alpk2 alpha-kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: alpk2provided by ZNC
Official Full Name: alpha-kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1868
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-1868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb83b04; wu:fb83b04; si:ch211-233a1.1
Summary: Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Acts upstream of or within epicardium morphogenesis; heart contraction; and heart development. Predicted to be located in basolateral plasma membrane. Is expressed in adaxial cell; primitive heart tube; and somite. Orthologous to human ALPK2 (alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (10861711..10879143)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (10770943..10785951)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epicardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-protein kinase 2

Names: heart alpha-protein kinase

XP_017208526.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423781.1 → NP_001410710.1 alpha-protein kinase 2

Status: VALIDATED

Source sequence(s)

BX248399, CR925730

UniProtKB/Swiss-Prot

F1QU13

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

10861711..10879143

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017353037.2 → XP_017208526.1 alpha-protein kinase 2

Conserved Domains (2) summary

smart00410
Location:1593 → 1666

IG_like; Immunoglobulin like

cl28917
Location:1691 → 1926

Alpha_kinase; Alpha kinase family