714.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. This variant has also been called the 'long variant' and 'variant b'.
    Source sequence(s)
    AF196185, AK024668, AL160409, AL450337, AW242451
    Consensus CDS
    CCDS53515.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000363920, OTTHUMP00000019429, ENST00000374788, OTTHUMT00000047528
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001184786.1NP_001171715.1  partitioning defective 3 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate, in-frame segment and uses a different splice site, in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK025892, AL160409, AL450337, AW242451, BC071566
    Consensus CDS
    CCDS53511.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000443147, ENST00000545693
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001184787.1NP_001171716.1  partitioning defective 3 homolog isoform 4

    See identical proteins and their annotated locations for NP_001171716.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate, in-frame segment in the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. This variant has also been called 'variant d'.
    Source sequence(s)
    AF332592, AF467004, AL160409, AL450337, AW242451
    Consensus CDS
    CCDS53514.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000340591, OTTHUMP00000019430, ENST00000346874, OTTHUMT00000047529
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. NM_001184788.1NP_001171717.1  partitioning defective 3 homolog isoform 5

    See identical proteins and their annotated locations for NP_001171717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate, in-frame segment and uses two different splice sites, in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1. This variant has also been called 'variant f'.
    Source sequence(s)
    AF332592, AF467006, AL160409, AL450337, AW242451
    Consensus CDS
    CCDS53512.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000311986, OTTHUMP00000019432, ENST00000350537, OTTHUMT00000047531
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. NM_001184789.1NP_001171718.1  partitioning defective 3 homolog isoform 6

    See identical proteins and their annotated locations for NP_001171718.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate, in-frame segments and uses two different splice sites, in the coding region, compared to variant 1. The resulting protein (isoform 6) is shorter when it is compared to isoform 1. This variant has also been called 'long variant b'.
    Source sequence(s)
    AF332593, AF467006, AK024668, AL160409, AL450337, AW242451
    UniProtKB/Swiss-Prot
    Q8TEW0
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. NM_001184790.1NP_001171719.1  partitioning defective 3 homolog isoform 7

    See identical proteins and their annotated locations for NP_001171719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate, in-frame segments and uses two different splice sites, in the coding region, compared to variant 1. The resulting protein (isoform 7) is shorter when it is compared to isoform 1. This variant has also been called 'variant c'.
    Source sequence(s)
    AB073671, AF252293, AF467003, AL160409, AL450337, AW242451
    Consensus CDS
    CCDS53510.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000440857, ENST00000545260
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:421500
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. NM_001184791.1NP_001171720.1  partitioning defective 3 homolog isoform 8

    See identical proteins and their annotated locations for NP_001171720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks four alternate, in-frame segments and uses a different splice site, in the coding region, compared to variant 1. The resulting protein (isoform 8) is shorter when it is compared to isoform 1. This variant has also been called 'variant e'.
    Source sequence(s)
    AB073671, AF467005, AL160409, AL450337, AW242451
    Consensus CDS
    CCDS53509.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000363926, OTTHUMP00000019431, ENST00000374794, OTTHUMT00000047530
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:421500
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. NM_001184792.1NP_001171721.1  partitioning defective 3 homolog isoform 9

    See identical proteins and their annotated locations for NP_001171721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses a different splice site, lacks most of the 3' coding region, and contains a different segment for its 3' end, compared to variant 1. The resulting protein (isoform 9) is shorter and has a distinct C-terminus when it is compared to isoform 1. This variant has also been called the 'short variant'.
    Source sequence(s)
    AF196186, AL450337, BE464617, BM796605
    Consensus CDS
    CCDS53516.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000341844, ENST00000340077
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. NM_001184793.1NP_001171722.1  partitioning defective 3 homolog isoform 10

    See identical proteins and their annotated locations for NP_001171722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses three different splice sites, lacks most of the 3' coding region, and contains a different segment for its 3' end, compared to variant 1. The resulting protein (isoform 10) is shorter and has a distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AF332592, AK024668, AK027735, AL450337, BE464617
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000363905, OTTHUMP00000019434, ENST00000374773, OTTHUMT00000047534
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. NM_001184794.1NP_001171723.1  partitioning defective 3 homolog isoform 11

    See identical proteins and their annotated locations for NP_001171723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks an alternate, in-frame, exon, uses two different splice sites, lacks most of the 3' coding region, and contains a different segment for its 3' end, compared to variant 1. The resulting protein (isoform 11) is shorter and has a distinct C-terminus when it is compared to isoform 1. This variant has also been called 'short variant b'.
    Source sequence(s)
    AF332592, AK024668, AL450337, BE464617
    Consensus CDS
    CCDS53513.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000363908, OTTHUMP00000019427, ENST00000374776, OTTHUMT00000047526
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. NM_019619.3NP_062565.2  partitioning defective 3 homolog isoform 1

    See identical proteins and their annotated locations for NP_062565.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). This variant has also been called 'variant a'.
    Source sequence(s)
    AA136967, AF467002, AL160409, AL450337, AW242451
    Consensus CDS
    CCDS7178.1
    UniProtKB/Swiss-Prot
    Q8TEW0
    Related
    ENSP00000363921, OTTHUMP00000019428, ENST00000374789, OTTHUMT00000047527
    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    34109560..34815325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519578.1XP_011517880.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:421500
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_011519577.1XP_011517879.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:532625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_011519573.1XP_011517875.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_011519572.1XP_011517874.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_011519569.1XP_011517871.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_011519580.1XP_011517882.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_011519576.1XP_011517878.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:421500
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_011519571.1XP_011517873.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_011519579.1XP_011517881.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1112
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:387466
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  10. XM_011519570.1XP_011517872.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  11. XM_011519575.1XP_011517877.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1112
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:431510
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_005252532.3XP_005252589.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:421500
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. XM_005252531.3XP_005252588.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  14. XM_005252528.3XP_005252585.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  15. XM_005252530.3XP_005252587.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  16. XM_011519574.1XP_011517876.1  

    Conserved Domains (2) summary
    pfam12053
    Location:9114
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:433512
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  17. XM_011519582.1XP_011517884.1  

    Conserved Domains (1) summary
    cd00992
    Location:195274
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  18. XM_011519581.1XP_011517883.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  19. XM_005252535.3XP_005252592.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  20. XM_005252534.3XP_005252591.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  21. XM_011519583.1XP_011517885.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  22. XM_005252536.3XP_005252593.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  23. XM_011519584.1XP_011517886.1  

    Conserved Domains (2) summary
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    34399927..35105524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)