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GPRC5C G protein-coupled receptor, class C, group 5, member C [ Homo sapiens (human) ]

Gene ID: 55890, updated on 12-May-2015
Official Symbol
GPRC5Cprovided by HGNC
Official Full Name
G protein-coupled receptor, class C, group 5, member Cprovided by HGNC
Primary source
HGNC:HGNC:13309
See related
HPRD:16178; MIM:605949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAIG3; RAIG-3
Summary
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
See GPRC5C in MapViewer
Location:
17q25
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (74424503..74451658)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72427480..72447797)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene CD300a molecule Neighboring gene CD300 molecule-like family member b

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
G-protein coupled receptor family C group 5 member C
Names
G-protein coupled receptor family C group 5 member C
G protein-coupled receptor, family C, group 5, member C
orphan G-protein coupled receptor
retinoic acid responsive gene protein
retinoic acid-induced gene 3 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018653.3NP_061123.3  G-protein coupled receptor family C group 5 member C isoform b precursor

    See identical proteins and their annotated locations for NP_061123.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a unique N-terminus compared to isoform a.
    Source sequence(s)
    AF207989, AJ276102, BC004925
    Consensus CDS
    CCDS42378.1
    UniProtKB/TrEMBL
    A0A024R8N9
    UniProtKB/TrEMBL
    Q9BSP0
    UniProtKB/Swiss-Prot
    Q9NQ84
    Conserved Domains (1) summary
    pfam00003
    Location:72312
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. NM_022036.2NP_071319.2  G-protein coupled receptor family C group 5 member C isoform a

    See identical proteins and their annotated locations for NP_071319.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF207989, AK075397, BC004925
    Consensus CDS
    CCDS11699.1
    UniProtKB/TrEMBL
    A0A0C4DFY5
    UniProtKB/TrEMBL
    Q9BSP0
    UniProtKB/Swiss-Prot
    Q9NQ84
    Conserved Domains (1) summary
    pfam00003
    Location:105345
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    74424503..74451658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525022.1XP_011523324.1  

    Conserved Domains (1) summary
    pfam00003
    Location:209449
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. XM_011525023.1XP_011523325.1  

    Conserved Domains (1) summary
    pfam00003
    Location:209449
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  3. XM_011525024.1XP_011523326.1  

  4. XM_005257514.1XP_005257571.1  

    Conserved Domains (1) summary
    pfam00003
    Location:105345
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  5. XM_005257512.1XP_005257569.1  

    Conserved Domains (1) summary
    pfam00003
    Location:160400
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    72492209..72508106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)