Cxcl11 chemokine (C-X-C motif) ligand 11 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cxcl11provided by MGI
Official Full Name: chemokine (C-X-C motif) ligand 11provided by MGI
Primary source: MGI:1860203
See related: Ensembl:ENSMUSG00000060183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1

Genomic context

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Location :: 5; 5 E3

Sequence :: Chromosome: 5; NC_000071.6 (92359544..92363296, complement)

See Cxcl11 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development.
Title: Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development.
the CXCL11-heparin interaction has two different affinities for glycosaminoglycans
Title: Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans.
Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge.
Title: Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide.
I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression.
Title: A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo.
I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes.
Title: I-TAC/CXCL11 is a natural antagonist for CCR5.
CXCL11 gene induction by interferon is STAT3 dependent
Title: Identification of CXCL11 as a STAT3-dependent gene induced by IFN.
homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis
Title: Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection.

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Pathways from BioSystems

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Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

General gene information

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Markers

Scyb11 (e-PCR), detects polymorphism
- UniSTS:166289

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
chemokine activity	TAS Traceable Author Statement more info	PubMed
cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
chemotaxis	IEA Inferred from Electronic Annotation more info
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 11

Names: C-X-C motif chemokine 11; small-inducible cytokine B11; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019494.1 → NP_062367.1 C-X-C motif chemokine 11 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein. This variant, which is based on a transcript from the BALB/c mouse strain, includes a 1-nt insertion in the 5'-most exon compared to the reference genome sequence, which represents a null mutant allele (C57BL/6 strain).

Source sequence(s)

AF179872

UniProtKB/Swiss-Prot

Q9JHH5

Conserved Domains (1) summary

cd00273
Location:27 – 91
Blast Score: 165

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RNA

NR_038116.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes a 1-nt deletion in the 5'-most exon, and it represents the non-functional reference genome allele (C57BL/6 strain), compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This gene is known to be non-functional in C57BL/6 mice, supported by data in PMID:17804806.

Source sequence(s)

AC122365, AK020750

Related

ENSMUST00000077820

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

92359544..92363296, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

90503193..90506949, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01046868.1 (11332..15088)	None
genomic	AC122365.4 (107614..111347)	None
genomic	AF167354.1	AAF71824.1
genomic	CH466617.2	EDL05255.1	mixed
mRNA	AF136449.1	AAF79022.1
mRNA	AF178672.1	AAF79048.1
mRNA	AF179872.1	AAF77095.1
mRNA	AK020750.1	None	C57BL/6J
mRNA	AK040051.1	None	C57BL/6J
mRNA	AK050012.1	None	C57BL/6J
mRNA	BC025903.1	AAH25903.1	CZECHII