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Cldn14 claudin 14 [ Mus musculus (house mouse) ]

Gene ID: 56173, updated on 8-May-2016
Official Symbol
Cldn14provided by MGI
Official Full Name
claudin 14provided by MGI
Primary source
MGI:MGI:1860425
See related
Ensembl:ENSMUSG00000047109 Vega:OTTMUSG00000019962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI851731
Summary
This gene encodes a member of the claudin family of tight junction proteins. The encoded protein is an integral membrane protein that may function in maintaining apical membrane polarization in tight junctions located between outer hair cells and supporting cells. Loss of function of this gene is associated with hearing problems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
Location:
16; 16 C3-4
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (93919031..94008837, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (93919276..94009082, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30881 Neighboring gene microrchidia 3 Neighboring gene chromatin assembly factor 1, subunit B (p60) Neighboring gene predicted gene, 31012 Neighboring gene uncharacterized LOC102633190 Neighboring gene predicted gene, 31175

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165925.1NP_001159397.1  claudin-14

    See identical proteins and their annotated locations for NP_001159397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC168220, AI851731, BX522097
    Consensus CDS
    CCDS28345.1
    UniProtKB/Swiss-Prot
    Q9Z0S3
    UniProtKB/TrEMBL
    A2RSP0
    Related
    ENSMUSP00000136156, ENSMUST00000177648
    Conserved Domains (1) summary
    cl21598
    Location:23181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  2. NM_001165926.1NP_001159398.1  claudin-14

    See identical proteins and their annotated locations for NP_001159398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC168220
    Consensus CDS
    CCDS28345.1
    UniProtKB/Swiss-Prot
    Q9Z0S3
    UniProtKB/TrEMBL
    A2RSP0
    Related
    ENSMUSP00000126455, ENSMUST00000169391
    Conserved Domains (1) summary
    cl21598
    Location:23181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  3. NM_019500.4NP_062373.3  claudin-14

    See identical proteins and their annotated locations for NP_062373.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC165961, AC168220, AI851731, BE863348
    Consensus CDS
    CCDS28345.1
    UniProtKB/Swiss-Prot
    Q9Z0S3
    UniProtKB/TrEMBL
    A2RSP0
    Related
    ENSMUSP00000062045, OTTMUSP00000021531, ENSMUST00000050962, OTTMUST00000047562
    Conserved Domains (1) summary
    cl21598
    Location:23181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    93919031..94008837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523067.2XP_006523130.1  

    See identical proteins and their annotated locations for XP_006523130.1

    UniProtKB/Swiss-Prot
    Q9Z0S3
    UniProtKB/TrEMBL
    A2RSP0
    Conserved Domains (1) summary
    cl21598
    Location:23181
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    95007775..95094719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)