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MAPK6 mitogen-activated protein kinase 6 [ Homo sapiens (human) ]

Gene ID: 5597, updated on 8-May-2016
Official Symbol
MAPK6provided by HGNC
Official Full Name
mitogen-activated protein kinase 6provided by HGNC
Primary source
HGNC:HGNC:6879
See related
Ensembl:ENSG00000069956 HPRD:04213; MIM:602904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK3; PRKM6; p97MAPK; HsT17250
Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Orthologs
Location:
15q21
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (52004265..52066265)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52296377..52358462)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370818 Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component pseudogene Neighboring gene LEO1 homolog, Paf1/RNA polymerase II complex component Neighboring gene ribosomal protein S13 pseudogene 8 Neighboring gene BCL2 like 10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

Go to the HIV-1, Human Interaction Database

  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal Transduction of S1P Receptor, organism-specific biosystem (from WikiPathways)
    Signal Transduction of S1P Receptor, organism-specific biosystemMetabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686F03189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
mitogen-activated protein kinase 6
Names
ERK-3
MAP kinase 6
MAP kinase isoform p97
MAPK 6
extracellular signal-regulated kinase 3
extracellular signal-regulated kinase, p97
p97-MAPK
protein kinase, mitogen-activated 5
protein kinase, mitogen-activated 6
NP_002739.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002748.3NP_002739.1  mitogen-activated protein kinase 6

    See identical proteins and their annotated locations for NP_002739.1

    Status: REVIEWED

    Source sequence(s)
    AC023906, BC035492, DA109756, L77964
    Consensus CDS
    CCDS10147.1
    UniProtKB/Swiss-Prot
    Q16659
    Related
    ENSP00000261845, OTTHUMP00000162717, ENST00000261845, OTTHUMT00000254841
    Conserved Domains (2) summary
    cd07854
    Location:14355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20316
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    52004265..52066265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254536.3XP_005254593.1  

    See identical proteins and their annotated locations for XP_005254593.1

    UniProtKB/Swiss-Prot
    Q16659
    Conserved Domains (2) summary
    cd07854
    Location:14355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_005254539.3XP_005254596.1  

    See identical proteins and their annotated locations for XP_005254596.1

    UniProtKB/Swiss-Prot
    Q16659
    Conserved Domains (2) summary
    cd07854
    Location:14355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. XM_005254538.2XP_005254595.1  

    See identical proteins and their annotated locations for XP_005254595.1

    UniProtKB/Swiss-Prot
    Q16659
    Conserved Domains (2) summary
    cd07854
    Location:14355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_011521782.1XP_011520084.1  

    See identical proteins and their annotated locations for XP_011520084.1

    UniProtKB/Swiss-Prot
    Q16659
    Conserved Domains (2) summary
    cd07854
    Location:14355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. XM_005254537.2XP_005254594.1  

    See identical proteins and their annotated locations for XP_005254594.1

    UniProtKB/Swiss-Prot
    Q16659
    Conserved Domains (2) summary
    cd07854
    Location:14355
    STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3)
    smart00220
    Location:20316
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    52429454..52476450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)