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GPRC5C G protein-coupled receptor, class C, group 5, member C [ Homo sapiens (human) ]

Gene ID: 55890, updated on 12-Apr-2014
Official Symbol
GPRC5Cprovided by HGNC
Official Full Name
G protein-coupled receptor, class C, group 5, member Cprovided by HGNC
Primary source
HGNC:13309
Locus tag
PSEC0087
See related
HPRD:16178; MIM:605949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAIG3; RAIG-3
Summary
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Location :
17q25
Sequence :
Chromosome: 17; NC_000017.11 (74431341..74451658)
See GPRC5C in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene CD300a molecule Neighboring gene CD300 molecule-like family member b

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
 
Preferred Names
G-protein coupled receptor family C group 5 member C
Names
G-protein coupled receptor family C group 5 member C
orphan G-protein coupled receptor
retinoic acid-induced gene 3 protein
retinoic acid responsive gene protein
G protein-coupled receptor, family C, group 5, member C

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018653.3NP_061123.3  G-protein coupled receptor family C group 5 member C isoform b precursor

    See proteins identical to NP_061123.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a unique N-terminus compared to isoform a.
    Source sequence(s)
    AF207989, AJ276102, BC004925
    Consensus CDS
    CCDS42378.1
    UniProtKB/TrEMBL
    Q9BSP0
    UniProtKB/Swiss-Prot
    Q9NQ84
    Conserved Domains (1) summary
    pfam00003
    Location:72312
    Blast Score: 299
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. NM_022036.2NP_071319.2  G-protein coupled receptor family C group 5 member C isoform a

    See proteins identical to NP_071319.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF207989, AK075397, BC004925
    Consensus CDS
    CCDS11699.1
    UniProtKB/TrEMBL
    Q9BSP0
    UniProtKB/Swiss-Prot
    Q9NQ84
    Conserved Domains (1) summary
    pfam00003
    Location:105345
    Blast Score: 311
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11

    Range
    74431341..74451658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257514.1XP_005257571.1  

    Conserved Domains (1) summary
    pfam00003
    Location:105345
    Blast Score: 313
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. XM_005257512.1XP_005257569.1  

    Conserved Domains (1) summary
    pfam00003
    Location:160400
    Blast Score: 318
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  3. XM_005257513.1XP_005257570.1  

    Conserved Domains (1) summary
    pfam00003
    Location:160400
    Blast Score: 319
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    67836934..67852782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    72492209..72508106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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