PRKD1 protein kinase D1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: PRKD1provided by HGNC
Official Full Name: protein kinase D1provided by HGNC
Primary source: HGNC:9407
See related: Ensembl:ENSG00000184304; HPRD:05668; MIM:605435; Vega:OTTHUMG00000140203
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKD; PKCM; PRKCM; PKC-MU
Summary: PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]

Help top of page

Genomic context

Location :: 14q11

Sequence :: Chromosome: 14; NC_000014.8 (30045685..30396899, complement)

See PRKD1 in Epigenomics, MapViewer

Chromosome 14 - NC_000014.8 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

it is increasingly apparent that PKD1 is a key player in the regulation of cardiac hypertrophy, most likely through its effect on the transcriptional regulation of fetal gene programming via the phosphorylation of HDAC5. [Review]
Title: Protein kinase D in the hypertrophy pathway.
downregulation of PKD1 expression may determine the behavior of gastric tumor cells, which promotes invasive phenotype and could result in general poor prognosis.
Title: Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system.
agonist-dependent increases in diacylglycerol accumulation lead to the activation of protein kinase C and PKC-dependent phosphorylation of PKD1 at two conserved serine residues in the activation loop; this modification increases PKD1 catalytic activity
Title: Regulation of protein kinase D1 activity.
PAR(1) and PAR(2) are involved in WM9 cell proliferation and secretion of IL-8 by activation of PKD1.
Title: Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1.
serine 1884 is essential for the regulation of hCaV1.2 by PKD
Title: Protein kinase D regulates the human cardiac L-type voltage-gated calcium channel through serine 1884.
protein kinase D activity is essential for exercise-induced MEF2-dependent skeletal muscle remodelling in vivo
Title: Protein kinase D controls voluntary-running-induced skeletal muscle remodelling.
PolyI:C-dependent barrier disruption is mediated by disassembly of epithelial apical junctions, which is dependent on PKD signaling
Title: Polyinosinic:polycytidylic acid induces protein kinase D-dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells.
this review summarizes the structural and functional aspects of PKD1 and highlight the pathobiological roles of this kinase in cancer.[review]
Title: Emerging roles of protein kinase D1 in cancer.
PKD can also regulate LIMK through direct phosphorylation and activation of its upstream kinase p21-activated kinase 4 (PAK4).
Title: Protein kinase D regulates cofilin activity through p21-activated kinase 4.
these data suggest a novel, signal-dependent mechanism for controlling PKD function in cardiac myocytes.
Title: A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy.

Submit: New GeneRIF Correction See all (74)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth	PubMed
	tat	Protein kinase C phosphorylates HIV-1 Tat on serine residue 46	PubMed
	tat	HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_002733.1	NP_006729.4	AKAP13	BIND	PubMed	AKAP-Lbc interacts with PKD.
NP_002733.1	NP_006089.1	GNB2L1	BIND	PubMed	PKC-mu interacts with RACK1.
NP_002733.1	NP_000866.1	IGF1R	BIND	PubMed	PKC-mu interacts with IGF-IR.
NP_002733.1	NP_005391.1	PRKCE	BIND	PubMed	PRKCE (PKC-epsilon) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCE from an unspecified species and human PRKD1.
NP_002733.1	NP_006246.2	PRKCH	BIND	PubMed	PRKCH (PKC-eta) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCH from an unspecified species and human PRKD1.
NP_002733.1	NP_002733.1	PRKD1	BIND	PubMed	PRKD1 (PKC-mu) autophosphorylates.
NP_002733.1	NP_006304.1	USP15	BIND	PubMed	PKD phosphorylates USP15.
Q15139	P00519	ABL1	HPRD	PubMed
Q15139	O75689	ADAP1	HPRD	PubMed
Q15139	Q06187	BTK	HPRD	PubMed
Q15139	Q07021	C1QBP	HPRD	PubMed
Q15139	P00533	EGFR	HPRD	PubMed
Q15139	Q99814	EPAS1	HPRD	PubMed
Q15139	P63244	GNB2L1	HPRD	PubMed
Q15139	Q9UQL6	HDAC5	HPRD	PubMed
Q15139	Q8WUI4	HDAC7	HPRD	PubMed
Q15139	P08069	IGF1R	HPRD	PubMed
Q15139	P05412	JUN	HPRD	PubMed
Q15139	KIDINS220	KIDINS220	HPRD	PubMed
Q15139	P45983	MAPK8	HPRD	PubMed
Q15139	P45984	MAPK9	HPRD	PubMed
Q15139	P02795	MT2A	HPRD	PubMed
Q15139	P19174	PLCG1	HPRD	PubMed
Q15139	P16885	PLCG2	HPRD	PubMed
Q15139	Q96A00	PPP1R14A	HPRD	PubMed
Q15139	Q02156	PRKCE	HPRD	PubMed
Q15139	P24723	PRKCH	HPRD	PubMed
Q15139	Q15139	PRKD1	HPRD	PubMed
Q15139	P12931	SRC	HPRD	PubMed
Q15139	P43405	SYK	HPRD	PubMed
Q15139	P27348	YWHAQ	HPRD	PubMed
BioGRID:111573	BioGRID:116222	ADAP1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:111573	BioGRID:107160	BTK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111573	BioGRID:107169	C1QBP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:111573	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111573	BioGRID:119613	HDAC7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111573	BioGRID:109547	HSPB1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:111573	BioGRID:109928	JUN	BioGRID	PubMed	Biochemical Activity
BioGRID:111573	BioGRID:111585	MAPK8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111573	BioGRID:111587	MAPK9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111573	BioGRID:110608	MT2A	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:111573	BioGRID:204968	Mapk13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111573	BioGRID:111351	PLCG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111573	BioGRID:111352	PLCG2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111573	BioGRID:112717	SYK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111573	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111573	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111573	BioGRID:113366	YWHAZ	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
Golgi vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
cellular response to vascular endothelial growth factor stimulus	IGI Inferred from Genetic Interaction more info
cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
endothelial cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
integrin-mediated signaling pathway	TAS Traceable Author Statement more info
intracellular protein kinase cascade	IGI Inferred from Genetic Interaction more info
intracellular protein kinase cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell death	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endocytosis	TAS Traceable Author Statement more info
nervous system development	IEA Inferred from Electronic Annotation more info
peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of CREB transcription factor activity	IGI Inferred from Genetic Interaction more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info
positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of blood vessel endothelial cell migration	IGI Inferred from Genetic Interaction more info
positive regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info
positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	TAS Traceable Author Statement more info
regulation of integrin-mediated signaling pathway	TAS Traceable Author Statement more info
regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
signal transduction	TAS Traceable Author Statement more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info
sphingolipid biosynthetic process	TAS Traceable Author Statement more info
sphingolipid metabolic process	TAS Traceable Author Statement more info
vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
cell cortex	IEA Inferred from Electronic Annotation more info
cell-cell junction	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	ISS Inferred from Sequence or Structural Similarity more info
cytosol	TAS Traceable Author Statement more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: serine/threonine-protein kinase D1

Names: serine/threonine-protein kinase D1; nPKC-D1; nPKC-mu; protein kinase D; protein kinase C, mu; protein kinase C mu type

NP_002733.2

EC 2.7.11.13

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002742.2 → NP_002733.2 serine/threonine-protein kinase D1

Status: VALIDATED

Source sequence(s)

BX645735, CN412379, X75756

Consensus CDS

CCDS9637.1

UniProtKB/Swiss-Prot

Q15139

Related

ENSP00000333568, OTTHUMP00000178785, ENST00000331968, OTTHUMT00000276611

Conserved Domains (4) summary

cd00029
Location:271 – 320
Blast Score: 180

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00180
Location:589 – 837
Blast Score: 524

PKc; Catalytic domain of Protein Kinases

smart00220
Location:587 – 839
Blast Score: 741

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl00273
Location:424 – 539
Blast Score: 310

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000014.8 Reference GRCh37.p5 Primary Assembly

Range

30045685..30396899, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000146.1 Alternate HuRef

Range

10161470..10512671, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL135858.3	None
genomic	AL355053.4 (27268..124076)	None
genomic	AL356756.4 (659..164089)	None
genomic	AL445884.4 (33299..47978)	None
genomic	CH471078.2	EAW65970.1
		EAW65971.1
genomic	DQ485452.1	ABE96833.1
mRNA	AK314170.1	BAG36853.1
mRNA	BX645735.1	None
mRNA	CN412379.1	None
mRNA	X75756.1	CAA53384.1
other-genetic	BC160015.1	AAI60015.1