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    STK31 serine/threonine kinase 31 [ Homo sapiens ]

    Gene ID: 56164, updated on 11-May-2012
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    Summary

    Official Symbol
    STK31provided by HGNC
    Official Full Name
    serine/threonine kinase 31provided by HGNC
    Primary source
    HGNC:11407
    See related
    Ensembl:ENSG00000196335; HPRD:10427; MIM:605790; Vega:OTTHUMG00000023053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDRD8; SGK396; FLJ16102
    Summary
    This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    7p15.3
    Sequence :
    Chromosome: 7; NC_000007.13 (23749838..23872127)
    See STK31 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene FCF1 small subunit (SSU) processome component homolog (S. cerevisiae) pseudogene Neighboring gene coiled-coil domain containing 126 Neighboring gene family with sequence similarity 221, member A Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3 Neighboring gene neuropeptide Y Neighboring gene membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948.

    See all (7) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121097 BioGRID:110811 NEDD4    BioGRID  PubMed Biochemical Activity 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase 31
    Names
    serine/threonine-protein kinase 31
    sugen kinase 396
    tudor domain containing 8
    serine/threonine-protein kinase NYD-SPK
    NP_001116305.1
    NP_113602.2
    NP_116562.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260504.1 → NP_001247433.1  serine/threonine-protein kinase 31 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AA315045, AC003087, AC008176, AF332194, AK131214, DA533364

    2. NM_001260505.1 → NP_001247434.1  serine/threonine-protein kinase 31 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC003087, AC008176, AK302689

    3. NM_031414.4 → NP_113602.2  serine/threonine-protein kinase 31 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC003087, BC059374, DB065148, DB086591
      Consensus CDS
      CCDS5386.1
      UniProtKB/Swiss-Prot
      Q9BXU1
      Related
      ENSP00000348132, OTTHUMP00000122442, ENST00000355870, OTTHUMT00000214036
      Conserved Domains (3) summary
      cd04508
      Location:89 – 129
      Blast Score: 155
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:31 – 147
      Blast Score: 256
      TUDOR; Tudor domain
      cl09925
      Location:799 – 922
      Blast Score: 155
      PKc_like; Protein Kinases, catalytic domain

    4. NM_032944.3 → NP_116562.2  serine/threonine-protein kinase 31 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice-site in the 5' end that results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC003087, AC008176, BC059374, DB095141
      Consensus CDS
      CCDS43556.1
      UniProtKB/Swiss-Prot
      Q9BXU1
      Related
      ENSP00000406146, ENST00000428484
      Conserved Domains (3) summary
      cd04508
      Location:66 – 106
      Blast Score: 155
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:8 – 124
      Blast Score: 256
      TUDOR; Tudor domain
      cl09925
      Location:776 – 899
      Blast Score: 154
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_048542.1 RNA Sequence

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA315045, AC003087, AC008176, AK131214, BC033018, DB089624

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      23749838..23872127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      23634624..23756828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      23801635..23923918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001122833.1: Suppressed sequence

      Description
      NM_001122833.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC003087.2 AAS07416.1
    genomic AC008176.3 (1862..89979) None
    genomic CH236948.1 EAL24249.1
      EAL24250.1
    genomic CH471073.1 EAW93805.1
      EAW93806.1
    genomic HC007316.1 CBH19463.1
    genomic HC044531.1 CBH30595.1
    mRNA AF285599.1 AAK31978.1
    mRNA AF332194.1 AAK17193.1
    mRNA AK057271.1 BAB71405.1
    mRNA AK131214.1 BAG54753.1
    mRNA AK292474.1 BAF85163.1
    mRNA AK302689.1 BAG63918.1
    mRNA BC033018.1 None
    mRNA BC036476.1 None
    mRNA BC047506.1 None
    mRNA BC059374.1 AAH59374.1
    mRNA DB065148.1 None
    mRNA DB089624.1 None
    mRNA DB095141.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q75MZ9 GenPept UniProtKB/TrEMBL:Q75MZ9
    Q96MA3 GenPept UniProtKB/TrEMBL:Q96MA3
    Q9BXU1.2 GenPept UniProtKB/Swiss-Prot:Q9BXU1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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