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    GPRC5C G protein-coupled receptor, family C, group 5, member C [ Homo sapiens (human) ]

    Gene ID: 55890, updated on 5-May-2013
    Official Symbol
    GPRC5Cprovided by HGNC
    Official Full Name
    G protein-coupled receptor, family C, group 5, member Cprovided by HGNC
    Primary source
    HGNC:13309
    Locus tag
    PSEC0087
    See related
    HPRD:16178; MIM:605949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAIG3; RAIG-3
    Summary
    The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    17q25
    Sequence :
    Chromosome: 17; NC_000017.10 (72427667..72443568)
    See GPRC5C in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene CD300a molecule Neighboring gene CD300 molecule-like family member b

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NQ84 O95870 ABHD16A    HPRD  PubMed  
    BioGRID:120980 BioGRID:113650 ABHD16A    BioGRID  PubMed Two-hybrid 
    BioGRID:120980 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC131820

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    G-protein coupled receptor family C group 5 member C
    Names
    G-protein coupled receptor family C group 5 member C
    orphan G-protein coupled receptor
    retinoic acid-induced gene 3 protein
    retinoic acid responsive gene protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018653.3 → NP_061123.3  G-protein coupled receptor family C group 5 member C isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a unique N-terminus compared to isoform a.
      Source sequence(s)
      AF207989, AJ276102, BC004925
      Consensus CDS
      CCDS42378.1
      UniProtKB/TrEMBL
      Q9BSP0
      UniProtKB/Swiss-Prot
      Q9NQ84
      Conserved Domains (1) summary
      pfam00003
      Location:72 – 312
      Blast Score: 295
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    2. NM_022036.2 → NP_071319.2  G-protein coupled receptor family C group 5 member C isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF207989, AK075397, BC004925
      Consensus CDS
      CCDS11699.1
      UniProtKB/TrEMBL
      Q9BSP0
      UniProtKB/Swiss-Prot
      Q9NQ84
      Conserved Domains (1) summary
      pfam00003
      Location:105 – 345
      Blast Score: 300
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      72427667..72443568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      67836934..67852782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      73511414..73527317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01028838.1 (86673..100647) None
    genomic ABBA01028839.1 None
    genomic AC079325.10 (148734..164635) None
    genomic AMYH01008623.1 (672990..688893) None
    genomic CH471099.1 EAW89160.1
      EAW89161.1
      EAW89162.1
      EAW89163.1
      EAW89164.1
    genomic CS051199.1 CAI72095.1
    mRNA AB451470.1 BAG70284.1
    mRNA AF207989.1 AAF72870.1
    mRNA AJ276102.1 CAC00633.1
    mRNA AK000249.1 BAA91030.1
    mRNA AK075397.1 BAC11595.1
    mRNA AK126429.1 None
    mRNA AK131210.1 BAG54752.1
    mRNA AK222909.1 None
    mRNA BC004925.1 AAH04925.1
    mRNA BC016860.1 AAH16860.2
    mRNA BC069202.1 None
    mRNA BC110848.1 AAI10849.1
    mRNA BC125080.1 AAI25081.1
    mRNA BC125081.1 AAI25082.1
    mRNA BT007435.1 AAP36103.1
    other-genetic DQ891631.2 ABM82557.1
    other-genetic DQ894821.2 ABM85747.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQ84.2 GenPept UniProtKB/Swiss-Prot:Q9NQ84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

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      • Order cDNA clone
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      • BioSystems
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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
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        Link to related Nucleotide entry
      • OMIM
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        Related Probe entry
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
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        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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