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Gtpbp2 GTP binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 56055, updated on 11-Apr-2024

Summary

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Official Symbol
Gtpbp2provided by MGI
Official Full Name
GTP binding protein 2provided by MGI
Primary source
MGI:MGI:1860138
See related
Ensembl:ENSMUSG00000023952 AllianceGenome:MGI:1860138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nmf205
Summary
Predicted to enable GTP binding activity; identical protein binding activity; and translation elongation factor activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Is expressed in central nervous system and eye. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 32.2), thymus adult (RPKM 27.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.89 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46470153..46480294)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46159227..46169370)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head 9 homolog (Chlamydomonas) Neighboring gene MAD2L1 binding protein Neighboring gene STARR-positive B cell enhancer ABC_E5614 Neighboring gene STARR-positive B cell enhancer ABC_E5615 Neighboring gene polymerase (DNA directed), eta (RAD 30 related) Neighboring gene exportin 5 Neighboring gene microRNA 693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation. Ishimura R, et al. Elife, 2016 Apr 16. PMID 27085088, Free PMC Article
  2. Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family. Watanabe M, et al. Gene, 2000 Oct 3. PMID 11054535
  3. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. Terrey M, et al. Elife, 2020 Nov 13. PMID 33186095, Free PMC Article
  4. RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Ishimura R, et al. Science, 2014 Jul 25. PMID 25061210, Free PMC Article
  5. Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase. Kudo H, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833435

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-aminoacyl-tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rescue of stalled ribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTP-binding protein 2
Names
GTP-binding-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145979.2 → NP_001139451.1  GTP-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001139451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC116739
    UniProtKB/Swiss-Prot
    Q3UJK4
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  2. NM_001357745.2 → NP_001344674.1  GTP-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116739
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  3. NM_001410154.1 → NP_001397083.1  GTP-binding protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116739
    UniProtKB/Swiss-Prot
    Q3UJK4, Q9EST7, Q9JIX7

  4. NM_001410155.1 → NP_001397084.1  GTP-binding protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116739

  5. NM_001410156.1 → NP_001397085.1  GTP-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116739
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  6. NM_001410157.1 → NP_001397086.1  GTP-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116739
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  7. NM_001410158.1 → NP_001397087.1  GTP-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116739
    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

  8. NM_001410159.1 → NP_001397088.1  GTP-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116739

  9. NM_001410160.1 → NP_001397089.1  GTP-binding protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116739

  10. NM_019581.4 → NP_062527.2  GTP-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_062527.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116739
    Consensus CDS
    CCDS50122.1
    UniProtKB/Swiss-Prot
    Q3UJK4, Q9EST7, Q9JIX7
    UniProtKB/TrEMBL
    E9QA45
    Related
    ENSMUSP00000024748.8, ENSMUST00000024748.14
    Conserved Domains (1) summary
    cl27768
    Location:59 → 588
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_176957.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116739

  2. NR_176958.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116739

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46470153..46480294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524651.5 → XP_006524714.1  GTP-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    E9QA45
    Conserved Domains (1) summary
    COG5258
    Location:28 → 561
    GTPBP1; GTPase [General function prediction only]

  2. XM_036160688.1 → XP_036016581.1  GTP-binding protein 2 isoform X2

    Conserved Domains (1) summary
    COG5258
    Location:1 → 500
    GTPBP1; GTPase [General function prediction only]

RNA

  1. XR_004939561.1 RNA Sequence

    Related
    ENSMUST00000169383.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UJK4.1 GenPept UniProtKB/Swiss-Prot:Q3UJK4

Gene LinkOut

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