PRKCZ protein kinase C, zeta [ Homo sapiens ]

Gene ID: 5590, updated on 19-May-2012

Help top of page

Summary

Official Symbol: PRKCZprovided by HGNC
Official Full Name: protein kinase C, zetaprovided by HGNC
Primary source: HGNC:9412
See related: Ensembl:ENSG00000067606; HPRD:01504; MIM:176982; Vega:OTTHUMG00000001238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKC2; PKC-ZETA
Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 1p36.33-p36.2

Sequence :: Chromosome: 1; NC_000001.10 (1981909..2116834)

See PRKCZ in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HGF induced functional CXCR4 receptor expression in breast cancer cells. The effect of HGF was specifically mediated by PKCzeta activity.
Title: HGF-induced PKCζ activation increases functional CXCR4 expression in human breast cancer cells.
High levels of protein kinase C zeta expression were associated with lymphatic metastasis in squamous cervical cancer.
Title: Over-expression of protein kinase C isoforms (α, δ, θ and ζ) in squamous cervical cancer.
Changes in PKC iota, PKC zeta, and non-muscle MyoIIA expression are likely to participate in pathogenesis of epithelial barrier function in response to local pro-inflammatory signals.
Title: Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.
Inhibition of protein kinase M zeta results in a reduction of synaptic PSD-95 accumulation in developing visual cortex
Title: TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex.
Results indicate that phosphorylation of human DNMT1 by protein kinase C is isoform-specific and provides the first evidence of cooperation between PKCzeta and DNMT1 in the control of the DNA methylation patterns of the genome.
Title: PKC isoforms interact with and phosphorylate DNMT1.
human platelets express PKCzeta, and it may be constitutively phosphorylated at the activation loop threonine 410 and the turn motif threonine 560 under basal resting conditions, which are differentially dephosphorylated by outside-in signaling
Title: Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in platelets.
The PKCzeta activation by d-flow induces endothelial cell (EC) apoptosis by regulating p53.
Title: PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
that upon DAMGO treatment, MOR activates PKCzeta through a PDK1-dependent signaling pathway to induce CCR5 phosphorylation and desensitization.
Title: Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.
The prognostic impact of TGF-beta1, NF-kappaB p105, PKC-zeta, Par-6alpha, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas, was investigated.
Title: The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas.
low levels of expression are associated with poorly differentiated tumours and a poor outcome in breast cancer patients
Title: PKCzeta regulates cell polarisation and proliferation restriction during mammary acinus formation.

Submit: New GeneRIF Correction See all (118)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax	PubMed
	env	Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways	PubMed
	env	HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels	PubMed
	env	Downmodulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection	PubMed
	env	A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C	PubMed
	env	IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate	PubMed
	env	A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC	PubMed
Tat	tat	Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth	PubMed
	tat	Protein kinase C phosphorylates HIV-1 Tat on serine residue 46	PubMed
	tat	HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1	PubMed
retropepsin	gag-pol	Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease	PubMed
reverse transcriptase	gag-pol	HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_002735.3		HNRNPA1	BIND	PubMed	PKC-zeta phosphorylates and interacts with hnRNPA1. This interaction was modeled on a demonstrated interaction between PKC-zeta and hnRNPA1, both from unspecified species.
NP_002735.3	NP_002376.1	MBP	BIND	PubMed	PKC-zeta phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-zeta and MBP, both from unspecified species.
NP_002735.3	NP_002574.1	PAWR	BIND	PubMed	Par-4 interacts with PKC-zeta. This interaction was modelled on a demonstrated interaction between human Par-4 and rat PKC-zeta.
NP_002735.3	NP_002604.1	PDPK1	BIND	PubMed	PRKCZ (PKCZ) interacts with PDPK1 (PDK1). This interaction was modelled on a demonstrated interaction between human PRKCZ and rat PDPK1.
NP_002735.3		PDPK1	BIND	PubMed	An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCZ (PKC-zeta). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCZ from an unspecified species.
NP_002735.3	AAP88860.1	PRKCSH	BIND	PubMed	PRKCZ (PKCZ) interacts with PRKCSH (80K-H).
NP_002735.3	NP_002735.3	PRKCZ	BIND	PubMed	PKC-zeta autophosphorylates.
NP_002735.3	NP_003891.1	SQSTM1	BIND	PubMed	zetaPKC interacts with p62. This interaction was modelled on a demonstrated interaction between rat zetaPKC and human p62.
NP_002735.3			BIND	PubMed	T-beta-R1/T-beta-R2/Par6 complex interacts with PKC zeta. This interaction was modeled on a demonstrated interaction between T-beta-R1/T-beta-R2/Par6 and PKC zeta both from unspecified species.
Q05513	O75689	ADAP1	HPRD	PubMed
Q05513	O95622	ADCY5	HPRD	PubMed
Q05513	Actin filament associated protein	AFAP1	HPRD	PubMed
Q05513	P31749	AKT1	HPRD	PubMed
Q05513	Q9Y243	AKT3	HPRD	PubMed
Q05513	Q06187	BTK	HPRD	PubMed
Q05513	Q07021	C1QBP	HPRD	PubMed
Q05513	P42574	CASP3	HPRD	PubMed
Q05513	P55212	CASP6	HPRD	PubMed
Q05513	P55210	CASP7	HPRD	PubMed
Q05513	Q14790	CASP8	HPRD	PubMed
Q05513	P55211	CASP9	HPRD	PubMed
Q05513	P60953	CDC42	HPRD	PubMed
Q05513	P28329	CHAT	HPRD	PubMed
Q05513	P67870	CSNK2B	HPRD	PubMed
Q05513	O43293	DAPK3	HPRD	PubMed
Q05513	Q13158	FADD	HPRD	PubMed
Q05513	Q99689	FEZ1	HPRD	PubMed
Q05513	Q9UHY8	FEZ2	HPRD	PubMed
Q05513	Q8WU20	FRS2	HPRD	PubMed
Q05513	P06241	FYN	HPRD	PubMed
Q05513	O76003	GLRX3	HPRD	PubMed
Q05513	Q14449	GRB14	HPRD	PubMed
Q05513	P41594	GRM5	HPRD	PubMed
Q05513	P49840	GSK3A	HPRD	PubMed
Q05513	P49841	GSK3B	HPRD	PubMed
Q05513	Q5JVS0	HABP4	HPRD	PubMed
Q05513	P01112	HRAS	HPRD	PubMed
Q05513	O14920	IKBKB	HPRD	PubMed
Q05513	P24394	IL4R	HPRD	PubMed
Q05513	P51617	IRAK1	HPRD	PubMed
Q05513	P35568	IRS1	HPRD	PubMed
Q05513	Insulin receptor substrate 4	IRS4	HPRD	PubMed
Q05513	P23458	JAK1	HPRD	PubMed
Q05513	P13645	KRT10	HPRD	PubMed
Q05513	Q02750	MAP2K1	HPRD	PubMed
Q05513	Q13163	MAP2K5	HPRD	PubMed
Q05513	P28482	MAPK1	HPRD	PubMed
Q05513	P27361	MAPK3	HPRD	PubMed
Q05513	P02686	MBP	HPRD	PubMed
Q05513	P14598	NCF1	HPRD	PubMed
Q05513	P19338	NCL	HPRD	PubMed
Q05513	Q13469	NFATC2	HPRD	PubMed
Q05513	P49757	NUMB	HPRD	PubMed
Q05513	Q9NPB6	PARD6A	HPRD	PubMed
Q05513	Q9BYG5	PARD6B	HPRD	PubMed
Q05513	Q9BYG4	PARD6G	HPRD	PubMed
Q05513	Q96IZ0	PAWR	HPRD	PubMed
Q05513	Q9NR12	PDLIM7	HPRD	PubMed
Q05513	O15530	PDPK1	HPRD	PubMed
Q05513	P30086	PEBP1	HPRD	PubMed
Q05513	Q96A00	PPP1R14A	HPRD	PubMed
Q05513	Q08209	PPP3CA	HPRD	PubMed
Q05513	P13727	PRG2	HPRD	PubMed
Q05513	P17252	PRKCA	HPRD	PubMed
Q05513	Q05655	PRKCD	HPRD	PubMed
Q05513	Q05513	PRKCZ	HPRD	PubMed
Q05513	P49768	PSEN1	HPRD	PubMed
Q05513	P04049	RAF1	HPRD	PubMed
Q05513	Q04206	RELA	HPRD	PubMed
Q05513	P61586	RHOA	HPRD	PubMed
Q05513	Q9NY26	SLC39A1	HPRD	PubMed
Q05513	Q13501	SQSTM1	HPRD	PubMed
Q05513	P12931	SRC	HPRD	PubMed
Q05513	P42226	STAT6	HPRD	PubMed
Q05513	Q9Y4K3	TRAF6	HPRD	PubMed
Q05513	Q8IX03	WWC1	HPRD	PubMed
Q05513	P31946	YWHAB	HPRD	PubMed
BioGRID:111576	BioGRID:116222	ADAP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:111576	BioGRID:106710	AKT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:115318	AKT3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:111576	BioGRID:107169	C1QBP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111576	BioGRID:124043	CCDC115	BioGRID	PubMed	Two-hybrid
BioGRID:111576	BioGRID:107843	CSNK2B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:107983	DAPK3	BioGRID	PubMed	Reconstituted Complex
BioGRID:111576	BioGRID:116861	DENND5A	BioGRID	PubMed	Two-hybrid
BioGRID:111576	BioGRID:108223	ECT2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:114302	FADD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:114997	FEZ1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:114996	FEZ2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:109145	GRB14	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Two-hybrid
BioGRID:111576	BioGRID:109863	IRAK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:110056	KRT10	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:111593	MAP2K5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111576	BioGRID:110325	MBP	BioGRID	PubMed	Biochemical Activity
BioGRID:111576	BioGRID:110573	MSH2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:109211	MSH6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:110771	NCL	BioGRID	PubMed	Biochemical Activity
BioGRID:111576	BioGRID:110846	NFATC2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:111576	BioGRID:114794	NMT2	BioGRID	PubMed	Two-hybrid
BioGRID:111576	BioGRID:121134	PARD3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:119157	PARD6A	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BioGRID:111576	BioGRID:124145	PARD6B	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BioGRID:111576	BioGRID:124135	PARD6G	BioGRID	PubMed	Affinity Capture-MS; Two-hybrid
BioGRID:111576	BioGRID:111108	PAWR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111576	BioGRID:111196	PDPK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:111576	BioGRID:119624	PIAS4	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:111576	BioGRID:111576	PRKCZ	BioGRID	PubMed	Biochemical Activity
BioGRID:111576	BioGRID:111831	RAF1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111576	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:111576	BioGRID:112112	RPS6KB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:111576	BioGRID:114397	SQSTM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex
BioGRID:111576	BioGRID:112930	TIAM1	BioGRID	PubMed	Biochemical Activity
BioGRID:111576	BioGRID:112954	TLR4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:119902	TLR9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:113041	TRAF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:124780	TRIM41	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111576	BioGRID:116026	UTP14A	BioGRID	PubMed	Two-hybrid
BioGRID:111576	BioGRID:116884	WWC1	BioGRID	PubMed	Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:111576	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:111576	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:113365	YWHAH	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111576	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:111576	BioGRID:113366	YWHAZ	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:111576	BioGRID:121821	ZNF71	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
insulin receptor substrate binding	IC Inferred by Curator more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C activity	IEA Inferred from Electronic Annotation more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
anti-apoptosis	TAS Traceable Author Statement more info	PubMed
blood coagulation	TAS Traceable Author Statement more info
establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
inflammatory response	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
platelet activation	TAS Traceable Author Statement more info
positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 2 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of T-helper 2 cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of excitatory postsynaptic membrane potential	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-10 secretion	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-13 secretion	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-5 secretion	ISS Inferred from Sequence or Structural Similarity more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
apical cortex	IEA Inferred from Electronic Annotation more info
cell cortex	IEA Inferred from Electronic Annotation more info
cell-cell junction	IDA Inferred from Direct Assay more info
cytoplasm	IEA Inferred from Electronic Annotation more info
endosome	IEA Inferred from Electronic Annotation more info
membrane fraction	TAS Traceable Author Statement more info	PubMed
myelin sheath abaxonal region	IEA Inferred from Electronic Annotation more info
nuclear envelope	IEA Inferred from Electronic Annotation more info
nuclear matrix	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
protein complex	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info
tight junction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein kinase C zeta type

Names: protein kinase C zeta type; nPKC-zeta

NP_001028753.1

EC 2.7.11.13

NP_001028754.1

EC 2.7.11.13

NP_001229803.1

EC 2.7.11.13

NP_002735.3

EC 2.7.11.13

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029616.1 RefSeqGene

Range

5001..139926

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001033581.1 → NP_001028753.1 protein kinase C zeta type isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

BC008058, CB152283

Consensus CDS

CCDS41229.1

UniProtKB/Swiss-Prot

Q05513

Related

ENSP00000383712, OTTHUMP00000220759, ENST00000400921, OTTHUMT00000098533

Conserved Domains (2) summary

cd05588
Location:73 – 399
Blast Score: 1768

STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C

smart00220
Location:69 – 335
Blast Score: 737

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_001033582.1 → NP_001028754.1 protein kinase C zeta type isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AL542576, AU134793, BC008058

Consensus CDS

CCDS41229.1

UniProtKB/Swiss-Prot

Q05513

Related

ENSP00000383711, ENST00000400920

Conserved Domains (2) summary

cd05588
Location:73 – 399
Blast Score: 1768

STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C

smart00220
Location:69 – 335
Blast Score: 737

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_001242874.1 → NP_001229803.1 protein kinase C zeta type isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK294782, AL590822, BC008058, DC312466

Consensus CDS

CCDS55563.1

UniProtKB/TrEMBL

B7Z2J7

UniProtKB/TrEMBL

E9PCW2

UniProtKB/Swiss-Prot

Q05513

Related

ENSP00000426412, OTTHUMP00000196802, ENST00000461106, OTTHUMT00000317171

Conserved Domains (3) summary

cd00029
Location:27 – 76
Blast Score: 175

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05588
Location:152 – 478
Blast Score: 1791

STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C

smart00220
Location:148 – 414
Blast Score: 737

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_002744.4 → NP_002735.3 protein kinase C zeta type isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC008058, BC014270

Consensus CDS

CCDS37.1

UniProtKB/Swiss-Prot

Q05513

Related

ENSP00000367830, OTTHUMP00000001368, ENST00000378567, OTTHUMT00000003648

Conserved Domains (4) summary

cd00029
Location:131 – 180
Blast Score: 170

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd06404
Location:16 – 98
Blast Score: 386

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

cd05588
Location:256 – 582
Blast Score: 1797

STKc_aPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C

smart00220
Location:252 – 518
Blast Score: 742

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

1981909..2116834

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

1259190..1392660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL162271.11 (2000..6579)	None
genomic	AL391845.49	CAI15438.1
genomic	AL590822.37 (101..42448)	None
genomic	AL645703.18	CAI21535.1
genomic	CH471183.1	EAW56130.1
		EAW56131.1
mRNA	AB007974.1	None
mRNA	AK097627.1	BAG53497.1
mRNA	AK131526.1	None
mRNA	AK290995.1	BAF83684.1
mRNA	AK294649.1	BAH11833.1
mRNA	AK294782.1	BAH11883.1
mRNA	AK302160.1	BAH13641.1
mRNA	AK310372.1	None
mRNA	AL542576.3	None
mRNA	AU134793.2	None
mRNA	BC008058.2	AAH08058.1
mRNA	BC014270.2	AAH14270.1
mRNA	BT007082.1	AAP35745.1
mRNA	CB152283.1	None
mRNA	DC312466.1	None
mRNA	L14283.1	AAA36488.1
mRNA	Z15108.1	CAA78813.1
other-genetic	DQ892929.2	ABM83855.1
other-genetic	DQ893922.2	ABM84848.1
other-genetic	DQ896178.2	ABM87177.1