TEX14 testis expressed 14 [Homo sapiens] - Gene

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Summary

Official Symbol: TEX14provided by HGNC
Official Full Name: testis expressed 14provided by HGNC
Primary source: HGNC:11737
See related: Ensembl:ENSG00000121101; MIM:605792
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT113
Summary: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

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Genomic context

Location :: 17q22

Sequence :: Chromosome: 17; NC_000017.10 (56634038..56769416, complement)

See TEX14 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tex14 is an important mediator of kinetochore structure and function and the fidelity of chromosome separation.
Title: Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.
Observational study of gene-disease association. (HuGE Navigator)
Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge.
Title: TEX14 interacts with CEP55 to block cell abscission.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.
TEX14, also known as SgK307, contains a variant and probably inactive protein kinase domain and N-terminal ankyrin repeats.
Title: The protein kinase complement of the human genome.
TEX14 is specifically expressed in testis
Title: An abundance of X-linked genes expressed in spermatogonia.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: inactive serine/threonine-protein kinase TEX14

Names: inactive serine/threonine-protein kinase TEX14; sugen kinase 307; cancer/testis antigen 113; testis-expressed protein 14; testis expressed sequence 14; protein kinase-like protein SgK307; testis-expressed sequence 14 protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001201457.1 → NP_001188386.1 inactive serine/threonine-protein kinase TEX14 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).

Source sequence(s)

AI243203, AL834143, BC040526, CB044007, DB086121

Consensus CDS

CCDS56042.1

UniProtKB/Swiss-Prot

Q8IWB6

Related

ENSP00000240361, ENST00000240361

Conserved Domains (4) summary

cd00204
Location:27 – 135
Blast Score: 215

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

PTZ00440
Location:613 – 776
Blast Score: 94

PTZ00440; reticulocyte binding protein 2-like protein; Provisional

pfam12796
Location:27 – 119
Blast Score: 196

Ank_2; Ankyrin repeats (3 copies)

cl09925
Location:300 – 490
Blast Score: 227

PKc_like; Protein Kinases, catalytic domain
NM_031272.4 → NP_112562.3 inactive serine/threonine-protein kinase TEX14 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.

Source sequence(s)

AI243203, BK000998, CB044007, DB086121

Consensus CDS

CCDS32692.1

UniProtKB/Swiss-Prot

Q8IWB6

Related

ENSP00000268910, ENST00000349033

Conserved Domains (4) summary

cd00204
Location:27 – 135
Blast Score: 214

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

PTZ00440
Location:607 – 770
Blast Score: 93

PTZ00440; reticulocyte binding protein 2-like protein; Provisional

pfam12796
Location:27 – 119
Blast Score: 195

Ank_2; Ankyrin repeats (3 copies)

cl09925
Location:294 – 484
Blast Score: 227

PKc_like; Protein Kinases, catalytic domain
NM_198393.3 → NP_938207.2 inactive serine/threonine-protein kinase TEX14 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.

Source sequence(s)

AI243203, AL834143, CB044007, DB086121

Consensus CDS

CCDS32693.1

UniProtKB/Swiss-Prot

Q8IWB6

Related

ENSP00000374584, ENST00000389934

Conserved Domains (4) summary

cd00204
Location:27 – 135
Blast Score: 214

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

PTZ00440
Location:607 – 770
Blast Score: 93

PTZ00440; reticulocyte binding protein 2-like protein; Provisional

pfam12796
Location:27 – 119
Blast Score: 196

Ank_2; Ankyrin repeats (3 copies)

cl09925
Location:294 – 484
Blast Score: 227

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

56634038..56769416, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

51994365..52129914, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005666.1 (134825..158904)	None
genomic	AC011195.14 (25534..136831)	None
genomic	CH471109.2	EAW94437.1
		EAW94438.1
mRNA	AF285601.1	AAK31980.1
mRNA	AI243203.1	None
mRNA	AK125896.1	None
mRNA	AK128217.1	None
mRNA	AK308299.1	None
mRNA	AL834143.1	CAD38856.2
mRNA	BC040526.1	AAH40526.1
mRNA	BC045647.1	None
mRNA	BG718877.1	None
mRNA	BK000998.1	DAA01359.1
mRNA	CB044007.1	None
mRNA	CB050840.1	None
mRNA	DB086121.1	None
other-genetic	GQ129421.1	ACT64555.1