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    DMAP1 DNA methyltransferase 1 associated protein 1 [ Homo sapiens ]

    Gene ID: 55929, updated on 11-May-2012
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    Summary

    Official Symbol
    DMAP1provided by HGNC
    Official Full Name
    DNA methyltransferase 1 associated protein 1provided by HGNC
    Primary source
    HGNC:18291
    Locus tag
    RP5-891H21.2
    See related
    Ensembl:ENSG00000178028; HPRD:05465; MIM:605077; Vega:OTTHUMG00000007577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1; FLJ11543; KIAA1425; DKFZp686L09142
    Summary
    This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p34
    Sequence :
    Chromosome: 1; NC_000001.10 (44679125..44686351)
    See DMAP1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 146 pseudogene Neighboring gene metaxin 3 pseudogene Neighboring gene ERI1 exoribonuclease family member 3 Neighboring gene ring finger protein 220

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    2. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307.
    3. Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance. Chen CC, et al. Head Neck, 2011 Aug. PMID 21284050.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Kim J, et al. Cell, 2010 Oct 15. PMID 20946988.

    See all (39) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. positive staining for DNMT1 in clinical cancer specimens was significantly linked to lower rates of response to treatments and shorter survival of patients with pharyngeal cancer.
      Title: Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.
    2. Knocking down DMAP1 caused hypomethylation of the DNA repair products.
      Title: DNA methyltransferase 1-associated protein (DMAP1) is a co-repressor that stimulates DNA methylation globally and locally at sites of double strand break repair.
    3. MMTR is an intrinsic negative cell cycle regulator that modulates the CAK kinase activity via interaction with MAT1.
      Title: Corepressor MMTR/DMAP1 is an intrinsic negative regulator of CAK kinase to regulate cell cycle progression.
    4. RGS6 inhibited the transcriptional repressor activity of DMAP1.
      Title: RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_061973.1 NP_001370.1 DNMT1    BIND  PubMed DNMT1 interacts with DMAP1. 
    NP_061973.1 NP_004287.3 RGS6    BIND  PubMed RGS6S interacts with DMAP1. 
    Q9NPF5 Q9NV56 C20orf20    HPRD  PubMed  
    Q9NPF5 Q9UER7 DAXX    HPRD  PubMed  
    Q9NPF5 P26358 DNMT1    HPRD  PubMed  
    Q9NPF5 Q92769 HDAC2    HPRD  PubMed  
    Q9NPF5 Q9UK53 ING1    HPRD  PubMed  
    Q9NPF5 P49758 RGS6    HPRD  PubMed  
    Q9NPF5 Q15785 TOMM34    HPRD  PubMed  
    Q9NPF5 Q99816 TSG101    HPRD  PubMed  
    Q9NPF5 O94763 URI1    HPRD  PubMed  
    BioGRID:121004 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:116108 BRD8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:120548 C20orf20    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:115349 CHAF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121004 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121004 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:121004 BioGRID:121676 EP400    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:123227 EPC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:117564 EPC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121004 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:121004 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:121004 BioGRID:120041 ING3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:110474 MNAT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:121004 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121004 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121004 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:114987 RGS6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:121004 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:116058 SRCAP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:121004 BioGRID:113102 TSG101    BioGRID  PubMed Two-hybrid 
    BioGRID:121004 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:114264 URI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:121004 BioGRID:112804 VPS72    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:121004 BioGRID:113761 YEATS4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:121004 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the DMAP1 gene: The DMAP1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II repressing transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA methylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H2A acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription factor import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    replication fork IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    DNA methyltransferase 1-associated protein 1
    Names
    DNA methyltransferase 1-associated protein 1
    DNMT1 associated protein 1
    DNMT1-associated protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034023.1 → NP_001029195.1  DNA methyltransferase 1-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL137200, BM827551, BU616029, CA842195
      Consensus CDS
      CCDS509.1
      UniProtKB/Swiss-Prot
      Q9NPF5
      Related
      ENSP00000312697, OTTHUMP00000008846, ENST00000315913, OTTHUMT00000020026
      Conserved Domains (1) summary
      pfam05499
      Location:243 – 404
      Blast Score: 510
      DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)

    2. NM_001034024.1 → NP_001029196.1  DNA methyltransferase 1-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      BC002855, BM827551, BU616029
      Consensus CDS
      CCDS509.1
      UniProtKB/Swiss-Prot
      Q9NPF5
      Related
      ENSP00000354697, OTTHUMP00000008845, ENST00000361745, OTTHUMT00000020025
      Conserved Domains (1) summary
      pfam05499
      Location:243 – 404
      Blast Score: 510
      DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)

    3. NM_019100.4 → NP_061973.1  DNA methyltransferase 1-associated protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      BC008053, BM827551, BU616029, CB123593
      Consensus CDS
      CCDS509.1
      UniProtKB/Swiss-Prot
      Q9NPF5
      Related
      ENSP00000361363, OTTHUMP00000008847, ENST00000372289, OTTHUMT00000020027
      Conserved Domains (1) summary
      pfam05499
      Location:243 – 404
      Blast Score: 510
      DMAP1; DNA methyltransferase 1-associated protein 1 (DMAP1)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      44679125..44686351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      42792967..42800193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL035417.15 CAI23197.1
      CAI23198.1
      CAI23199.1
      CAI23200.1
      CAI23201.1
      CAI23202.1
    genomic CH471059.2 EAX07046.1
      EAX07047.1
      EAX07048.1
      EAX07049.1
      EAX07050.1
      EAX07051.1
    mRNA AB037846.1 BAA92663.1
    mRNA AF265228.1 AAF87079.1
    mRNA AK021605.1 BAB13854.1
    mRNA AK054954.1 None
    mRNA AK092898.1 None
    mRNA AK096252.1 None
    mRNA AK289366.1 BAF82055.1
    mRNA AK293598.1 BAG57063.1
    mRNA AK298793.1 BAG60930.1
    mRNA AK300217.1 BAG61985.1
    mRNA AK300372.1 BAG62108.1
    mRNA AK300442.1 BAG62165.1
    mRNA AL136657.1 CAB66592.1
    mRNA AL137200.1 CAB69910.1
    mRNA BC002855.2 AAH02855.1
    mRNA BC008053.2 AAH08053.1
    mRNA BM827551.1 None
    mRNA BU616029.1 None
    mRNA BX537895.1 CAD97886.1
    mRNA CA842195.1 None
    mRNA CB123593.1 None
    other-genetic AM393614.1 CAL38490.1
    other-genetic DQ893174.2 ABM84100.1
    other-genetic DQ896473.2 ABM87472.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TG36 GenPept UniProtKB/TrEMBL:Q5TG36
    Q5TG37 GenPept UniProtKB/TrEMBL:Q5TG37
    Q5TG38 GenPept UniProtKB/TrEMBL:Q5TG38
    Q5TG40 GenPept UniProtKB/TrEMBL:Q5TG40
    Q9NPF5.1 GenPept UniProtKB/Swiss-Prot:Q9NPF5
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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