Cxcl13 chemokine (C-X-C motif) ligand 13 [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Cxcl13provided by MGI
Official Full Name: chemokine (C-X-C motif) ligand 13provided by MGI
Primary source: MGI:1888499
See related: Ensembl:ENSMUSG00000023078
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik

Genomic context

Go to the top of the page Help

Location :: 5 E3; 5

Sequence :: Chromosome: 5; NC_000071.6 (95956939..95961068)

See Cxcl13 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection.
Title: Interruption of CXCL13-CXCR5 axis increases upper genital tract pathology and activation of NKT cells following chlamydial genital infection.
Data show that CXCL13/CXCR5 facilitated antigen encounter and BCR signaling by promoting membrane ruffling and LFA-1-supported adhesion require a functional actin cytoskeleton and the activity of the motor protein non-muscle myosin II (NM-II).
Title: CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.
LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR.
Title: LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR.
found enhanced plasma levels of CXCL13 in lupus-prone MRL/lpr and NZB/W-F1 mice
Title: The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis.
Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues
Title: Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues.
Disease-associated B lymphocyte selection into islets occurs despite CXCL13 blockade- induced disruption of their structural organization; loss of B cell organization in islets do not provide disease protection.
Title: CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice.
elevated expression and different distribution in the aged spleen
Title: Migration of immature and mature B cells in the aged microenvironment.
New putative control elements in the promoter OF CXCL13 chemokine gene, a target of alternative NF-kappaB pathway
Title: [New putative control elements in the promoter OF CXCL13 chemokine gene, a target of alternative NF-kappaB pathway].
CXCL13 is essential for the spatial arrangement of lymphocytes within granulomas, optimal activation of phagocytes, and subsequent control of mycobacterial growth.
Title: In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity.
cigarette smoke induces pulmonary expression of lymphoid chemokines CXCL13 and CCL19 in a LTalphabeta-LTbetaR-dependent fashion
Title: Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis.

Submit: New GeneRIF Correction See all (29)

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation
Targeted (Reporter) (1) 1 citation

Pathways from BioSystems

Go to the top of the page Help

Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Markers

PMC152071P3 (e-PCR)
- UniSTS:271202

BB222854 (e-PCR)
- UniSTS:207827

PMC27130P1 (e-PCR)
- UniSTS:272375

Homology

Homologs of the Cxcl13 gene: The Cxcl13 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
CCR10 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
CXCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
CXCR5 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
CXCR5 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
chemokine activity	IDA Inferred from Direct Assay more info	PubMed
chemokine activity	ISO Inferred from Sequence Orthology more info
cytokine activity	IEA Inferred from Electronic Annotation more info
fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
heparin binding	ISO Inferred from Sequence Orthology more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
receptor agonist activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
B cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
B cell chemotaxis	ISO Inferred from Sequence Orthology more info
B cell chemotaxis across high endothelial venule	IDA Inferred from Direct Assay more info	PubMed
activation of Rap GTPase activity	IDA Inferred from Direct Assay more info	PubMed
cell-cell signaling	ISO Inferred from Sequence Orthology more info
chemokine-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
chemotaxis	IEA Inferred from Electronic Annotation more info
defense response to bacterium	ISO Inferred from Sequence Orthology more info
elevation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
immune response	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
lymph node development	IDA Inferred from Direct Assay more info	PubMed
lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
lymphocyte chemotaxis across high endothelial venule	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
positive regulation of integrin activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of receptor activity	ISO Inferred from Sequence Orthology more info
signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: C-X-C motif chemokine 13

Names: C-X-C motif chemokine 13; CXC chemokine BLC; B lymphocyte chemoattractant; small-inducible cytokine B13; small inducible cytokine subfamily B (Cys-X-Cys), member 13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018866.2 → NP_061354.1 C-X-C motif chemokine 13 precursor

Status: PROVISIONAL

Source sequence(s)

AC146611

Consensus CDS

CCDS19447.1

UniProtKB/Swiss-Prot

O55038

UniProtKB/TrEMBL

Q3U1E8

Related

ENSMUSP00000023840, ENSMUST00000023840

Conserved Domains (1) summary

cd00273
Location:29 – 92
Blast Score: 185

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

95956939..95961068

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

93306539..93310668

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01047018.1 (6191..10320)	None
genomic	AC146611.2 (76421..80551)	None
genomic	CH466529.2	EDL20365.1	mixed
mRNA	AF030636.1	AAC34603.1
mRNA	AF044196.1	AAC14401.1	C57BL/6J
mRNA	AK156025.1	BAE33550.1	NOD
mRNA	AK160241.1	None	C57BL/6J
mRNA	AV229497.2	None	C57BL/6J
mRNA	BB612247.1	None	C57BL/6J
mRNA	BC012965.1	AAH12965.1	FVB/N