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rc3h2 ring finger and CCCH-type domains 2 [ Danio rerio (zebrafish) ]

Gene ID: 559834, updated on 27-Mar-2024

Summary

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Official Symbol
rc3h2provided by ZNC
Official Full Name
ring finger and CCCH-type domains 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-694
See related
Ensembl:ENSDARG00000063050 AllianceGenome:ZFIN:ZDB-GENE-060503-694
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-243g18.1
Summary
Predicted to enable RNA binding activity and ubiquitin protein ligase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within posttranscriptional regulation of gene expression and protein ubiquitination. Predicted to be active in cytoplasmic stress granule. Orthologous to human RC3H2 (ring finger and CCCH-type domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 10
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (9595581..9648758)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (9762037..9815609)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A8 Neighboring gene si:ch211-243g18.2 Neighboring gene RAB GTPase activating protein 1 Neighboring gene probable G-protein coupled receptor 21 Neighboring gene spermatid perinuclear RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA stem-loop binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING finger and CCCH-type zinc finger domain-containing protein 2; roquin-2
Names
ring finger and CCCH-type zinc finger domains 2
XP_017213498.1
XP_688313.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    9595581..9648758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_683221.7 → XP_688313.4  roquin-2

    UniProtKB/TrEMBL
    A0A8N7TD11, F1Q4N1
    Related
    ENSDARP00000086213.4, ENSDART00000091780.5
    Conserved Domains (2) summary
    pfam00642
    Location:411 → 435
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam14634
    Location:14 → 55
    zf-RING_5; zinc-RING finger domain

  2. XM_017358009.2 → XP_017213498.1  roquin-2

    UniProtKB/TrEMBL
    A0A8N7TD11, F1Q4N1
    Conserved Domains (2) summary
    pfam00642
    Location:411 → 435
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam14634
    Location:14 → 55
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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