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Mpp5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) [ Mus musculus (house mouse) ]

Gene ID: 56217, updated on 28-May-2016
Official Symbol
Mpp5provided by MGI
Official Full Name
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)provided by MGI
Primary source
MGI:MGI:1927339
See related
Ensembl:ENSMUSG00000021112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pals1; AI255216; AI644496; 3830420B02Rik
Orthologs
Location:
12; 12 C3
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (78748912..78840877)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (79849934..79941701)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene family with sequence similarity 71, member D Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
guanylate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
morphogenesis of an epithelial sheet ISO
Inferred from Sequence Orthology
more info
 
myelin assembly ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to myelin sheath abaxonal region IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lateral loop IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
MAGUK p55 subfamily member 5
Names
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5)
protein associated with Lin-7 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019579.3NP_062525.1  MAGUK p55 subfamily member 5

    See identical proteins and their annotated locations for NP_062525.1

    Status: VALIDATED

    Source sequence(s)
    AK032731, AK040265, AK133187, AW488563, BB858385, BC138624
    Consensus CDS
    CCDS26001.1
    UniProtKB/Swiss-Prot
    Q9JLB2
    UniProtKB/TrEMBL
    B2RRY4
    Related
    ENSMUSP00000080683, ENSMUST00000082024
    Conserved Domains (7) summary
    pfam09060
    Location:123171
    L27_N; L27_N
    smart00569
    Location:189237
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12036
    Location:349411
    SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)
    cd00071
    Location:481656
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:254333
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:478659
    Guanylate_kin; Guanylate kinase
    cl00638
    Location:594626
    RNA_pol_Rpb4; RNA polymerase Rpb4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    78748912..78840877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516097.2XP_006516160.1  

    See identical proteins and their annotated locations for XP_006516160.1

    UniProtKB/Swiss-Prot
    Q9JLB2
    UniProtKB/TrEMBL
    B2RRY4
    Conserved Domains (7) summary
    pfam09060
    Location:123171
    L27_N; L27_N
    smart00569
    Location:189237
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12036
    Location:349411
    SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)
    cd00071
    Location:481656
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:254333
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:478659
    Guanylate_kin; Guanylate kinase
    cl00638
    Location:594626
    RNA_pol_Rpb4; RNA polymerase Rpb4
  2. XM_006516099.2XP_006516162.1  

    Conserved Domains (5) summary
    cd12036
    Location:75137
    SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)
    cd00071
    Location:207382
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:459
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:204385
    Guanylate_kin; Guanylate kinase
    cl00638
    Location:320352
    RNA_pol_Rpb4; RNA polymerase Rpb4
  3. XM_006516098.2XP_006516161.1  

    Conserved Domains (7) summary
    pfam09060
    Location:89137
    L27_N; L27_N
    smart00569
    Location:155203
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12036
    Location:315377
    SH3_MPP5; Src Homology 3 domain of Membrane Protein, Palmitoylated 5 (or MAGUK p55 subfamily member 5)
    cd00071
    Location:447622
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:220299
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:444625
    Guanylate_kin; Guanylate kinase
    cl00638
    Location:560592
    RNA_pol_Rpb4; RNA polymerase Rpb4

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    80213557..80305293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)