MAPK4 mitogen-activated protein kinase 4 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: MAPK4provided by HGNC
Official Full Name: mitogen-activated protein kinase 4provided by HGNC
Primary source: HGNC:6878
See related: Ensembl:ENSG00000141639; HPRD:01497; MIM:176949
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ERK3; Erk4; PRKM4; p63MAPK
Summary: Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008]
Annotation information: Annotation category: partial on reference assembly

Help top of page

Genomic context

Location :: 18q21.2

Sequence :: Chromosome: 18; NC_000018.9 (48189458..48258196)

See MAPK4 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identify the Erk3 protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling.
Title: Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity.
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
Title: Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5.
Title: Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.
These findings, together with observations that si-hBVR blocked activation of ERK and Elk1 by IGF1 and prevented formation of ternary complex between MEK/ERK/hBVR, define the critical role of hBVR in ERK signaling and nuclear functions of the kinase.
Title: Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.
Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
Title: A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3.
Insulin-like growth factor type-I receptor-dependent phosphorylation of ERK3 can be induced by picropodophyllin.
Title: Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
These findings further expand distinct roles of cyclin D3 and suggest the potential activity of ERK3 in cell proliferation.
Title: Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3.
Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3.
Title: Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR)	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs
P31152	P30281	CCND3	HPRD	PubMed
P31152	Q13480	GAB1	HPRD	PubMed
P31152	Q9UQC2	GAB2	HPRD	PubMed
P31152	P31152	MAPK4	HPRD	PubMed
P31152	Q8IW41	MAPKAPK5	HPRD	PubMed

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
MAP kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
MAPK cascade	TAS Traceable Author Statement more info	PubMed
cell cycle	IEA Inferred from Electronic Annotation more info
protein phosphorylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: mitogen-activated protein kinase 4

Names: mitogen-activated protein kinase 4; ERK-4; MAPK 4; p63-MAPK; Erk3-related; MAP kinase 4; MAP kinase isoform p63; extracellular signal-regulated kinase 4

NP_002738.2

EC 2.7.11.24

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002747.3 → NP_002738.2 mitogen-activated protein kinase 4

Status: REVIEWED

Source sequence(s)

AI088913, BC040493, BC050299, X59727

Consensus CDS

CCDS42437.1

UniProtKB/TrEMBL

A1A4C4

UniProtKB/Swiss-Prot

P31152

UniProtKB/TrEMBL

Q0VG04

Related

ENSP00000383234, ENST00000400384

Conserved Domains (2) summary

cd07854
Location:14 – 351
Blast Score: 1674

STKc_MAPK4_6; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 and 6

pfam00069
Location:20 – 312
Blast Score: 656

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p5 Primary Assembly

Range

48189458..48258196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

45044138..45112864

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC012433.7 (95241..144803)	None
genomic	AC090395.3 (35913..54703)	None
genomic	AC090638.11 (165749..180428)	None
genomic	CH471096.1	EAW62976.1
		EAW62977.1
mRNA	AI088913.1	None
mRNA	AK293818.1	BAG57223.1
mRNA	AK295058.1	BAG58107.1
mRNA	AK303601.1	BAG64616.1
mRNA	BC040493.1	None
mRNA	BC050299.1	AAH50299.1
mRNA	BC117216.1	AAI17217.1
mRNA	BC143769.1	None
mRNA	X59727.1	CAA42411.1
other-genetic	HQ258629.1	ADR83381.1