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    RNF114 ring finger protein 114 [ Homo sapiens ]

    Gene ID: 55905, updated on 11-May-2012
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    Summary

    Official Symbol
    RNF114provided by HGNC
    Official Full Name
    ring finger protein 114provided by HGNC
    Primary source
    HGNC:13094
    See related
    Ensembl:ENSG00000124226; HPRD:10329; MIM:612451; Vega:OTTHUMG00000032709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF313; PSORS12
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    Genomic context

    Location :
    20q13.13
    Sequence :
    Chromosome: 20; NC_000020.10 (48552914..48570422)
    See RNF114 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) pseudogene Neighboring gene spermatogenesis associated 2 Neighboring gene keratin 18 pseudogene 4 Neighboring gene snail homolog 1 (Drosophila)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis. Bijlmakers MJ, et al. Hum Mol Genet, 2011 Aug 15. PMID 21571784.

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. RNF114 regulates a positive feedback loop that enhances double-stranded RNA induced production of type I interferon.
      Title: Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association analysis identifies three psoriasis susceptibility loci.
    3. ZNF313 is controlled at the transcriptional level, and a common mechanism controlling the basal transcription of ZNF313 gene exists.
      Title: Sp1 plays an important role in regulating the transcription of ZNF313.
    4. ZNF313 is a novel psoriasis susceptibility gene.
      Title: Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association analysis identifies three psoriasis susceptibility loci.

    Psoriasis susceptibility 12

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y508 Q9Y6K8 AK5    HPRD  PubMed  
    BioGRID:120991 BioGRID:117670 AK5    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:111581 MAPK3    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:121365 PARP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120991 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:120991 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:119641 UBE2D4    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:131075 UBE2DNL    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:113172 UBE2E1    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:113173 UBE2E2    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:115740 UBE2E3    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:113176 UBE2H    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:109340 UBE2K    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:120572 UBE2W    BioGRID  PubMed Two-hybrid 
    BioGRID:120991 BioGRID:120580 UEVLD    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    RING finger protein 114
    Names
    RING finger protein 114
    zinc finger protein 228
    zinc finger protein 313
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018683.3 → NP_061153.1  RING finger protein 114

      Status: VALIDATED

      Source sequence(s)
      AF131742, AK091976, BC013695, BM830132
      Consensus CDS
      CCDS33482.1
      UniProtKB/Swiss-Prot
      Q9Y508
      Related
      ENSP00000244061, OTTHUMP00000031257, ENST00000244061, OTTHUMT00000079663
      Conserved Domains (3) summary
      cd00162
      Location:28 – 71
      Blast Score: 104
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam05605
      Location:141 – 177
      Blast Score: 98
      Di19; Drought induced 19 protein (Di19)
      pfam13923
      Location:26 – 69
      Blast Score: 101
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      48552914..48570422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      45301383..45318830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031685.18 CAB46028.1
    genomic CH471077.2 EAW75641.1
      EAW75642.1
      EAW75643.1
      EAW75644.1
    mRNA AF131742.1 None
    mRNA AF265215.1 AAF75763.1
    mRNA AK091976.1 None
    mRNA AK097265.1 None
    mRNA AK297188.1 BAG59677.1
    mRNA AK301731.1 BAG63197.1
    mRNA AK315638.1 BAG38006.1
    mRNA BC013695.1 AAH13695.1
    mRNA BC066919.1 AAH66919.1
    mRNA BM830132.1 None
    mRNA BT006795.1 AAP35441.1
    mRNA BX640603.1 CAE45709.1
    other-genetic HQ447087.1 ADQ31574.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y508.1 GenPept UniProtKB/Swiss-Prot:Q9Y508
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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      Supplemental Content

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      Links

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