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sipa1l3 signal-induced proliferation-associated 1 like 3 [ Danio rerio (zebrafish) ]

Gene ID: 561005, updated on 27-Mar-2024

Summary

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Official Symbol
sipa1l3provided by ZNC
Official Full Name
signal-induced proliferation-associated 1 like 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-050420-109
See related
Ensembl:ENSDARG00000061699 AllianceGenome:ZFIN:ZDB-GENE-050420-109
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-149j18.1
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (37015267..37207574)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (37034275..37222336)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100535984 Neighboring gene mitogen-activated protein kinase kinase kinase 10 Neighboring gene glutaminyl-peptide cyclotransferase-like a Neighboring gene SIX homeobox 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Greenlees R, et al. Hum Mol Genet, 2015 Oct 15. PMID 26231217
  2. Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish. Kubra K, et al. Int J Mol Sci, 2022 Sep 3. PMID 36077499, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of epithelial cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
signal-induced proliferation-associated 1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    37015267..37207574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173672.4 → XP_005173729.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005173729.1

    UniProtKB/TrEMBL
    A0A2R8RNK4, A0A8M2BKX6
    Conserved Domains (4) summary
    cd00992
    Location:912 → 982
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam06070
    Location:1051 → 1470
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    pfam02145
    Location:584 → 765
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1432 → 1662
    SPAR_C; C-terminal domain of SPAR protein

  2. XM_005173673.4 → XP_005173730.1  signal-induced proliferation-associated 1-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKY4
    Conserved Domains (3) summary
    cd00992
    Location:912 → 982
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:584 → 765
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1432 → 1656
    SPAR_C; C-terminal domain of SPAR protein

  3. XM_021467865.1 → XP_021323540.1  signal-induced proliferation-associated 1-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8RNK4, A0A8M2BKX6
    Related
    ENSDARP00000149362.1, ENSDART00000191305.1
    Conserved Domains (4) summary
    cd00992
    Location:912 → 982
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam06070
    Location:1051 → 1470
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    pfam02145
    Location:584 → 765
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1432 → 1662
    SPAR_C; C-terminal domain of SPAR protein
Nucleotide Protein
Heading Accession and Version

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