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MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens (human) ]

Gene ID: 5602, updated on 26-Aug-2014
Official Symbol
MAPK10provided by HGNC
Official Full Name
mitogen-activated protein kinase 10provided by HGNC
Primary source
HGNC:6872
Locus tag
RP13-514E23.1
See related
Ensembl:ENSG00000109339; HPRD:04207; MIM:602897; Vega:OTTHUMG00000130604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
See MAPK10 in Epigenomics, MapViewer
Location:
4q22.1-q23
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (86012299..86453130, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (86933452..87374283, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC101929015 Neighboring gene microRNA 4451 Neighboring gene uncharacterized LOC101929064 Neighboring gene microRNA 4452 Neighboring gene protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes PubMed
Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
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  • Activation of the AP-1 family of transcription factors, organism-specific biosystem (from REACTOME)
    Activation of the AP-1 family of transcription factors, organism-specific biosystemActivator protein-1 (AP-1) is a collective term referring to a group of transcription factors that bind to promoters of target genes in a sequence-specific manner. AP-1 family consists of hetero- and...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
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  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
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  • Apoptosis, organism-specific biosystem (from WikiPathways)
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  • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation by HSP70, organism-specific biosystem
    Apoptosis Modulation by HSP70
  • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
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  • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
    CD40/CD40L signaling, organism-specific biosystem
    CD40/CD40L signaling
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
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  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
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    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
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  • Colorectal cancer, conserved biosystem (from KEGG)
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  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
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  • Dopaminergic synapse, conserved biosystem (from KEGG)
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  • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
    Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
  • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
    Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
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  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
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  • ErbB signaling pathway, conserved biosystem (from KEGG)
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  • ErbB2/ErbB3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ErbB2/ErbB3 signaling events, organism-specific biosystem
    ErbB2/ErbB3 signaling events
  • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    FAS (CD95) signaling pathway, organism-specific biosystem
    FAS (CD95) signaling pathway
  • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
    FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
  • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
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  • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
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  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
    FoxO family signaling, organism-specific biosystem
    FoxO family signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
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  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
  • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
    Glucocorticoid receptor regulatory network, organism-specific biosystem
    Glucocorticoid receptor regulatory network
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Hepatitis B, organism-specific biosystem (from KEGG)
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  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
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  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
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  • Innate Immune System, organism-specific biosystem (from REACTOME)
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  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
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  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystem (from REACTOME)
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystemC-Jun NH2 terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein kinases, that belong to mitogen activated protein kinase family (MAPKs - also known as stress-acti...
  • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
    MAP kinase activation in TLR cascade, organism-specific biosystemThe mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascad...
  • MAPK Cascade, organism-specific biosystem (from WikiPathways)
    MAPK Cascade, organism-specific biosystem
    MAPK Cascade
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
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  • MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
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  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
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  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
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  • MyD88-independent cascade, organism-specific biosystem (from REACTOME)
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  • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
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  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
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  • Nephrin/Neph1 signaling in the kidney podocyte, organism-specific biosystem (from Pathway Interaction Database)
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  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
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  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
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  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
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  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
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  • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Noncanonical Wnt signaling pathway, organism-specific biosystem
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  • Osteoclast differentiation, conserved biosystem (from KEGG)
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  • Oxidative Stress, organism-specific biosystem (from WikiPathways)
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  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
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  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
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  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
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  • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
    Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Shigellosis, organism-specific biosystem (from KEGG)
    Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12099, FLJ33785, MGC50974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
MAP kinase kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
JNK cascade TAS
Traceable Author Statement
more info
 
JUN phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
JUN phosphorylation TAS
Traceable Author Statement
more info
PubMed 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
regulation of sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
toll-like receptor 10 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 3 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR1:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
mitogen-activated protein kinase 10
Names
mitogen-activated protein kinase 10
MAPK 10
MAP kinase 10
MAP kinase p49 3F12
JNK3 alpha protein kinase
c-Jun N-terminal kinase 3
stress-activated protein kinase 1b
stress activated protein kinase beta
stress-activated protein kinase JNK3
NP_002744.1
NP_620446.1
NP_620447.1
NP_620448.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013325.1 

    Range
    5001..443008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002753.3NP_002744.1  mitogen-activated protein kinase 10 isoform 1

    See proteins identical to NP_002744.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is also know as JNK3 alpha1. It contains 5 extra nt within the coding region when compared to variant 2. The translation frame is changed, and results in an isoform (1) that contains a different C-terminus, as compared to isoform 2.
    Source sequence(s)
    AC104059, U07620
    Consensus CDS
    CCDS43247.1
    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2116
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 688
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_138980.2NP_620446.1  mitogen-activated protein kinase 10 isoform 3

    See proteins identical to NP_620446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is also known as stress activated protein kinase beta. It contains a different 5' UTR region, and has an extra segment within the coding region, when compared to variant 2. The extra segment introduces an in-frame stop codon, so translation begins downstream, resulting in an N-terminal truncated isoform (3), as compared to isoform 2.
    Source sequence(s)
    AC104059, BC022492, BC035057, BC065516, DA192997
    Consensus CDS
    CCDS3612.1
    UniProtKB/TrEMBL
    A8MWW6
    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000378598, OTTHUMP00000161179, ENST00000395169, OTTHUMT00000253054
    Conserved Domains (2) summary
    cd07850
    Location:9360
    Blast Score: 2132
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:26321
    Blast Score: 698
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. NM_138981.2NP_620447.1  mitogen-activated protein kinase 10 isoform 4

    See proteins identical to NP_620447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different 5' end region, is missing a segment, and has 5 extra nt within the coding region, when compared to variant 2. The translation begins at a downstream start codon, and results in an N-terminal truncated isoform (4) containing a different C-terminus, as compared to isoform 2.
    Source sequence(s)
    AC104059, AK057723, BC022492
    Consensus CDS
    CCDS3613.1
    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    smart00220
    Location:1214
    Blast Score: 509
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:1253
    Blast Score: 1525
    PKc_like; Protein Kinases, catalytic domain
  4. NM_138982.2NP_620448.1  mitogen-activated protein kinase 10 isoform 2

    See proteins identical to NP_620448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is also known as JNK3 alpha2. It encodes the longest isoform (2).
    Source sequence(s)
    AC104059, BC035057, BC065516, DA192997
    Consensus CDS
    CCDS34026.1
    UniProtKB/TrEMBL
    A8MWW6
    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2129
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 694
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    86012299..86453130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714267.1XP_006714330.1  

    See proteins identical to XP_006714330.1

    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2129
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 694
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_005263131.2XP_005263188.1  

    See proteins identical to XP_005263188.1

    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2134
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 697
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. XM_006714269.1XP_006714332.1  

    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2121
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 690
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_005263135.2XP_005263192.1  

    See proteins identical to XP_005263192.1

    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2116
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 688
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. XM_006714268.1XP_006714331.1  

    See proteins identical to XP_006714331.1

    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:9360
    Blast Score: 2132
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:26321
    Blast Score: 698
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  6. XM_005263129.1XP_005263186.1  

    See proteins identical to XP_005263186.1

    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2129
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 694
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  7. XM_005263130.1XP_005263187.1  

    See proteins identical to XP_005263187.1

    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    cd07850
    Location:47398
    Blast Score: 2129
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    smart00220
    Location:64359
    Blast Score: 694
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  8. XM_006714270.1XP_006714333.1  

    See proteins identical to XP_006714333.1

    UniProtKB/TrEMBL
    Q499Y8
    Conserved Domains (2) summary
    smart00220
    Location:1214
    Blast Score: 519
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:1253
    Blast Score: 1545
    PKc_like; Protein Kinases, catalytic domain
  9. XM_005263136.1XP_005263193.1  

    See proteins identical to XP_005263193.1

    UniProtKB/TrEMBL
    A8MWW6
    Conserved Domains (2) summary
    smart00220
    Location:1214
    Blast Score: 516
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:1253
    Blast Score: 1540
    PKc_like; Protein Kinases, catalytic domain
  10. XM_005263138.1XP_005263195.1  

    Conserved Domains (1) summary
    cl09925
    Location:1153
    Blast Score: 870
    PKc_like; Protein Kinases, catalytic domain
  11. XM_006714272.1XP_006714335.1  

    See proteins identical to XP_006714335.1

    Conserved Domains (2) summary
    smart00220
    Location:64240
    Blast Score: 497
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:47243
    Blast Score: 1251
    PKc_like; Protein Kinases, catalytic domain
  12. XM_006714271.1XP_006714334.1  

    See proteins identical to XP_006714334.1

    Conserved Domains (2) summary
    smart00220
    Location:64240
    Blast Score: 497
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:47243
    Blast Score: 1251
    PKc_like; Protein Kinases, catalytic domain

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    82680152..83118708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    86912970..87350773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)